2022
Perspectives About Emergency Department Care Encounters Among Adults With Opioid Use Disorder
Hawk K, McCormack R, Edelman EJ, Coupet E, Toledo N, Gauthier P, Rotrosen J, Chawarski M, Martel S, Owens P, Pantalon MV, O’Connor P, Whiteside LK, Cowan E, Richardson LD, Lyons MS, Rothman R, Marsch L, Fiellin DA, D’Onofrio G. Perspectives About Emergency Department Care Encounters Among Adults With Opioid Use Disorder. JAMA Network Open 2022, 5: e2144955. PMID: 35076700, PMCID: PMC8790663, DOI: 10.1001/jamanetworkopen.2021.44955.Peer-Reviewed Original ResearchConceptsUntreated opioid use disorderOpioid use disorderEmergency departmentED visitsOUD treatmentUse disordersPublic safety-net hospitalRural critical access hospitalsEmergency department careSafety-net hospitalUrban academic centerLife-saving treatmentCritical access hospitalsImplementation science frameworkPatient factorsTreatment initiationED careUS patientsStaff trainingDemand treatmentPatient readinessNet hospitalPatient's perspectivePromoting ActionImproved careThe Impact of Access to Addiction Specialist on Attitudes, Beliefs and Hospital-Based Opioid Use Disorder Related Care: A Survey of Hospitalist Physicians
Calcaterra SL, Binswanger IA, Edelman EJ, McNair BK, Wakeman SE, O'Connor P. The Impact of Access to Addiction Specialist on Attitudes, Beliefs and Hospital-Based Opioid Use Disorder Related Care: A Survey of Hospitalist Physicians. Substance Use & Addiction Journal 2022, 43: 143-151. PMID: 32267807, PMCID: PMC7541600, DOI: 10.1080/08897077.2020.1748169.Peer-Reviewed Original ResearchConceptsOpioid use disorderAddiction specialistsLocal treatment resourcesLife-saving treatmentBuprenorphine initiationMultivariable analysisOUD careScreening practicesHospitalist physiciansUse disordersClinical practicePatientsRelated careTreatment resourcesHospitalistsHarm reductionCareTreatmentUnited StatesSpecialistsOnline surveyHospitalizationBuprenorphineComplicationsPrescribing
2021
Association of Socioeconomic Status With Alpha Omega Alpha Honor Society Membership Among Medical Students
Nguyen M, Mason HRC, O’Connor P, Nunez-Smith M, McDade WA, Latimore D, Boatright D. Association of Socioeconomic Status With Alpha Omega Alpha Honor Society Membership Among Medical Students. JAMA Network Open 2021, 4: e2110730. PMID: 34076702, PMCID: PMC8173376, DOI: 10.1001/jamanetworkopen.2021.10730.Peer-Reviewed Original Research
2020
Addiction Psychiatry and Addiction Medicine: The Evolution of Addiction Physician Specialists
Nunes EV, Kunz K, Galanter M, O'Connor PG. Addiction Psychiatry and Addiction Medicine: The Evolution of Addiction Physician Specialists. American Journal On Addictions 2020, 29: 390-400. PMID: 32902056, DOI: 10.1111/ajad.13068.Peer-Reviewed Original ResearchConceptsSubstance use disordersAddiction medicineUse disordersAddiction psychiatryAddiction medicine fellowshipsAmerican BoardPublic health challengeWorkforce of physiciansMedical comorbiditiesGeneral medicalSpecialty settingsPhysician specialistsClinical settingPractice pathwayHealth challengesPrimary specialtyFellowship trainingPreventive medicineActive diplomatesMedical specialtiesTraining program requirementsAccreditation CouncilDisordersMedicineDiplomatesRacial Privilege and Medical Student Awards: Addressing Racial Disparities in Alpha Omega Alpha Honor Society Membership
