2017
Emergency Department-Initiated Buprenorphine for Opioid Dependence with Continuation in Primary Care: Outcomes During and After Intervention
D’Onofrio G, Chawarski MC, O’Connor P, Pantalon MV, Busch SH, Owens PH, Hawk K, Bernstein SL, Fiellin DA. Emergency Department-Initiated Buprenorphine for Opioid Dependence with Continuation in Primary Care: Outcomes During and After Intervention. Journal Of General Internal Medicine 2017, 32: 660-666. PMID: 28194688, PMCID: PMC5442013, DOI: 10.1007/s11606-017-3993-2.Peer-Reviewed Original ResearchConceptsIllicit opioid useOpioid usePrimary careHIV riskBrief interventionAddiction treatmentBuprenorphine groupEmergency Department-Initiated BuprenorphineCohort of patientsLong-term followLong-term outcomesFormal addiction treatmentSignificant differencesMain MeasuresSelfStudy entryUrine toxicologyBuprenorphine/Opioid dependenceED interventionsUrine resultsBuprenorphineTreatment engagementDrug useReferralPatients
2012
Development of a scale to measure practitioner adherence to a brief intervention in the emergency department
Pantalon MV, Martino S, Dziura J, Li FY, Owens PH, Fiellin DA, O'Connor PG, D'Onofrio G. Development of a scale to measure practitioner adherence to a brief intervention in the emergency department. Journal Of Substance Use And Addiction Treatment 2012, 43: 382-388. PMID: 23021098, PMCID: PMC3661016, DOI: 10.1016/j.jsat.2012.08.011.Peer-Reviewed Original ResearchConceptsBrief Negotiation InterviewBrief interventionTwo-factor structureExcellent internal consistencyGood construct validityDiscriminant validityPredictive validityEmergency departmentExcellent inter-rater reliabilityPsychometric propertiesEight-itemConstruct validityHazardous drinkingInternal consistencyEmergency department patientsPractitioner adherenceInter-rater reliabilityDepartment patientsAdherence ScaleClinical practiceValidityInterventionSkillsAdherenceScaleBrief versus extended counseling along with buprenorphine/naloxone for HIV-infected opioid dependent patients
Tetrault JM, Moore BA, Barry DT, O'Connor PG, Schottenfeld R, Fiellin DA, Fiellin LE. Brief versus extended counseling along with buprenorphine/naloxone for HIV-infected opioid dependent patients. Journal Of Substance Use And Addiction Treatment 2012, 43: 433-439. PMID: 22938914, DOI: 10.1016/j.jsat.2012.07.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultBuprenorphineBuprenorphine, Naloxone Drug CombinationCounselingDelivery of Health Care, IntegratedFeasibility StudiesFemaleFollow-Up StudiesHIV InfectionsHumansMaleMiddle AgedNaloxoneNarcotic AntagonistsOpioid-Related DisordersPsychotherapy, BriefSubstance Abuse DetectionTime FactorsTreatment OutcomeViral LoadConceptsEnhanced medical managementPhysician managementDetectable HIV viral loadHIV treatment settingsOpioid-negative urinesBuprenorphine/naloxoneHIV viral loadOpioid-dependent patientsPercentage of subjectsUntreated opioid dependenceExtended counselingHIV clinicHIV outcomesBuprenorphine/Medical managementOpioid dependenceViral loadDependent patientsExtensive counselingClinical trialsContinuous abstinenceNegative urineTreatment settingsGroup differencesCounseling
2008
Long‐Term Treatment with Buprenorphine/Naloxone in Primary Care: Results at 2–5 Years
Fiellin DA, Moore BA, Sullivan LE, Becker WC, Pantalon MV, Chawarski MC, Barry DT, O'Connor PG, Schottenfeld RS. Long‐Term Treatment with Buprenorphine/Naloxone in Primary Care: Results at 2–5 Years. American Journal On Addictions 2008, 17: 116-120. PMID: 18393054, DOI: 10.1080/10550490701860971.Peer-Reviewed Original ResearchMeSH KeywordsAdultBuprenorphineCombined Modality TherapyCounselingCross-Sectional StudiesDose-Response Relationship, DrugDrug Administration ScheduleDrug Therapy, CombinationFemaleFollow-Up StudiesHeroin DependenceHumansLong-Term CareMaleMiddle AgedNaloxoneNarcotic AntagonistsOpioid-Related DisordersPatient DropoutsPrimary Health CareSubstance Abuse DetectionTreatment OutcomeConceptsOpioid-dependent patientsAdverse eventsSerum transaminasesBuprenorphine/naloxone treatmentSerious adverse eventsBuprenorphine/naloxoneLong-term outcomesOffice-based treatmentIllicit drug useOpioid useClinical stabilityNaloxone treatmentPrimary outcomePatient satisfactionPrimary careTerm treatmentDrug useUrine samplesPatientsTreatmentTransaminaseOutcomesYearsModerate levelsPercent
