2006
Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism
Li Y, Wang P, Xu J, Desir GV. Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism. American Journal Of Physiology - Cell Physiology 2006, 290: c345-c351. PMID: 16403947, DOI: 10.1152/ajpcell.00091.2005.Peer-Reviewed Original ResearchConceptsPlasma membraneKv1.3 channel activityAmount of GLUT4GLUT4 protein translocationInsulin sensitivityChannel activityChannel inhibitionAddition of wortmanninGLUT4 traffickingInsulin-dependent pathwayProtein translocationPeripheral insulin sensitivityVoltage-gated potassium channel Kv1.3GLUT4 translocationPotassium channel Kv1.3Gene inactivationInsulin-sensitive tissuesGLUT4 proteinKv1.3 inhibitionGlucose transportPsora-4Channel Kv1.3Adipose tissueBody weightPharmacological inhibition
2005
Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure
Xu J, Li G, Wang P, Velazquez H, Yao X, Li Y, Wu Y, Peixoto A, Crowley S, Desir GV. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. Journal Of Clinical Investigation 2005, 115: 1275-1280. PMID: 15841207, PMCID: PMC1074681, DOI: 10.1172/jci24066.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseBlood pressureRenal diseaseCardiac functionNovel flavin adenine dinucleotide-dependent amine oxidaseFlavin adenine dinucleotide-dependent amine oxidaseSystemic blood pressurePeripheral vascular toneRenalase gene expressionCardiovascular morbiditySoluble monoamine oxidaseVascular toneAvailable therapiesPlasma concentrationsCardiac contractilityEndocrine functionEndocrine organHealthy subjectsHeart rateElectrolyte balanceCompensatory increaseSmall intestineKidneyRenalaseMonoamine oxidase