Boatright D, O’Connor P, E. Miller J. Racial Privilege and Medical Student Awards: Addressing Racial Disparities in Alpha Omega Alpha Honor Society Membership. Journal Of General Internal Medicine 2020, 35: 3348-3351. PMID: 32869203, PMCID: PMC7661606, DOI: 10.1007/s11606-020-06161-x.Peer-Reviewed Original ResearchConceptsRacial disparitiesUse of Amphetamine-Type Stimulants Among Emergency Department Patients With Untreated Opioid Use Disorder
Chawarski MC, Hawk K, Edelman EJ, O'Connor P, Owens P, Martel S, Coupet E, Whiteside L, Tsui JI, Rothman R, Cowan E, Richardson L, Lyons MS, Fiellin DA, D'Onofrio G. Use of Amphetamine-Type Stimulants Among Emergency Department Patients With Untreated Opioid Use Disorder. Annals Of Emergency Medicine 2020, 76: 782-787. PMID: 32782084, PMCID: PMC8048036, DOI: 10.1016/j.annemergmed.2020.06.046.Peer-Reviewed Original ResearchConceptsUntreated opioid use disorderOpioid use disorderAmphetamine-type stimulant useUse disordersStimulant useAmphetamine-type stimulantsStudy admissionEmergency departmentEmergency department patientsImplementation science studyUrine test resultsFalse discovery rate correctionSubstance use problemsHepatitis CED visitsDepartment patientsReferral protocolsED patientsUrine testsDrug injectionOverdose riskPatientsHealth factorsUnstable housingConcurrent useBarriers and Facilitators to Clinician Readiness to Provide Emergency Department–Initiated Buprenorphine
Hawk KF, D’Onofrio G, Chawarski MC, O’Connor P, Cowan E, Lyons MS, Richardson L, Rothman RE, Whiteside LK, Owens PH, Martel SH, Coupet E, Pantalon M, Curry L, Fiellin DA, Edelman EJ. Barriers and Facilitators to Clinician Readiness to Provide Emergency Department–Initiated Buprenorphine. JAMA Network Open 2020, 3: e204561. PMID: 32391893, PMCID: PMC7215257, DOI: 10.1001/jamanetworkopen.2020.4561.Peer-Reviewed Original ResearchConceptsOpioid use disorderEmergency departmentAdvanced practice cliniciansED cliniciansClinicians' readinessOngoing treatmentTreatment of OUDEmergency Department-Initiated BuprenorphineUntreated opioid use disorderDrug Addiction Treatment ActDecrease opioid useVisual analog scaleHealth Services frameworkAcademic emergency departmentMixed-methods formative evaluationQuality of careSubset of participantsBuprenorphine initiationClinician typeOpioid useED patientsAnalog scaleOngoing careDepartmental protocolPractice clinicians
2019
Integrated stepped alcohol treatment for patients with HIV and alcohol use disorder: a randomised controlled trial
Edelman EJ, Maisto SA, Hansen NB, Cutter CJ, Dziura J, Deng Y, Fiellin LE, O'Connor PG, Bedimo R, Gibert CL, Marconi VC, Rimland D, Rodriguez-Barradas MC, Simberkoff MS, Tate JP, Justice AC, Bryant KJ, Fiellin DA. Integrated stepped alcohol treatment for patients with HIV and alcohol use disorder: a randomised controlled trial. The Lancet HIV 2019, 6: e509-e517. PMID: 31109915, PMCID: PMC7161741, DOI: 10.1016/s2352-3018(19)30076-1.Peer-Reviewed Original ResearchConceptsAlcohol use disorderWeek 24Use disordersAlcohol treatmentAdverse eventsNumber of drinksTreatment medicationsPhysician managementAlcohol abuseMental Disorders-IV criteriaAlcohol-related careFormal alcohol treatmentKey exclusion criteriaTimeline followback methodMotivational enhancement therapyTreat populationHIV clinicHIV outcomesPrimary outcomeSpecialty referralsMean ageUS National InstitutesWeek 4Medical conditionsExclusion criteriaImplementation facilitation to promote emergency department-initiated buprenorphine for opioid use disorder: protocol for a hybrid type III effectiveness-implementation study (Project ED HEALTH)