2006
A Trial of Integrated Buprenorphine/Naloxone and HIV Clinical Care
Sullivan LE, Barry D, Moore BA, Chawarski MC, Tetrault JM, Pantalon MV, O'Connor PG, Schottenfeld RS, Fiellin DA. A Trial of Integrated Buprenorphine/Naloxone and HIV Clinical Care. Clinical Infectious Diseases 2006, 43: s184-s190. PMID: 17109305, DOI: 10.1086/508182.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, SublingualAdultAntiretroviral Therapy, Highly ActiveBuprenorphineDose-Response Relationship, DrugDrug Administration ScheduleFemaleFollow-Up StudiesHIV InfectionsHumansMaleMiddle AgedNaloxoneNarcotic AntagonistsOpioid-Related DisordersPilot ProjectsProbabilityReference ValuesRisk FactorsTreatment OutcomeConceptsHIV clinical careHIV-1 RNA copies/mLBuprenorphine/naloxone treatmentRNA copies/mLCopies/mLOpioid dependenceClinical careOpioid useNaloxone treatmentPhysician managementTreatment retentionHIV type 1 RNA levelsHIV-1 RNA levelsDose of buprenorphinePartial opioid agonistRNA levelsCD4 lymphocyte countBuprenorphine/naloxoneOpioid-dependent patientsUrine toxicology testsWeeks of treatmentHuman immunodeficiency virusUrine test resultsBetter treatment retentionUntreated opioid dependenceA Randomized Trial of Primary Intensive Care to Reduce Hospital Admissions in Patients with High Utilization of Inpatient Services
Sledge WH, Brown KE, Levine JM, Fiellin DA, Chawarski M, White WD, O'Connor PG. A Randomized Trial of Primary Intensive Care to Reduce Hospital Admissions in Patients with High Utilization of Inpatient Services. Population Health Management 2006, 9: 328-338. PMID: 17115880, DOI: 10.1089/dis.2006.9.328.Peer-Reviewed Original ResearchConceptsHospital admissionIntensive careFunctional statusInpatient servicesHealth outcomesUrban primary care clinicFrequent hospital admissionsEmergency department visitsMedication Adherence ScalePrimary care patientsPrimary care clinicsHealth care useRandomized clinical trialsOverall functional statusCase management interventionComprehensive multidisciplinary assessmentNumber of admissionsMental health functionPIC patientsUsual careClinic visitsCare patientsControlled TrialsDepartment visitsCare clinics
2005
Primary Intensive Care: Pilot Study of a Primary CareBased Intervention for High-Utilizing Patients
Brown KE, Levine JM, Fiellin DA, O'connor P, Sledge WH. Primary Intensive Care: Pilot Study of a Primary CareBased Intervention for High-Utilizing Patients. Population Health Management 2005, 8: 169-177. PMID: 15966782, DOI: 10.1089/dis.2005.8.169.Peer-Reviewed Original ResearchConceptsPilot studyHospital cost differencesWeekly multidisciplinary clinicHigher healthcare utilizationPrimary care patientsEmergency department usePrimary care centersPresence of psychopathologyManagement patientsCare patientsHealthcare utilizationMultidisciplinary clinicIntensive careDepartment useCare centerInpatient servicesPatientsPsychiatric diagnosisSpecial interventionStaff satisfactionStatistical significanceInterventionClinicCost differencesDiagnosis
1993
The impact of gender on clinical characteristics and outcome in alcohol withdrawal
O'Connor P, Horwitz R, Gottlieb L, Kraus M, Segal S. The impact of gender on clinical characteristics and outcome in alcohol withdrawal. Journal Of Substance Use And Addiction Treatment 1993, 10: 59-61. PMID: 8450575, DOI: 10.1016/0740-5472(93)90099-n.Peer-Reviewed Original ResearchConceptsSimilar treatment outcomesAlcohol withdrawalClinical featuresTreatment outcomesMean daily alcohol intakeHigh treatment failure rateTreatment failure rateDaily alcohol intakeTerms of baselineOutpatient withdrawalClinical characteristicsAlcohol intakeAlcohol abuseSociodemographic featuresPatientsWomenMenWithdrawalImpact of genderShort durationOutcomesTreatmentFailure rateGenderAlcoholism