2001
Global Analysis of Protein Activities Using Proteome Chips
Zhu H, Bilgin M, Bangham R, Hall D, Casamayor A, Bertone P, Lan N, Jansen R, Bidlingmaier S, Houfek T, Mitchell T, Miller P, Dean R, Gerstein M, Snyder M. Global Analysis of Protein Activities Using Proteome Chips. Science 2001, 293: 2101-2105. PMID: 11474067, DOI: 10.1126/science.1062191.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAmino Acid SequenceCalmodulinCalmodulin-Binding ProteinsCell MembraneCloning, MolecularFungal ProteinsGlucoseLiposomesMembrane ProteinsMolecular Sequence DataOpen Reading FramesPeptide LibraryPhosphatidylcholinesPhosphatidylinositolsPhospholipidsProtein BindingProteomeRecombinant Fusion ProteinsSaccharomyces cerevisiaeSignal TransductionStreptavidinConceptsYeast proteome microarraysDiverse biochemical activitiesOpen reading framePotential binding motifsProtein-drug interactionsEukaryotic proteomesYeast proteomeProteome chipsPosttranslational modificationsReading frameCorresponding proteinNew calmodulinProtein activityBinding motifBiochemical activityProteome microarrayProteinProteomeMicroarrayCalmodulinGlobal analysisMotifPhospholipidsActivity
2000
An integrated web interface for large-scale characterization of sequence data
Cheung K, Kumar A, Snyder M, Miller P. An integrated web interface for large-scale characterization of sequence data. Functional & Integrative Genomics 2000, 1: 70-75. PMID: 11793223, DOI: 10.1007/s101420000004.Peer-Reviewed Original ResearchMeSH KeywordsClinical Laboratory Information SystemsComputational BiologyDatabases, GeneticDatabases, ProteinDNA Transposable ElementsDNA, FungalGene Expression ProfilingGenomeGenome, FungalInternetMutagenesis, InsertionalOpen Reading FramesSaccharomyces cerevisiaeSequence Analysis, DNASequence Homology, Nucleic AcidSoftwareUser-Computer InterfaceConceptsWeb interfaceWeb front endGenomic data processingData filesLarge-scale genome projectsIndependent software programsSet of programsMultiple directoriesData directoryData processingRaw dataTransposon insertion eventsSoftware programFilesFront endDirectoryEfficient protocolLarge amountInterfaceLarge numberGeneral approachUsersSetDownloadNavigation
1999
Large-scale analysis of the yeast genome by transposon tagging and gene disruption
Ross-Macdonald P, Coelho P, Roemer T, Agarwal S, Kumar A, Jansen R, Cheung K, Sheehan A, Symoniatis D, Umansky L, Heidtman M, Nelson F, Iwasaki H, Hager K, Gerstein M, Miller P, Roeder G, Snyder M. Large-scale analysis of the yeast genome by transposon tagging and gene disruption. Nature 1999, 402: 413-418. PMID: 10586881, DOI: 10.1038/46558.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsDNA Transposable ElementsEscherichia coliFungal ProteinsGene Expression ProfilingGenetic TechniquesGenome, FungalMolecular Sequence DataMutagenesisOligonucleotide Array Sequence AnalysisOpen Reading FramesPhenotypePolymerase Chain ReactionSaccharomyces cerevisiaeTransformation, GeneticConceptsGene functionDisruption phenotypesLarge-scale analysisNon-annotated open reading framesGenome-wide analysisOpen reading frameSingle genetic backgroundTransposon taggingYeast genomeYeast mutantsGenomic scaleYeast SaccharomycesDifferent growth conditionsProtein localizationGene disruptionReading frameGene expressionFunctional analysisVegetative growthGenetic backgroundGenesGenomeTransposonGrowth conditionsYeast