2015
Addressing Bias in Observational Studies of Alcohol Withdrawal Syndrome: A Call to the Field
Fiellin DA, Samet JH, O'Connor PG. Addressing Bias in Observational Studies of Alcohol Withdrawal Syndrome: A Call to the Field. Alcohol Clinical And Experimental Research 2015, 39: 390-390. PMID: 25665029, DOI: 10.1111/acer.12634.Peer-Reviewed Original Research
2014
Primary Care–Based Buprenorphine Taper vs Maintenance Therapy for Prescription Opioid Dependence: A Randomized Clinical Trial
Fiellin DA, Schottenfeld RS, Cutter CJ, Moore BA, Barry DT, O’Connor P. Primary Care–Based Buprenorphine Taper vs Maintenance Therapy for Prescription Opioid Dependence: A Randomized Clinical Trial. JAMA Internal Medicine 2014, 174: 1947-1954. PMID: 25330017, PMCID: PMC6167926, DOI: 10.1001/jamainternmed.2014.5302.Peer-Reviewed Original ResearchConceptsPrescription opioid dependenceOngoing maintenance therapyIllicit opioid useMaintenance therapyOpioid dependenceBuprenorphine taperBuprenorphine therapyTaper groupMaintenance groupOpioid usePrimary careClinical trialsPrimary care-based treatmentSignificant public health burdenBuprenorphine maintenance therapyOngoing maintenance treatmentPrimary care physiciansEvidence-based guidelinesPrimary care sitesPublic health burdenWeeks of stabilizationHydrochloride therapyOpioid withdrawalBuprenorphine treatmentNaltrexone treatment
2012
Opioid Detoxification and Naltrexone Induction Strategies: Recommendations for Clinical Practice
Sigmon SC, Bisaga A, Nunes EV, O'Connor PG, Kosten T, Woody G. Opioid Detoxification and Naltrexone Induction Strategies: Recommendations for Clinical Practice. The American Journal Of Drug And Alcohol Abuse 2012, 38: 187-199. PMID: 22404717, PMCID: PMC4331107, DOI: 10.3109/00952990.2011.653426.Peer-Reviewed Original ResearchConceptsΜ-opioid receptor antagonist naltrexoneSignificant public health problemDose of buprenorphinePublic health problemLevel of careOral naltrexoneOpioid detoxificationAntagonist naltrexoneOpioid dependencePatient selectionOpioid agonistsAgonist maintenanceAncillary medicationsFavorable outcomeHigh riskTarget doseClinical practiceHealth problemsNaltrexoneExpert cliniciansTreatmentDoseMore researchUseful alternativeBest approach
2008
Substance Abuse and Withdrawal in the Critical Care Setting
Tetrault JM, O'Connor PG. Substance Abuse and Withdrawal in the Critical Care Setting. Critical Care Clinics 2008, 24: 767-788. PMID: 18929942, DOI: 10.1016/j.ccc.2008.05.005.Commentaries, Editorials and LettersMeSH KeywordsAlcohol Withdrawal SeizuresAnalgesics, OpioidBenzodiazepinesCritical CareHumansSubstance Withdrawal SyndromeSubstance-Related DisordersUnited StatesConceptsCritical care settingWithdrawal syndromeCare settingsOverall treatment protocolSubstance useSubstance withdrawal syndromeSymptom-triggered approachCritical care teamTapering doseAcute presentationResuscitative measuresCare teamTreatment protocolHigh indexSubstance intoxicationSubstance abuseAbused drugsSyndromeTreatmentWithdrawalEpidemiologySettingSuspicionDoseIntoxication
2005
Buprenorphine tablet versus liquid: A clinical trial comparing plasma levels, efficacy, and symptoms
Chawarski MC, Moody DE, Pakes J, O'Connor PG, Schottenfeld RS. Buprenorphine tablet versus liquid: A clinical trial comparing plasma levels, efficacy, and symptoms. Journal Of Substance Use And Addiction Treatment 2005, 29: 307-312. PMID: 16311183, DOI: 10.1016/j.jsat.2005.08.011.Peer-Reviewed Original ResearchConceptsTrough concentrationsPlasma concentrationsOpiate-dependent volunteersIllicit opioid usePeak plasma concentrationBuprenorphine doseBuprenorphine tabletsOpioid useWithdrawal symptomsBuprenorphine levelsPlasma levelsTablet doseClinical trialsLarge intersubjectLiquid formulationStudy participantsIntrasubject variabilityPlasma samplesPeak concentrationTablet formulationLiquid dosesDays of maintenanceSymptomsDoseConcentration curveMethods of Detoxification and Their Role in Treating Patients With Opioid Dependence
