2024
Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease
Zhou X, Shen X, Johnson J, Spakowicz D, Agnello M, Zhou W, Avina M, Honkala A, Chleilat F, Chen S, Cha K, Leopold S, Zhu C, Chen L, Lyu L, Hornburg D, Wu S, Zhang X, Jiang C, Jiang L, Jiang L, Jian R, Brooks A, Wang M, Contrepois K, Gao P, Rose S, Tran T, Nguyen H, Celli A, Hong B, Bautista E, Dorsett Y, Kavathas P, Zhou Y, Sodergren E, Weinstock G, Snyder M. Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease. Cell Host & Microbe 2024, 32: 506-526.e9. PMID: 38479397, PMCID: PMC11022754, DOI: 10.1016/j.chom.2024.02.012.Peer-Reviewed Original ResearchHost healthMicrobiome dynamicsBacterial taxaBody sitesMicrobiome stabilityIndividual taxaHuman microbiomeMicrobial compositionMicrobial dynamicsMulti-omicsNasal microbiomeMicrobiomeDisrupt interactionsMolecular markersBody-sitesTaxaHostMetabolic diseasesOral microbiomeInsulin-resistant individualsIndividual-specificTemporal dynamicsClinical featuresComprehensive viewClinical markers
1993
Identification and Characterization of an Alu-Containing, T-Cell-Specific Enhancer Located in the Last Intron of the Human CD8α Gene
Hambor J, Mennone J, Coon M, Hanke J, Kavathas P. Identification and Characterization of an Alu-Containing, T-Cell-Specific Enhancer Located in the Last Intron of the Human CD8α Gene. Molecular And Cellular Biology 1993, 13: 7056-7070. DOI: 10.1128/mcb.13.11.7056-7070.1993.Peer-Reviewed Original ResearchT cell-specific enhancerLyF-1Regulatory elementsHypersensitive sitesBinding sitesCD8A geneDNase I hypersensitivity mappingCis-acting regulatory regionsEts-1Consensus binding siteElectrophoretic mobility shift assayNegative regulatory elementDNA sequence analysisSite-directed mutationsGATA-3 sitesReduced enhancer activityMobility shift assayTissue-specific expressionGATA-3Combinations of mutationsBHLH proteinsAlu repeatsChromatin structureT cell genesRegulatory regions