2011
Partial Exchange Transfusion for Polycythemia Hyperviscosity Syndrome
Hopewell B, Steiner L, Ehrenkranz R, Bizzarro M, Gallagher P. Partial Exchange Transfusion for Polycythemia Hyperviscosity Syndrome. American Journal Of Perinatology 2011, 28: 557-564. PMID: 21365533, DOI: 10.1055/s-0031-1274504.Peer-Reviewed Original ResearchConceptsPartial exchange transfusionPercent of patientsRisk factorsMaternal diabetesExchange transfusionSignificant complicationsHyperviscosity syndromeNeonatal intensive care unitYale-New Haven HospitalLife-threatening complicationsLong-term followIntensive care unitNeonatal medical recordsPatient demographicsRetrospective reviewCare unitMedical recordsRisk populationsComplicationsPatientsStudy periodSignificant decreaseTransfusionDiabetesSyndrome
2004
Mutation of a highly conserved isoleucine disrupts hydrophobic interactions in the αβ spectrin self-association binding site
Gallagher PG, Zhang Z, Morrow JS, Forget BG. Mutation of a highly conserved isoleucine disrupts hydrophobic interactions in the αβ spectrin self-association binding site. Laboratory Investigation 2004, 84: 229-234. PMID: 14661034, DOI: 10.1038/labinvest.3700029.Peer-Reviewed Original ResearchConceptsBinding sitesAlpha-spectrin mutationsEvolutionary conservationSpectrin functionSpectrin repeatsTriple helical modelAlpha-spectrinGenetic studiesHydrophobic isoleucineHydrophobic interactionsLow-expression alleleMolecular modelingExpression alleleSpectrinFunctional defectsTriple helixMutationsHelical modelIsoleucineErythrocyte membranesDrosophilaClinical phenotypeNeonatal hemolytic anemiaRepeatsHelix