Identification and Characterization of an Alu-Containing, T-Cell-Specific Enhancer Located in the Last Intron of the Human CD8α Gene
Hambor J, Mennone J, Coon M, Hanke J, Kavathas P. Identification and Characterization of an Alu-Containing, T-Cell-Specific Enhancer Located in the Last Intron of the Human CD8α Gene. Molecular And Cellular Biology 1993, 13: 7056-7070. DOI: 10.1128/mcb.13.11.7056-7070.1993.Peer-Reviewed Original ResearchT cell-specific enhancerLyF-1Regulatory elementsHypersensitive sitesBinding sitesCD8A geneDNase I hypersensitivity mappingCis-acting regulatory regionsEts-1Consensus binding siteElectrophoretic mobility shift assayNegative regulatory elementDNA sequence analysisSite-directed mutationsGATA-3 sitesReduced enhancer activityMobility shift assayTissue-specific expressionGATA-3Combinations of mutationsBHLH proteinsAlu repeatsChromatin structureT cell genesRegulatory regions