2014
Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial
Dysken MW, Sano M, Asthana S, Vertrees JE, Pallaki M, Llorente M, Love S, Schellenberg GD, McCarten JR, Malphurs J, Prieto S, Chen P, Loreck DJ, Trapp G, Bakshi RS, Mintzer JE, Heidebrink JL, Vidal-Cardona A, Arroyo LM, Cruz AR, Zachariah S, Kowall NW, Chopra MP, Craft S, Thielke S, Turvey CL, Woodman C, Monnell KA, Gordon K, Tomaska J, Segal Y, Peduzzi PN, Guarino PD. Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial. JAMA 2014, 311: 33-44. PMID: 24381967, PMCID: PMC4109898, DOI: 10.1001/jama.2013.282834.Peer-Reviewed Original ResearchConceptsAlpha-tocopherol groupModerate Alzheimer's diseaseIU/dAlzheimer's diseaseFunctional declineTocopherol groupAlpha-tocopherolVitamin EAlzheimer's Disease Cooperative Study/ActivitiesVeterans Affairs Medical CenterInventory scoresSlow functional declineSerious adverse eventsSevere Alzheimer's diseaseMemantine groupCause mortalityPlacebo groupSecondary outcomesAdverse eventsRandomized trialsClinical progressionCombination groupCaregiver burdenClinical trialsSlow progression
2010
Robot-Assisted Therapy for Long-Term Upper-Limb Impairment after Stroke
Lo AC, Guarino PD, Richards LG, Haselkorn JK, Wittenberg GF, Federman DG, Ringer RJ, Wagner TH, Krebs HI, Volpe BT, Bever CT, Bravata DM, Duncan PW, Corn BH, Maffucci AD, Nadeau SE, Conroy SS, Powell JM, Huang GD, Peduzzi P. Robot-Assisted Therapy for Long-Term Upper-Limb Impairment after Stroke. New England Journal Of Medicine 2010, 362: 1772-1783. PMID: 20400552, PMCID: PMC5592692, DOI: 10.1056/nejmoa0911341.Peer-Reviewed Original ResearchConceptsWolf Motor Function TestFugl-Meyer scoreUsual careMotor Function TestRobot-assisted therapyStroke Impact ScaleIntensive therapySecondary analysisFunction testsComparison therapyMotor functionImpact ScaleSerious adverse eventsFugl-Meyer AssessmentUpper limb deficitsLong-term deficitsSensorimotor recoveryAdverse eventsSecondary outcomesPrimary outcomeRehabilitative therapyPatientsLimb impairmentTherapyStroke