A novel human CD1d knock-in mouse model demonstrates potent anti-tumor potential of human CD1d-restricted iNKT cells (P5001)
Yuan W, Wen X, Rao P, Cresswell P, Porcelli S, Kim S, Carreño L, Lawrenczyk A. A novel human CD1d knock-in mouse model demonstrates potent anti-tumor potential of human CD1d-restricted iNKT cells (P5001). The Journal Of Immunology 2013, 190: 110.1-110.1. DOI: 10.4049/jimmunol.190.supp.110.1.Peer-Reviewed Original ResearchINKT cellsHuman iNKT cellsAnti-tumor therapyMouse modelHuman iNKT cell responsesPotent anti-tumor functionsHuman CD1dPowerful anti-tumor effectCD1d antigen presentationFunctional iNKT cellsINKT cell responsesInvariant NKT cellsNKT cell developmentExpression of CD4Conventional mouse modelsAntigen presentation pathwayAnti-tumor functionAnti-tumor effectsHuman clinical trialsAnti-tumor potentialNKT cellsClinical trialsAntigen presentationChallenge modelPreclinical assessment