2001
Targeting Behavioral Therapies to Enhance Naltrexone Treatment of Opioid Dependence: Efficacy of Contingency Management and Significant Other Involvement
Carroll KM, Ball SA, Nich C, O'Connor PG, Eagan DA, Frankforter TL, Triffleman EG, Shi J, Rounsaville BJ. Targeting Behavioral Therapies to Enhance Naltrexone Treatment of Opioid Dependence: Efficacy of Contingency Management and Significant Other Involvement. JAMA Psychiatry 2001, 58: 755-761. PMID: 11483141, PMCID: PMC3651594, DOI: 10.1001/archpsyc.58.8.755.Peer-Reviewed Original ResearchConceptsDrug-free urine specimensNaltrexone treatmentFamily counseling sessionsContingency managementOpioid dependenceTreatment retentionUrine specimensBehavioral therapyOpioid-dependent individualsCounseling sessionsDrug use outcomesSubstance abuse outcomesNaltrexone complianceNaltrexone therapyOpioid useAvailable pharmacotherapiesMedication complianceSpecific pharmacotherapySignificant improvementTherapyUse outcomesAbuse outcomesPrincipal outcomePharmacotherapyTreatment
2000
Thrice-weekly versus daily buprenorphine maintenance
Schottenfeld R, Pakes J, O’Connor P, Chawarski M, Oliveto A, Kosten T. Thrice-weekly versus daily buprenorphine maintenance. Biological Psychiatry 2000, 47: 1072-1079. PMID: 10862807, DOI: 10.1016/s0006-3223(99)00270-x.Peer-Reviewed Original ResearchConceptsSublingual buprenorphineMaintenance treatmentSelf-reported illicit drug useDrug useOpioid agonist maintenance treatmentOpioid-positive urine testsAgonist maintenance treatmentDaily clinic attendanceDaily sublingual buprenorphineThrice-weekly dosingOpioid-dependent patientsUrine toxicology testsSignificant differencesIllicit drug useSelf-reported numberBuprenorphine maintenanceClinic attendanceWeekly doseIllicit opioidsMedication complianceThrice weeklyUrine testsOutcome measuresBuprenorphineCounseling attendanceNaltrexone-Induced Nausea in Patients Treated for Alcohol Dependence: Clinical Predictors and Evidence for Opioid-Mediated Effects
O'Malley S, Krishnan-Sarin S, Farren C, O'Connor P. Naltrexone-Induced Nausea in Patients Treated for Alcohol Dependence: Clinical Predictors and Evidence for Opioid-Mediated Effects. Journal Of Clinical Psychopharmacology 2000, 20: 69-76. PMID: 10653211, DOI: 10.1097/00004714-200002000-00012.Peer-Reviewed Original ResearchConceptsRisk of nauseaEndogenous opioid systemIntensity of drinkingSevere nauseaOpioid systemAlcohol useLight drinkersMost alcoholic patientsWeeks of naltrexoneOpen-label trialLong-term alcohol usePoor medication compliancePretreatment patient characteristicsLogistic regression analysisAlcohol-dependent subjectsDays of abstinenceDuration of abstinenceSignificant nauseaPatient characteristicsClinical predictorsEndogenous opioidsMedication complianceAlcoholic patientsNaltrexone doseRisk factors
1999
Measurement of compliance with naltrexone in the treatment of alcohol dependence: research and clinical implications.
Namkoong K, Farren CK, O'Connor PG, O'Malley SS. Measurement of compliance with naltrexone in the treatment of alcohol dependence: research and clinical implications. The Journal Of Clinical Psychiatry 1999, 60: 449-53. PMID: 10453799, DOI: 10.4088/jcp.v60n0706.Peer-Reviewed Original ResearchConceptsMedication Event Monitoring SystemMedication compliancePill countAlcohol dependenceOpen-label studyPill-taking behaviorSample of patientsEvent Monitoring SystemMeasurement of complianceEstimates of complianceCompliant groupPharmacotherapy researchTreatment outcomesClinical utilityCompliance rateNaltrexoneClinical implicationsOverall outcomeDrinking outcomesPatientsMEMS dataOutcomesCountTreatmentCompliance