Induction of p53 in mouse cells decreases mutagenesis by UV radiation
Yuan J, Yeasky T, Havre P, Glazer P. Induction of p53 in mouse cells decreases mutagenesis by UV radiation. Carcinogenesis 1995, 16: 2295-2300. PMID: 7586125, DOI: 10.1093/carcin/16.10.2295.Peer-Reviewed Original ResearchConceptsInduction of p53Cell cycle blockCell linesCycle blockRole of p53Cell cycle analysisInvolvement of p53Lambda phage shuttle vectorWestern blotChromosomal damageClonogenic survivalNucleotide excision repairUV-induced mutationsCellular DNA damageP53 alleleRecent evidenceP53Recoverable lambda phage shuttle vectorFibroblast cell lineMutation reporter geneUV-induced lesionsG1 phaseP53 activityMouse fibroblast cell lineReporter genep53 inactivation by HPV16 E6 results in increased mutagenesis in human cells.
Havre P, Yuan J, Hedrick L, Cho K, Glazer P. p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells. Cancer Research 1995, 55: 4420-4. PMID: 7671255.Peer-Reviewed Original ResearchConceptsHigh-risk E6P53 inactivationHPV16 E6Low-risk E6Human papillomavirus proteinsG1 arrestCell linesHPV16 E6 geneHPV11 E6Carcinoma cell linesColon carcinoma cell linePapillomavirus proteinsLow dosesHPV16 E7E6 geneClonal cell linesE7 bindsNormal p53RKO cellsTumor suppressor protein p53P53 degradationSuppressor protein p53P53E6Protein p53