ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response
Peretz S, Jensen R, Baserga R, Glazer P. ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 1676-1681. PMID: 11172010, PMCID: PMC29316, DOI: 10.1073/pnas.98.4.1676.Peer-Reviewed Original ResearchConceptsWild-type cellsIGF-IR promoter activityAT cellsAtaxia telangiectasiaPromoter activityLevel of transcriptionHeterologous viral promotersDominant negative fragmentTyrosine kinase activityCell surface receptorsATM cDNAIGF-IR expressionIGF-IRInhibition of apoptosisATM functionAT syndromeKinase activityViral promotersCDNA resultsCell transformationInsulin-like growthATM geneSurface receptorsGrowth abnormalitiesExtreme radiosensitivity