Novel MicroRNA Candidates and miRNA-mRNA Pairs in Embryonic Stem (ES) Cells
Gu P, Reid J, Gao X, Shaw C, Creighton C, Tran P, Zhou X, Drabek R, Steffen D, Hoang D, Weiss M, Naghavi A, El-daye J, Khan M, Legge G, Wheeler D, Gibbs R, Miller J, Cooney A, Gunaratne P. Novel MicroRNA Candidates and miRNA-mRNA Pairs in Embryonic Stem (ES) Cells. PLOS ONE 2008, 3: e2548. PMID: 18648548, PMCID: PMC2481296, DOI: 10.1371/journal.pone.0002548.Peer-Reviewed Original ResearchConceptsMiRNA-mRNA pairsEmbryonic stem cellsES cellsMiRNA candidatesPost-transcriptional gene regulationTranscriptional gene regulationCore regulatory networkLoss of repressionMiRNA target predictionOpposite expression trendsStem cellsES cell differentiationNovel candidatesNovel miRNAsGene regulationSmall RNAsMiRNA maturationGene networksTranscript sequencesRegulatory networksExpression trendsSilico searchMicroRNA candidatesCell differentiationTarget prediction