O’Connor P. Methods of Detoxification and Their Role in Treating Patients With Opioid Dependence. JAMA 2005, 294: 961-963. PMID: 16118388, DOI: 10.1001/jama.294.8.961.Peer-Reviewed Original Research
2003
Management of Drug and Alcohol Withdrawal
Kosten TR, O'Connor PG. Management of Drug and Alcohol Withdrawal. New England Journal Of Medicine 2003, 348: 1786-1795. PMID: 12724485, DOI: 10.1056/nejmra020617.Peer-Reviewed Original Research
2002
Risk for Delirium Tremens in Patients with Alcohol Withdrawal Syndrome1
Fiellin DA, O'Connor PG, Holmboe ES, Horwitz RI. Risk for Delirium Tremens in Patients with Alcohol Withdrawal Syndrome1. Substance Abuse 2002, 23: 83-94. PMID: 12444353, DOI: 10.1080/08897070209511478.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAlcohol Withdrawal DeliriumBody TemperatureCase-Control StudiesEthanolFemaleHeart RateHumansHypertensionMaleMiddle AgedRisk FactorsSubstance Withdrawal SyndromeConceptsAdverse clinical featuresDelirium tremensComplicated withdrawalBlood pressureAlcohol withdrawalClinical featuresComplicated alcohol withdrawalElevated blood pressureSystolic blood pressureCase-control studyDSM-IV criteriaComorbidity scoreMedical comorbiditiesDetoxification unitEligibility criteriaTremensWithdrawalRiskComorbiditiesPatientsAdmissionHospitalCasesControl
2000
Pharmacologic treatment of heroin-dependent patients.
O'Connor P, Fiellin D. Pharmacologic treatment of heroin-dependent patients. Annals Of Internal Medicine 2000, 133: 40-54. PMID: 10877739, DOI: 10.7326/0003-4819-133-1-200007040-00008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnalgesics, OpioidBuprenorphineCounselingHeroin DependenceHumansMental DisordersMethadoneMethadyl AcetateNaltrexoneNarcotic AntagonistsPhysician's RoleSubstance Withdrawal SyndromeConceptsHeroin dependenceHeroin-dependent patientsDrug treatment settingsBehavioral health problemsOpioid withdrawalPharmacologic treatmentMethadone maintenanceHeroin usePhysician's officeTreatment approachesTreatment settingsHealth problemsPatientsRelapse preventionTreatmentPhysiciansAcetylmethadolBuprenorphineInternistsReferralDiagnosisAlternative sitesPrevention
1999
Plasma concentrations of buprenorphine 24 to 72 hours after dosing
Chawarski MC, Schottenfeld RS, O’Connor P, Pakes J. Plasma concentrations of buprenorphine 24 to 72 hours after dosing. Drug And Alcohol Dependence 1999, 55: 157-163. PMID: 10402160, DOI: 10.1016/s0376-8716(98)00192-6.Peer-Reviewed Original ResearchConceptsDose scheduleWithdrawal symptomsPlasma concentrationsDaily buprenorphine doseHigh-dose scheduleThrice-weekly scheduleAdministration of buprenorphineOpiate-dependent subjectsHigher plasma concentrationsUse of heroinBuprenorphine doseDaily administrationOutpatient clinicPlasma levelsSublingual administrationAgonist effectsOpiate useHeroin useLow doseHigh doseBuprenorphine solutionMg/70High dosesConcentration 24Dependent subjects
1998
Patients with Alcohol Problems
O'Connor P, Schottenfeld R. Patients with Alcohol Problems. New England Journal Of Medicine 1998, 338: 592-602. PMID: 9475768, DOI: 10.1056/nejm199802263380907.Peer-Reviewed Original ResearchRapid and Ultrarapid Opioid Detoxification Techniques
O'Connor PG, Kosten TR. Rapid and Ultrarapid Opioid Detoxification Techniques. JAMA 1998, 279: 229-234. PMID: 9438745, DOI: 10.1001/jama.279.3.229.Peer-Reviewed Original ResearchMeSH KeywordsClinical Trials as TopicHumansNaloxoneNaltrexoneNarcotic AntagonistsOpioid-Related DisordersResearch DesignSubstance Withdrawal SyndromeConceptsRapid opioid detoxificationControl groupInpatient studyAbstract-only publicationsSubstance withdrawal syndromeLong-term outcomesMethod of treatmentOpioid detoxificationPeer-reviewed journalsWithdrawal syndromeClinical outcomesOpioid dependenceTherapy allocationPharmacologic protocolAnesthesia protocolInclusion criteriaExclusion criteriaNumber of subjectsMEDLINE databaseSubstance abuseRandomized designSubstance dependenceBibliographies of papersMethodologic characteristicsSubject characteristics
1997
Three methods of opioid detoxification in a primary care setting. A randomized trial.
