2012
Counseling and Directly Observed Medication for Primary Care Buprenorphine Maintenance
Moore BA, Barry DT, Sullivan LE, O'Connor PG, Cutter CJ, Schottenfeld RS, Fiellin DA. Counseling and Directly Observed Medication for Primary Care Buprenorphine Maintenance. Journal Of Addiction Medicine 2012, 6: 205-211. PMID: 22614936, PMCID: PMC3419276, DOI: 10.1097/adm.0b013e3182596492.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPhysician managementObserved medicationBaseline characteristicsCBT sessionsOpioid-negative urinesIndividual CBT sessionsBuprenorphine maintenanceOpioid useMedication adherencePatient satisfactionPrimary careImproved outcomesTreatment outcomesSession attendanceNegative urineTreatment groupsGreater abstinenceCounseling intensityDrug useTherapist availabilityMedicationsBuprenorphinePatientsIndependent effects
2006
A Trial of Integrated Buprenorphine/Naloxone and HIV Clinical Care
Sullivan LE, Barry D, Moore BA, Chawarski MC, Tetrault JM, Pantalon MV, O'Connor PG, Schottenfeld RS, Fiellin DA. A Trial of Integrated Buprenorphine/Naloxone and HIV Clinical Care. Clinical Infectious Diseases 2006, 43: s184-s190. PMID: 17109305, DOI: 10.1086/508182.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, SublingualAdultAntiretroviral Therapy, Highly ActiveBuprenorphineDose-Response Relationship, DrugDrug Administration ScheduleFemaleFollow-Up StudiesHIV InfectionsHumansMaleMiddle AgedNaloxoneNarcotic AntagonistsOpioid-Related DisordersPilot ProjectsProbabilityReference ValuesRisk FactorsTreatment OutcomeConceptsHIV clinical careHIV-1 RNA copies/mLBuprenorphine/naloxone treatmentRNA copies/mLCopies/mLOpioid dependenceClinical careOpioid useNaloxone treatmentPhysician managementTreatment retentionHIV type 1 RNA levelsHIV-1 RNA levelsDose of buprenorphinePartial opioid agonistRNA levelsCD4 lymphocyte countBuprenorphine/naloxoneOpioid-dependent patientsUrine toxicology testsWeeks of treatmentHuman immunodeficiency virusUrine test resultsBetter treatment retentionUntreated opioid dependence
2005
Primary Intensive Care: Pilot Study of a Primary CareBased Intervention for High-Utilizing Patients
Brown KE, Levine JM, Fiellin DA, O'connor P, Sledge WH. Primary Intensive Care: Pilot Study of a Primary CareBased Intervention for High-Utilizing Patients. Population Health Management 2005, 8: 169-177. PMID: 15966782, DOI: 10.1089/dis.2005.8.169.Peer-Reviewed Original ResearchConceptsPilot studyHospital cost differencesWeekly multidisciplinary clinicHigher healthcare utilizationPrimary care patientsEmergency department usePrimary care centersPresence of psychopathologyManagement patientsCare patientsHealthcare utilizationMultidisciplinary clinicIntensive careDepartment useCare centerInpatient servicesPatientsPsychiatric diagnosisSpecial interventionStaff satisfactionStatistical significanceInterventionClinicCost differencesDiagnosisDevelopment and Implementation of an Emergency Practitioner–Performed Brief Intervention for Hazardous and Harmful Drinkers in the Emergency Department
D'Onofrio G, Pantalon MV, Degutis LC, Fiellin DA, O'Connor PG. Development and Implementation of an Emergency Practitioner–Performed Brief Intervention for Hazardous and Harmful Drinkers in the Emergency Department. Academic Emergency Medicine 2005, 12: 249-256. PMID: 15741590, PMCID: PMC1414059, DOI: 10.1197/j.aem.2004.10.021.Peer-Reviewed Original ResearchConceptsBrief Negotiation InterviewEmergency practitionersEmergency departmentBrief interventionClinical careEfficacy of BIRoutine clinical careMean durationPatient outcomesHarmful drinkersStandardized patient scenariosClinical practicePatient scenariosDrinkersMean numberInterventionTraining sessionsCarePilot testingDepartmentSessionsHospitalTrials
1997
Sustained-release methylphenidate for cognitive impairment in HIV-1- infected drug abusers: a pilot study
van Dyck CH, McMahon TJ, Rosen MI, O'Malley SS, O'Connor PG, Lin CH, Pearsall HR, Woods SW, Kosten TR. Sustained-release methylphenidate for cognitive impairment in HIV-1- infected drug abusers: a pilot study. Journal Of Neuropsychiatry 1997, 9: 29-36. PMID: 9017526, DOI: 10.1176/jnp.9.1.29.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionCentral Nervous System StimulantsCognition DisordersDelayed-Action PreparationsDouble-Blind MethodFemaleHIV InfectionsHIV-1HumansLearningMaleMemoryMethylphenidateMiddle AgedNeuropsychological TestsOpioid-Related DisordersPilot ProjectsPsychomotor PerformanceSubstance-Related DisordersConceptsSustained-release methylphenidateCognitive impairmentDouble-blind placebo-controlled crossover trialPlacebo-controlled crossover trialComposite neuropsychological measuresImpaired neuropsychological test performanceClinical improvementPlacebo treatmentCrossover trialMethadone patientsNeuropsychological test performancePlacebo performancePsychostimulant drugsDrug abusersPatientsStudy designPilot studySubstance abusersImpairmentNeuropsychological measuresMethylphenidateMore improvementAbusersTreatmentTest performance
1996
A Pilot Study of Primary-Care—Based Buprenorphine Maintenance for Heroin Dependence
O'Connor P, Oliveto A, Shi J, Triffleman E, Carroll K, Kosten T, Rounsaville B. A Pilot Study of Primary-Care—Based Buprenorphine Maintenance for Heroin Dependence. The American Journal Of Drug And Alcohol Abuse 1996, 22: 523-531. PMID: 8911590, DOI: 10.3109/00952999609001678.Peer-Reviewed Original ResearchConceptsPrimary care providersHeroin dependenceBuprenorphine maintenancePilot studyOpioid maintenanceOpen-label pilot studyUrine toxicology dataPrimary care settingDrug treatment settingsSelf-help meetingsPrimary careMajority of urinesTreatment settingsPatientsToxicology dataBuprenorphineTreatmentOpioidsMethadoneProvidersStudySettingDosesMonthsUrine
1995
Primary care-based ambulatory opioid detoxification
O’Connor P, Waugh M, Carroll K, Rounsaville B, Diagkogiannis I, Schottenfeld R. Primary care-based ambulatory opioid detoxification. Journal Of General Internal Medicine 1995, 10: 255-260. PMID: 7616334, DOI: 10.1007/bf02599882.Peer-Reviewed Original ResearchConceptsInjection drug usersClonidine/naltrexoneOpioid detoxificationDrug treatmentProspective nonrandomized clinical trialMedical clinicsPrimary care medical clinicFirst heroin useOngoing drug treatmentNonrandomized clinical trialPrimary care providersWithdrawal symptom scoresSubstance abuse treatmentMuscle crampsSymptom scoresClinical trialsClonidineNurse practitionersCare providersDetoxified patientsHeroin useTreatment groupsNaltrexoneDrug usersMedical units
1992
Ambulatory opiate detoxification and primary care
O’Connor P, Waugh M, Schottenfeld R, Diakogiannis I, Rounsaville B. Ambulatory opiate detoxification and primary care. Journal Of General Internal Medicine 1992, 7: 532-534. PMID: 1403211, DOI: 10.1007/bf02599459.Peer-Reviewed Original Research