D’Onofrio G, Edelman EJ, Hawk KF, Pantalon MV, Chawarski MC, Owens PH, Martel SH, VanVeldhuisen P, Oden N, Murphy SM, Huntley K, O’Connor P, Fiellin DA. Implementation facilitation to promote emergency department-initiated buprenorphine for opioid use disorder: protocol for a hybrid type III effectiveness-implementation study (Project ED HEALTH). Implementation Science 2019, 14: 48. PMID: 31064390, PMCID: PMC6505286, DOI: 10.1186/s13012-019-0891-5.Peer-Reviewed Original ResearchConceptsOpioid use disorderEmergency departmentImplementation facilitationCost-effectiveness analysisUse disordersPatient engagementEmergency department-initiated buprenorphineEffectiveness-implementation studyEvaluation periodOpioid agonist treatmentSoft tissue infectionsInjection drug useGeneral medical conditionsHealth Services frameworkClinical Trials NetworkAcademic emergency departmentRate of provisionIF interventionOngoing medicationED visitsTissue infectionsED patientsFacilitated referralAgonist treatmentED providers
2017
Past‐year Prescription Drug Monitoring Program Opioid Prescriptions and Self‐reported Opioid Use in an Emergency Department Population With Opioid Use Disorder
Hawk K, D'Onofrio G, Fiellin DA, Chawarski MC, O'Connor PG, Owens PH, Pantalon MV, Bernstein SL. Past‐year Prescription Drug Monitoring Program Opioid Prescriptions and Self‐reported Opioid Use in an Emergency Department Population With Opioid Use Disorder. Academic Emergency Medicine 2017, 25: 508-516. PMID: 29165853, PMCID: PMC5963969, DOI: 10.1111/acem.13352.Peer-Reviewed Original ResearchConceptsPrescription drug monitoring programsOpioid use disorderNonmedical prescription opioid usePrescription opioid useAberrant drug-related behaviorsOpioid useOpioid prescriptionsUse disordersED patientsDrug-related behaviorsPrescription recordsState prescription drug monitoring programStatistical Manual IV criteriaNonmedical opioid useRandomized clinical trialsEmergency department assessmentEmergency department populationDrug monitoring programsCharacteristics of participantsUrban EDOpioid dependencePrescription opioidsPDMP dataTreatment trialsClinical historyCost‐effectiveness of emergency department‐initiated treatment for opioid dependence
Busch SH, Fiellin DA, Chawarski MC, Owens PH, Pantalon MV, Hawk K, Bernstein SL, O'Connor PG, D'Onofrio G. Cost‐effectiveness of emergency department‐initiated treatment for opioid dependence. Addiction 2017, 112: 2002-2010. PMID: 28815789, PMCID: PMC5657503, DOI: 10.1111/add.13900.Peer-Reviewed Original ResearchConceptsCost-effectiveness acceptability curvesOpioid dependenceCommunity-based treatmentBrief interventionAcceptability curvesPast weekHealth care system costsHealth care system perspectiveAddiction treatmentOpioid-dependent patientsPatient time costsHealth care useFormal addiction treatmentBuprenorphine treatmentUrban EDEmergency departmentPrimary carePatient engagementTreatment engagementPatientsReferralSecondary analysisBuprenorphineNumber of daysIntervention
2016
Implementation of integrated stepped care for unhealthy alcohol use in HIV clinics
Edelman EJ, Hansen NB, Cutter CJ, Danton C, Fiellin LE, O’Connor P, Williams EC, Maisto SA, Bryant KJ, Fiellin DA. Implementation of integrated stepped care for unhealthy alcohol use in HIV clinics. Addiction Science & Clinical Practice 2016, 11: 1. PMID: 26763048, PMCID: PMC4711105, DOI: 10.1186/s13722-015-0048-z.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useHIV clinicAlcohol usePatient motivationIntervention characteristicsInner settingHIV treatment settingsImplementation Research domainsModel of careCharacteristics of individualsAddiction psychiatristsCare modelCFIR frameworkTreatment settingsCFIR domainsMultidisciplinary teamClinicConsolidated FrameworkImplementation themesPatientsProvider perspectivesCareEffective counselingSocial workersIntervention
