2015
Clinical and Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Neonatal Intensive Care Unit in the Decade following Implementation of an Active Detection and Isolation Program
Nelson MU, Bizzarro MJ, Baltimore RS, Dembry LM, Gallagher PG. Clinical and Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Neonatal Intensive Care Unit in the Decade following Implementation of an Active Detection and Isolation Program. Journal Of Clinical Microbiology 2015, 53: 2492-2501. PMID: 26019206, PMCID: PMC4508396, DOI: 10.1128/jcm.00470-15.Peer-Reviewed Original ResearchMeSH KeywordsDNA, BacterialEpidemiological MonitoringFemaleGenetic VariationGenotypeGenotyping TechniquesHumansInfantInfant, NewbornIntensive Care Units, NeonatalMaleMethicillin-Resistant Staphylococcus aureusMolecular EpidemiologyMolecular TypingRetrospective StudiesStaphylococcal InfectionsVirulence FactorsConceptsNeonatal intensive care unitMethicillin-resistant Staphylococcus aureusIntensive care unitMRSA colonizationMolecular epidemiologyCare unitStaphylococcal cassette chromosome mec type IIAccessory gene regulator (agr) groupsMRSA colonization rateToxic shock syndrome toxinAgr group 1Exfoliative toxin AStaphylococcus aureusPotential virulence factor genesVirulence factor genesMRSA infectionSignificant morbidityClinical differencesPatient daysPulsed-field gel electrophoresisToxin AUSA300 strainGroup 1Continued vigilanceInfection
2014
One size does not fit all: why universal decolonization strategies to prevent methicillin-resistant Staphylococcus aureus colonization and infection in adult intensive care units may be inappropriate for neonatal intensive care units
Nelson MU, Bizzarro MJ, Dembry LM, Baltimore RS, Gallagher PG. One size does not fit all: why universal decolonization strategies to prevent methicillin-resistant Staphylococcus aureus colonization and infection in adult intensive care units may be inappropriate for neonatal intensive care units. Journal Of Perinatology 2014, 34: 653-655. PMID: 25010223, PMCID: PMC4152419, DOI: 10.1038/jp.2014.125.Peer-Reviewed Original ResearchMeSH KeywordsAdultChlorhexidineHumansInfant, NewbornInfant, Premature, DiseasesIntensive Care UnitsIntensive Care Units, NeonatalMethicillin-Resistant Staphylococcus aureusMupirocinStaphylococcal InfectionsConceptsNeonatal intensive care unitIntensive care unitAdult intensive care unitsCare unitUniversal decolonizationMethicillin-resistant Staphylococcus aureus (MRSA) colonizationMRSA-positive clinical cultureUnique patient populationLarge multicenter trialsStaphylococcus aureus colonizationLong-term safetyMupirocin applicationAdverse eventsPreterm infantsLarge multicenterMulticenter trialPatient populationAureus colonizationDecolonization strategiesClinical culturesDisease controlHealthcare ResearchTrialsTrial methodsWidespread implementation
2012
Methicillin-Resistant Staphylococcus aureus in the Neonatal Intensive Care Unit
Nelson MU, Gallagher PG. Methicillin-Resistant Staphylococcus aureus in the Neonatal Intensive Care Unit. Seminars In Perinatology 2012, 36: 424-430. PMID: 23177801, PMCID: PMC3508470, DOI: 10.1053/j.semperi.2012.06.004.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBacterial Physiological PhenomenaClinical ProtocolsCommunity-Acquired InfectionsCost of IllnessCross InfectionHumansInfant, NewbornInfant, PrematureInfant, Premature, DiseasesInfection ControlIntensive Care Units, NeonatalMethicillin-Resistant Staphylococcus aureusPrevalenceRisk FactorsStaphylococcal InfectionsConceptsNeonatal intensive care unitMethicillin-resistant Staphylococcus aureusIntensive care unitCare unitCharacteristics of MRSAStaphylococcus aureusCertain infantsMRSA infectionNICU populationIll infantsRisk factorsEpidemiologic assessmentClinical interventionsInfectionFrequent sourceInfantsTransmission patternsInterventionAureusMolecular analysisAdditional factorsMorbidityNeonatesNumerous strategiesPrevention