O'Connor PG, Carroll KM, Shi JM, Schottenfeld RS, Kosten TR, Rounsaville BJ. Three methods of opioid detoxification in a primary care setting. A randomized trial. Annals Of Internal Medicine 1997, 127: 526-30. PMID: 9313020, DOI: 10.7326/0003-4819-127-7-199710010-00004.Peer-Reviewed Original ResearchConceptsPrimary care settingOpioid detoxificationCare settingsBuprenorphine groupWithdrawal symptomsDouble-blind clinical trialOpioid-dependent patientsHeroin-dependent patientsPrimary care clinicsWithdrawal symptom scoresSevere withdrawal symptomsDrug treatment programsSubstance abuse treatmentNaltrexone groupCare clinicsSymptom scoresPharmacologic protocolClinical trialsTreatment protocolClonidineTreatment retentionBuprenorphineNaltrexoneTreatment programAbuse treatment
1994
SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine
van Dyck C, Rosen M, Thomas H, McMahon T, Wallace E, O'Connor P, Sullivan M, Krystal J, Hoffer P, Woods S, Kosten T. SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine. Psychiatry Research 1994, 55: 181-191. PMID: 7701033, DOI: 10.1016/0925-4927(94)90013-2.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowRegional cerebral blood flow alterationsCerebral blood flow alterationsHexamethyl propylene amine oximeOpiate-induced analgesiaBlood flow alterationsSeverity of withdrawalCerebral blood flowOpiate-dependent patientsAnterior cingulate regionsAnterior cingulate cortexSingle photon emissionPlacebo administrationAmine oximeOpiate withdrawalRCBF ratiosWithdrawal severityBlood flowCingulate cortexCingulate regionsSignificant negative correlationBuprenorphineNaltrexonePlaceboPatientsManagement of hospitalized intravenous drug users: Role of the internist
O'Connor P, Samet J, Stein M. Management of hospitalized intravenous drug users: Role of the internist. The American Journal Of Medicine 1994, 96: 551-558. PMID: 8017454, DOI: 10.1016/0002-9343(94)90096-5.Peer-Reviewed Original ResearchMeSH KeywordsDyspneaFemaleFeverHospitalizationHumansInternal MedicineMusculoskeletal DiseasesPain ManagementPatient DischargePhysician's RoleSubstance Abuse, IntravenousSubstance Withdrawal SyndromeConceptsIntravenous drug usersDrug usersHIV statusHospital settingPatient's HIV statusCommon clinical dilemmaHospital discharge planningInpatient hospital settingSignificant clinical challengeCommon behavioral issuesSubstance use problemsDrug withdrawalDischarge planningClinical dilemmaClinical challengeMEDLINE searchMedical problemsInternistsUse problemsBehavioral issuesAppropriate knowledgeRelevant literatureManagementReviewEpidemiology
1992
Ambulatory opiate detoxification and primary care
O’Connor P, Waugh M, Schottenfeld R, Diakogiannis I, Rounsaville B. Ambulatory opiate detoxification and primary care. Journal Of General Internal Medicine 1992, 7: 532-534. PMID: 1403211, DOI: 10.1007/bf02599459.Peer-Reviewed Original Research
1991
Social and clinical features as predictors of outcome in outpatient alcohol withdrawal
O’Connor P, Gottlieb L, Kraus M, Segal S, Horwitz R. Social and clinical features as predictors of outcome in outpatient alcohol withdrawal. Journal Of General Internal Medicine 1991, 6: 312-316. PMID: 1890501, DOI: 10.1007/bf02597427.Peer-Reviewed Original ResearchConceptsWithdrawal symptom severityAlcohol withdrawal syndromeTreatment failureSymptom severityOutpatient managementAlcohol withdrawalClinical featuresWithdrawal syndromeOutpatient alcohol treatment programProspective observational cohort studyHigh-risk patientsObservational cohort studyTreatment failure rateMedical insurance statusPredictors of outcomeAlcohol treatment programsLow symptom groupCohort studyDrug therapyInsurance statusClinical trialsPatient featuresSociodemographic featuresPatientsTreatment program