2021
A human-blood-derived microRNA facilitates flavivirus infection in fed mosquitoes
Zhu Y, Zhang C, Zhang L, Yang Y, Yu X, Wang J, Liu Q, Wang P, Cheng G. A human-blood-derived microRNA facilitates flavivirus infection in fed mosquitoes. Cell Reports 2021, 37: 110091. PMID: 34910910, DOI: 10.1016/j.celrep.2021.110091.Peer-Reviewed Original ResearchA mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host
Yu X, Shan C, Zhu Y, Ma E, Wang J, Wang P, Shi P, Cheng G. A mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2113015118. PMID: 34620704, PMCID: PMC8545446, DOI: 10.1073/pnas.2113015118.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEvolution, MolecularGenome, ViralHumansMiceMosquito VectorsMutationPhylogenyZika VirusConceptsEvolutionary adaptationZIKV capsid proteinAsian ZIKV lineageZika virusMammalian hostsZIKV mutantsNS2B-NS3 proteaseStructural proteinsPreferred substrateHuman cellsCapsid proteinInfectious viral particlesMutantsMosquito vectorsZIKV disseminationMillions of infectionsZIKV lineagesProteinViral particlesHigh prevalenceImmunodeficient miceMosquito infectionExplosive outbreaksMosquitoesStable substitutions
2016
Glycosphingolipid GM3 is Indispensable for Dengue Virus Genome Replication
Wang K, Wang J, Sun T, Bian G, Pan W, Feng T, Wang P, Li Y, Dai J. Glycosphingolipid GM3 is Indispensable for Dengue Virus Genome Replication. International Journal Of Biological Sciences 2016, 12: 872-883. PMID: 27313500, PMCID: PMC4910605, DOI: 10.7150/ijbs.15641.Peer-Reviewed Original ResearchConceptsDENV infectionDengue virusB16 cellsDENV attachmentSynthetase inhibitorGM95 cellsPrevalent arthropodVirus infectionMouse melanoma B16 cellsMortality rateViral-host interactionsMelanoma B16 cellsMouse brainViral replicationInfectionVirus genome replicationViral diseasesGenome replicationViral genome replicationEndoplasmic reticulumGM3CellsViral replication complexInhibitorsGlycosphingolipids