2005
Evolutionary Trace-based Peptides Identify a Novel Asymmetric Interaction That Mediates Oligomerization in Nuclear Receptors*
Gu P, Morgan DH, Sattar M, Xu X, Wagner R, Raviscioni M, Lichtarge O, Cooney AJ. Evolutionary Trace-based Peptides Identify a Novel Asymmetric Interaction That Mediates Oligomerization in Nuclear Receptors*. Journal Of Biological Chemistry 2005, 280: 31818-31829. PMID: 15994320, DOI: 10.1074/jbc.m501924200.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Vesicular TransportAmino Acid SequenceCell LineDimerizationDNA-Binding ProteinsEvolution, MolecularGenes, ReporterMolecular Sequence DataNuclear Receptor Subfamily 6, Group A, Member 1PeptidesPoint MutationProtein Structure, SecondaryProtein Structure, TertiaryReceptor Cross-TalkReceptors, Cytoplasmic and NuclearReceptors, Retinoic AcidResponse ElementsConceptsGerm cell nuclear factorEvolutionary trace analysisNuclear receptorsKey functional sitesOrphan nuclear receptorDR0 elementsGCNF bindsComplex formationEssential genesEvolutionary traceMolecular basisOligomerization propertiesHelix 3Heterotypic interactionsTargeted mutationsLarge complexesNovel helixFunctional sitesHelix 11HomodimerNuclear factorDimerizationOligomerizationHelixMutations
2003
GCNF‐dependent repression of BMP‐15 and GDF‐9 mediates gamete regulation of female fertility
Lan Z, Gu P, Xu X, Jackson KJ, DeMayo FJ, O'Malley BW, Cooney AJ. GCNF‐dependent repression of BMP‐15 and GDF‐9 mediates gamete regulation of female fertility. The EMBO Journal 2003, 22: 4070-4081. PMID: 12912906, PMCID: PMC175795, DOI: 10.1093/emboj/cdg405.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 15Bone Morphogenetic ProteinsCHO CellsCricetinaeDNA-Binding ProteinsEgg ProteinsFemaleFertilityGene Expression RegulationGrowth Differentiation Factor 9IntegrasesIntercellular Signaling Peptides and ProteinsMembrane GlycoproteinsMiceMice, KnockoutMice, TransgenicModels, BiologicalNuclear Receptor Subfamily 6, Group A, Member 1OocytesOvaryReceptors, Cell SurfaceReceptors, Cytoplasmic and NuclearRepressor ProteinsTransforming Growth Factor betaTransgenesViral ProteinsZona PellucidaZona Pellucida GlycoproteinsConceptsGerm cell nuclear factorBMP-15Bone morphogenetic protein 15New regulatory pathwayFemale fertilityGDF-9Growth differentiation factor 9DR0 elementsDifferentiation factor 9Knockout mouse modelSomatic cellsGene promoterRegulatory pathwaysReproductive defectsReporter activityFemale reproductionMolecular studiesFactor 9Paracrine communicationProtein 15Nuclear factorAberrant steroidogenesisExpressionOocytesPrimary defect