AP2α alters the transcriptional activity and stability of p53
Stabach P, Thiyagarajan M, Woodfield G, Weigel R. AP2α alters the transcriptional activity and stability of p53. Oncogene 2005, 25: 2148-2159. PMID: 16288208, DOI: 10.1038/sj.onc.1209250.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsChromatin ImmunoprecipitationColonic NeoplasmsCyclin-Dependent Kinase Inhibitor p21Gene Expression Regulation, NeoplasticGenes, ReporterHumansImmunoprecipitationLiver NeoplasmsPoint MutationPromoter Regions, GeneticProtein BindingTranscription Factor AP-2Transcription, GeneticTranscriptional ActivationTumor Cells, CulturedTumor Suppressor Protein p53ConceptsTranscriptional activityEndogenous p53 target genesEndogenous p21 geneNormal transcriptional activityP53 target genesP53-mediated inductionAmino acids 305Stability of p53Expression of aP2Transcriptional coactivationP21WAF1/CIP1P21 promoterTarget genesCertain genesRegion of p53AP2αReporter assaysP21 geneFunctional partnershipP53 stabilityP53 activityCell growthPoint mutationsAP2GenesExpression of ZER6 in ERα-Positive Breast Cancer
Stabach P, Thiyagarajan M, Weigel R. Expression of ZER6 in ERα-Positive Breast Cancer. Journal Of Surgical Research 2005, 126: 86-91. PMID: 15916980, DOI: 10.1016/j.jss.2005.02.006.Peer-Reviewed Original ResearchConceptsBreast cancerBreast carcinoma cellsERalpha-positive breast cancer cellsERalpha-negative breast cancersHormone-responsive breast cancerPrimary breast cancer tissuesERα-positive breast cancerERalpha-negative tumorsERalpha-positive tumorsCarcinoma cellsPrimary breast cancerERalpha-positive cell linesBreast cancer tissuesBreast cancer cellsERalpha expressionCancer tissuesCancerWestern blotRT-PCRCancer cellsLigand-dependent interactionCell linesTranscription factorsExpression of genesTumors