2015
An analysis of moderators in the COMBINE study: Identifying subgroups of patients who benefit from acamprosate
Gueorguieva R, Wu R, Tsai WM, O’Connor P, Fucito L, Zhang H, O’Malley S. An analysis of moderators in the COMBINE study: Identifying subgroups of patients who benefit from acamprosate. European Neuropsychopharmacology 2015, 25: 1586-1599. PMID: 26141511, PMCID: PMC4600651, DOI: 10.1016/j.euroneuro.2015.06.006.Peer-Reviewed Original ResearchConceptsAcamprosate effectHeavy drinkingShort abstinenceEnhanced treatment responseMonths of treatmentSubgroup of patientsBody mass indexDrug plasma levelsIdentification of subgroupsBetter prognosisLower BMIMass indexPlasma levelsGlutamatergic hyperactivityTreatment responseAcamprosateCOMBINE StudyPrior treatmentLarger studyConsecutive daysAbstinencePretreatment abstinenceTreatment effectsCognitive inefficiencySubgroups
2014
Predictors of Abstinence from Heavy Drinking During Treatment in COMBINE and External Validation in PREDICT
Gueorguieva R, Wu R, O'Connor PG, Weisner C, Fucito LM, Hoffmann S, Mann K, O'Malley SS. Predictors of Abstinence from Heavy Drinking During Treatment in COMBINE and External Validation in PREDICT. Alcohol Clinical And Experimental Research 2014, 38: 2647-2656. PMID: 25346505, PMCID: PMC4397985, DOI: 10.1111/acer.12541.Peer-Reviewed Original ResearchAcamprosateAge FactorsAlcohol AbstinenceAlcohol DeterrentsAlcohol DrinkingBehavior TherapyCombined Modality TherapyControlled Clinical Trials as TopicDecision TreesGamma-GlutamyltransferaseGermanyGoalsHumansLogistic ModelsMiddle AgedNaltrexonePredictive Value of TestsRandomized Controlled Trials as TopicReproducibility of ResultsTaurineTime FactorsTreatment OutcomeUnited States
2012
Developing and Implementing a Multispecialty Graduate Medical Education Curriculum on Screening, Brief Intervention, and Referral to Treatment (SBIRT)
Tetrault JM, Green ML, Martino S, Thung SF, Degutis LC, Ryan SA, Martel S, Pantalon MV, Bernstein SL, O'Connor P, Fiellin DA, D'Onofrio G. Developing and Implementing a Multispecialty Graduate Medical Education Curriculum on Screening, Brief Intervention, and Referral to Treatment (SBIRT). Substance Use & Addiction Journal 2012, 33: 168-181. PMID: 22489589, DOI: 10.1080/08897077.2011.640220.Peer-Reviewed Original ResearchConceptsBrief interventionInternal medicineEmergency medicineMean satisfaction scoreMultiple residency programsStandardized patient sessionSBIRT curriculumClinical practicePediatric programsSBIRTSatisfaction scoresClinical encountersPatient sessionsPediatric residentsProject facultyTraining Web siteStandardized patientsReferralGynecologyObstetricsNumber of residentsResidency programsSatisfaction surveyGraduate medical education curriculumFaculty supervision
2010
The Safety of Opioid Analgesics in the Elderly: New Data Raise New Concerns: Comment on “The Comparative Safety of Opioids for Nonmalignant Pain in Older Adults”
