2021
In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker
Mody M, Petibon Y, Han P, Kuruppu D, Ma C, Yokell D, Neelamegam R, Normandin M, Fakhri G, Brownell A. In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker. Scientific Reports 2021, 11: 15897. PMID: 34354107, PMCID: PMC8342610, DOI: 10.1038/s41598-021-94967-y.Peer-Reviewed Original ResearchConceptsFragile X syndromeFragile X mental retardation proteinX syndromeLoss of fragile X mental retardation proteinMGlu5 receptor expressionMetabotropic glutamate subtype 5 receptorsDrug occupancy studiesSignificant group differencesFragile X mental retardationHealthy controlsAnterior cingulateMGluR5 availabilityVisuospatial processingMGlu5 receptorsOlfactory cortexBrain areasGroup differencesRetardation proteinGlutamate signalingImages of maleNeurodevelopmental disordersExcessive glutamate signalingGender-matched controlsDisordersMGluR5
2020
Evaluation of the potassium channel tracer [18F]3F4AP in rhesus macaques
Guehl N, Ramos-Torres K, Linnman C, Moon S, Dhaynaut M, Wilks M, Han P, Ma C, Neelamegam R, Zhou Y, Popko B, Correia J, Reich D, Fakhri G, Herscovitch P, Normandin M, Brugarolas P. Evaluation of the potassium channel tracer [18F]3F4AP in rhesus macaques. Cerebrovascular And Brain Metabolism Reviews 2020, 41: 1721-1733. PMID: 33090071, PMCID: PMC8221756, DOI: 10.1177/0271678x20963404.Peer-Reviewed Original ResearchConceptsFocal brain injuryMyelin repair therapyContributions of demyelinationDrivers of disabilityImaging demyelinationBrain injuryMeasurements of molecular changesTool's sensitivity to changesLower myelin contentDemyelinating lesionsNeuronal conductionImpaired conductionDemyelinationBrain penetrationGold standardRhesus macaquesInjured areaMultiple sclerosisMolecular changesMyelin sheathNeurological diseasesHigh metabolic stabilityMRI methodsMRIInjury
2016
DC artifact correction for arbitrary phase-cycling sequence
Han P, Park H, Park S. DC artifact correction for arbitrary phase-cycling sequence. Magnetic Resonance Imaging 2016, 38: 21-26. PMID: 27998747, DOI: 10.1016/j.mri.2016.12.015.Peer-Reviewed Original Research
2015
Whole‐brain perfusion imaging with balanced steady‐state free precession arterial spin labeling
Han P, Ye J, Kim E, Choi S, Park S. Whole‐brain perfusion imaging with balanced steady‐state free precession arterial spin labeling. NMR In Biomedicine 2015, 29: 264-274. PMID: 26676386, DOI: 10.1002/nbm.3463.Peer-Reviewed Original ResearchConceptsSignal-to-noise ratioBalanced steady-state free precessionTotal scan timeCompressive sensingReduced susceptibility artifactsPerfusion imagingWhole-brain perfusion imagingScan timeSusceptibility artifactsPseudo-continuous ASLReadout timeCS approachSteady-state free precessionAcquisition of perfusion imagesSegmentation approachFree precessionBSSFP readoutArterial spin labeling (ASL) perfusionSpatial resolutionImage qualityDistortion-freeReadoutHigh-resolutionTemporal resolutionImagesCompressed Sensing for fMRI: Feasibility Study on the Acceleration of Non‐EPI fMRI at 9.4T
Han P, Park S, Kim S, Ye J. Compressed Sensing for fMRI: Feasibility Study on the Acceleration of Non‐EPI fMRI at 9.4T. BioMed Research International 2015, 2015: 131926. PMID: 26413503, PMCID: PMC4564593, DOI: 10.1155/2015/131926.Peer-Reviewed Original ResearchConceptsCompressive sensingBalanced steady-state free precessionSensitive to image distortionsHigh-resolution fMRI techniqueMagnetic field inhomogeneityLocal magnetic field inhomogeneitiesConventional functional magnetic resonance imagingCS reconstructionGradient-recalled echoCS algorithmFOCUSS algorithmNon-EPI sequencesMagnetic fieldSampling patternHigh-resolution functional magnetic resonance imagingFunctional magnetic resonance imagingField inhomogeneityGRE-EPIImage distortionSteady-state free precessionExperimental resultsTemporal resolutionAlgorithmFree precessionSpoiled gradient echo