GABA and glycine are protective to mature but toxic to immature rat cortical neurons under hypoxia
Zhao P, Qian H, Xia Y. GABA and glycine are protective to mature but toxic to immature rat cortical neurons under hypoxia. European Journal Of Neuroscience 2005, 22: 289-300. PMID: 16045482, DOI: 10.1111/j.1460-9568.2005.04222.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell CountCell DeathCell DifferentiationCell HypoxiaCells, CulturedCerebral CortexDose-Response Relationship, DrugDrug InteractionsEmbryo, MammalianEnkephalin, Leucine-2-AlanineGamma-Aminobutyric AcidGene Expression Regulation, DevelopmentalGlycineL-Lactate DehydrogenaseNeuronsRatsRats, Sprague-DawleyReceptors, GABA-AReceptors, GlycineReference ValuesTaurineTime FactorsConceptsGamma-aminobutyric acidRat cortical neuronsCortical neuronsInhibitory neurotransmitterHypoxic neuronsImmature neuronsHypoxic cortical neuronsDelta-opioid receptorsMajor inhibitory neurotransmitterHypoxic injuryNeuronal ageMature neuronsNeuronal responsesGlycine receptorsLong-term exposureNeuronsDifferential developmental profilesHypoxiaNeurotransmittersDevelopmental profileReceptorsTaurinePresent studyAgeRecent studies