Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding
Roche P, Cresswell P. Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding. Nature 1990, 345: 615-618. PMID: 2190094, DOI: 10.1038/345615a0.Peer-Reviewed Original ResearchConceptsClass II moleculesImmunogenic peptidesMHC moleculesClass II major histocompatibility complex moleculesClass II MHC moleculesMajor histocompatibility complex moleculesClass I MHC moleculesHLA-DR moleculesII MHC moleculesHistocompatibility complex moleculesI MHC moleculesClass I moleculesIntracellular class II moleculesCell surface expressionT lymphocytesPresent immunogenic peptidesClass IIProtein antigensClass IInvariant chain associationI moleculesCell surface glycoproteinSurface expressionInvariant chainFunctional dichotomy