Mitofusin-2 regulates leukocyte adhesion and β2 integrin activation
Liu W, Hsu AY, Wang Y, Lin T, Sun H, Pachter JS, Groisman A, Imperioli M, Yungher FW, Hu L, Wang P, Deng Q, Fan Z. Mitofusin-2 regulates leukocyte adhesion and β2 integrin activation. Journal Of Leukocyte Biology 2021, 111: 771-791. PMID: 34494308, PMCID: PMC8901796, DOI: 10.1002/jlb.1a0720-471r.Peer-Reviewed Original ResearchConceptsΒ2 integrin activationIntegrin activationMitofusin 2Mfn2 deficiencyConformation-specific monoclonal antibodiesMFN2 knockdownHL60 cellsNeutrophil-like HL60 cellsMolecular detailsActin polymerizationCell spreadingAdhesion defectsReduced expressionInnate immunityKnockdownNew insightsActivationCellsLeukocyte adhesionAdhesionCell rollingCrucial stepMonoclonal antibodiesDifferentiationVascular endothelium