2020
Redefining the Role of Surgical Management of Metastatic Renal Cell Carcinoma
Hsiang WR, Kenney PA, Leapman MS. Redefining the Role of Surgical Management of Metastatic Renal Cell Carcinoma. Current Oncology Reports 2020, 22: 35. PMID: 32170461, DOI: 10.1007/s11912-020-0895-y.Peer-Reviewed Original ResearchConceptsMetastatic renal cell carcinomaSystemic therapyRenal cell carcinomaCytoreductive nephrectomySurgical therapyCell carcinomaManagement of mRCCPoor-risk metastatic renal cell carcinomaInitial systemic therapyReviewThe treatment landscapeTargeted therapy eraUpfront cytoreductive nephrectomyViable treatment approachSequence of surgeryTherapy eraTreatment landscapeUnselected patientsSurgical managementSummaryRecent evidenceRecent FindingsOneTreatment approachesNephrectomyTherapyOptimal rolePatients
2019
Unified Approaches to Surgery and Systemic Therapy for Renal Cell Carcinoma
Abello A, Kenney P. Unified Approaches to Surgery and Systemic Therapy for Renal Cell Carcinoma. 2019, 411-435. DOI: 10.1007/978-3-030-24378-4_24.Peer-Reviewed Original ResearchRenal cell carcinomaSystemic therapyCell carcinomaMetastatic renal cell carcinomaDisease-free survivalHigh-risk subsetVenous tumor thrombusTyrosine kinase inhibitorsAdjuvant settingCytoreductive nephrectomyUnresectable diseaseAdjuvant therapyAdvanced diseaseNeoadjuvant therapyOverall survivalTumor thrombusGenitourinary malignanciesPartial nephrectomySignificant causeTherapyEffective agentNephrectomyMonoclonal antibodiesKinase inhibitorsDisease
2013
Preoperative Pulmonary Embolism Does Not Predict Poor Postoperative Outcomes in Patients with Renal Cell Carcinoma and Venous Thrombus
Abel EJ, Wood CG, Eickstaedt N, Fang JE, Kenney P, Bagrodia A, Youssef RF, Sagalowsky AI, Margulis V. Preoperative Pulmonary Embolism Does Not Predict Poor Postoperative Outcomes in Patients with Renal Cell Carcinoma and Venous Thrombus. Journal Of Urology 2013, 190: 452-457. PMID: 23434945, DOI: 10.1016/j.juro.2013.02.033.Peer-Reviewed Original ResearchConceptsPreoperative pulmonary embolismCancer-specific survivalRenal cell carcinomaPulmonary embolismPoor postoperative outcomesCell carcinomaSpecific survivalVenous thrombiPostoperative outcomesMetastatic renal cell carcinomaCox proportional hazards analysisWorse cancer-specific survivalConsecutive patient recordsHigh-level thrombusProportional hazards analysisHigher T stagePostoperative disease recurrencePerioperative mortalityMedian followupDisease recurrenceTumor thrombusT stageTertiary hospitalEarly mortalityMulticenter study
2012
Integration of Surgery and Systemic Therapy for Renal Cell Carcinoma
Kenney PA, Wood CG. Integration of Surgery and Systemic Therapy for Renal Cell Carcinoma. Urologic Clinics Of North America 2012, 39: 211-231. PMID: 22487764, DOI: 10.1016/j.ucl.2012.01.005.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Agents, HormonalCarcinoma, Renal CellChemotherapy, AdjuvantCombined Modality TherapyFemaleHumansImmunotherapyKidney NeoplasmsMaleNeoadjuvant TherapyNeoplasm InvasivenessNeoplasm StagingNephrectomyPrognosisRadiotherapy, AdjuvantRisk AssessmentSurvival AnalysisTreatment OutcomeConceptsRenal cell carcinomaSystemic therapyCell carcinomaMetastatic renal cell carcinomaAdvanced nonmetastatic diseaseUpfront cytoreductive nephrectomyIntegration of surgeryCytoreductive nephrectomyCytoreductive surgeryNeoadjuvant therapyNonmetastatic diseaseAdjuvant therapyMetastatic diseaseAppropriate patientsTherapySurgeryDiseaseCurrent roleNephrectomyFurther studiesCarcinomaPotential benefitsPatientsTrialsNodal disease in the setting of metastatic renal cell carcionoma: Can a lymph node dissection alter outcomes?
Chapin B, Delacroix S, Kenney P, Nogueras Gonzalez G, Tamboli P, Jonasch E, Tannir N, Wood C. Nodal disease in the setting of metastatic renal cell carcionoma: Can a lymph node dissection alter outcomes? Journal Of Clinical Oncology 2012, 30: 386-386. DOI: 10.1200/jco.2012.30.5_suppl.386.Peer-Reviewed Original ResearchLymph node dissectionMetastatic renal cell carcinomaCytoreductive nephrectomyOverall survivalCN0 patientsNodal diseasePN0 patientsWorse OSCox proportional hazards regressionClinical node statusTargeted therapy eraMedian overall survivalPost-operative complicationsWorse median OSProportional hazards regressionRenal cell carcinomaLong-axis diameterImproved OSMedian OSTherapy eraNode dissectionClavien systemLN statusPositive diseaseComplete resection