Becker WC, O'Connor PG. The Safety of Opioid Analgesics in the Elderly: New Data Raise New Concerns: Comment on “The Comparative Safety of Opioids for Nonmalignant Pain in Older Adults”. JAMA Internal Medicine 2010, 170: 1986-1988. PMID: 21149755, DOI: 10.1001/archinternmed.2010.443.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnalgesics, OpioidAnti-Inflammatory Agents, Non-SteroidalCardiovascular DiseasesComorbidityContraindicationsCyclooxygenase 2 InhibitorsDrug UtilizationFemaleFractures, BoneGastrointestinal HemorrhageHumansMaleMedicareObservationPainPain MeasurementResearch DesignTherapeutic EquivalencyUnited StatesAdvances in the Treatment of Opioid Dependence: Continued Progress and Ongoing Challenges
O’Connor P. Advances in the Treatment of Opioid Dependence: Continued Progress and Ongoing Challenges. JAMA 2010, 304: 1612-1614. PMID: 20940391, DOI: 10.1001/jama.2010.1496.Peer-Reviewed Original Research
2008
Substance Abuse and Withdrawal in the Critical Care Setting
Tetrault JM, O'Connor PG. Substance Abuse and Withdrawal in the Critical Care Setting. Critical Care Clinics 2008, 24: 767-788. PMID: 18929942, DOI: 10.1016/j.ccc.2008.05.005.Commentaries, Editorials and LettersConceptsCritical care settingWithdrawal syndromeCare settingsOverall treatment protocolSubstance useSubstance withdrawal syndromeSymptom-triggered approachCritical care teamTapering doseAcute presentationResuscitative measuresCare teamTreatment protocolHigh indexSubstance intoxicationSubstance abuseAbused drugsSyndromeTreatmentWithdrawalEpidemiologySettingSuspicionDoseIntoxication
2007
Systematic review: opioid treatment for chronic back pain: prevalence, efficacy, and association with addiction.
Martell BA, O'Connor PG, Kerns RD, Becker WC, Morales KH, Kosten TR, Fiellin DA. Systematic review: opioid treatment for chronic back pain: prevalence, efficacy, and association with addiction. Annals Of Internal Medicine 2007, 146: 116-27. PMID: 17227935, DOI: 10.7326/0003-4819-146-2-200701160-00006.Peer-Reviewed Original ResearchConceptsChronic back painSubstance use disordersEfficacy of opioidsBack painMedication-taking behaviorUse disordersOpioid treatmentOpioid medicationsStudy qualityShort-term pain reliefCurrent substance use disorderCochrane Central RegisterLifetime substance use disorderControlled Clinical TrialsLong-term efficacyPoor study qualityEnglish-language studiesTransdermal opioidsOpioid prescribingPain reliefCentral RegisterDifferent opioidsReduced painClinical trialsNonsignificant reduction
2004
Processes of Care During a Randomized Trial of Office‐based Treatment of Opioid Dependence in Primary Care
Fiellin DA, O'Connor PG, Chawarski M, Schottenfeld RS. Processes of Care During a Randomized Trial of Office‐based Treatment of Opioid Dependence in Primary Care. American Journal On Addictions 2004, 13: s67-s78. PMID: 15204676, DOI: 10.1080/10550490490440843.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultFemaleFocus GroupsHumansMaleMedical AuditMethadoneMiddle AgedMulticenter Studies as TopicNarcoticsOffice VisitsOpioid-Related DisordersOutcome and Process Assessment, Health CarePrimary Health CareProcess Assessment, Health CareQuality Assurance, Health CareRandomized Controlled Trials as TopicReferral and ConsultationSubstance Abuse DetectionTreatment RefusalUnited StatesConceptsUrine toxicology resultsProcess of careOpioid dependenceChart auditToxicology resultsOpioid treatment programsOffice-based careOffice-based treatmentDependent patientsMethadone maintenancePrimary carePsychiatric servicesFocus groupsQuality careTreatment programCareTreatmentTrialsAuditMedicationsBuprenorphinePatientsMethadoneGroupEvaluation of processes