Sodium-hydrogen exchange isoform expression in blood cells: implications for studies in diabetes mellitus
Rutherford P, Pizzonia J, Abu-Alfa A, Biemesderfer D, Reilly R, Aronson P. Sodium-hydrogen exchange isoform expression in blood cells: implications for studies in diabetes mellitus. Experimental And Clinical Endocrinology & Diabetes 1997, 105: 13-16. PMID: 9288535, DOI: 10.1055/s-0029-1211787.Peer-Reviewed Original ResearchConceptsPeripheral blood cellsPeripheral blood cell preparationsDiabetes mellitusBlood cell preparationsBlood cellsNHE activityPathophysiological roleNa-H exchange activityNHE-1Vascular smooth muscle cell proliferationNHE-3Smooth muscle cell proliferationProgressive renal impairmentNHE isoformsVascular smooth muscleDirect pathophysiological roleCell preparationsMuscle cell proliferationPlatelet membranesNa-H exchangeRenal proximal tubulesNHE isoforms 1Sodium-hydrogen exchangeRenal impairmentNondiabetic controlsExpression of Na(+)-H+ exchanger isoforms NHE1 and NHE3 in kidney and blood cells of rabbit and rat.
Rutherford PA, Pizzonia JH, Biemesderfer D, Abu-Alfa A, Reilly R, Aronson PS. Expression of Na(+)-H+ exchanger isoforms NHE1 and NHE3 in kidney and blood cells of rabbit and rat. Nephron 1997, 5: 490-7. PMID: 9438178.Peer-Reviewed Original ResearchConceptsNa-H exchangeNa-H exchangerBlood cellsRat kidneyNa-Li countertransportNHE1 protein expressionExpression of NHE1Diabetic nephropathyCountertransport activityIsoform-specific antibodiesMonoclonal antibodiesExchanger isoforms NHE1NHE3 expressionRenal brush border membraneProtein expressionBrush border membraneKidneyNHE isoformsRabbitsNHE3Blood cell membranesBrush border membrane fractionRatsIsoforms NHE1Antibodies