2022
HMGB1-mediated restriction of EPO signaling contributes to anemia of inflammation
Dulmovits BM, Tang Y, Papoin J, He M, Li J, Yang H, Addorisio ME, Kennedy L, Khan M, Brindley E, Ashley RJ, Ackert-Bicknell C, Hale J, Kurita R, Nakamura Y, Diamond B, Barnes BJ, Hermine O, Gallagher PG, Steiner LA, Lipton JM, Taylor N, Mohandas N, Andersson U, Al-Abed Y, Tracey KJ, Blanc L. HMGB1-mediated restriction of EPO signaling contributes to anemia of inflammation. Blood 2022, 139: 3181-3193. PMID: 35040907, PMCID: PMC9136881, DOI: 10.1182/blood.2021012048.Peer-Reviewed Original ResearchConceptsAnemia of inflammationDamage-associated molecular pattern moleculesHigh-mobility group box 1 proteinMobility group box 1 proteinErythroid precursorsGroup box 1 proteinAdvanced glycation end productsAnti-HMGB1 antibodyGlycation end productsMolecular pattern moleculesChronic phaseSepsis onsetChronic diseasesHMGB1 receptorsAnemia developmentPattern moleculesAnemiaGenetic ablationInflammationMurine precursorRefractory stateHMGB1Reduced expansionEPO signalingDeleterious effects
2015
Neonatal Sepsis 2004-2013: The Rise and Fall of Coagulase-Negative Staphylococci
Bizzarro MJ, Shabanova V, Baltimore RS, Dembry LM, Ehrenkranz RA, Gallagher PG. Neonatal Sepsis 2004-2013: The Rise and Fall of Coagulase-Negative Staphylococci. The Journal Of Pediatrics 2015, 166: 1193-1199. PMID: 25919728, PMCID: PMC4413005, DOI: 10.1016/j.jpeds.2015.02.009.Peer-Reviewed Original ResearchConceptsEarly-onset sepsisLate-onset sepsisNeonatal intensive care unitCoagulase-negative staphylococciIntensive care unitCare unitLevel IV neonatal intensive care unitEpisodes of sepsisLow birth weightInfection prevention initiativesInfection prevention effortsPercent of casesGroup B streptococciHospital courseSepsis episodesMost infantsBirth weightCommon organismB streptococciSepsisOutcome dataAdditional surveillancePrevention effortsStudy periodInfants
2014
Clinical and Laboratory Factors That Predict Death in Very Low Birth Weight Infants Presenting With Late-onset Sepsis
Levit O, Bhandari V, Li FY, Shabanova V, Gallagher PG, Bizzarro MJ. Clinical and Laboratory Factors That Predict Death in Very Low Birth Weight Infants Presenting With Late-onset Sepsis. The Pediatric Infectious Disease Journal 2014, 33: 143-146. PMID: 24418836, PMCID: PMC3917323, DOI: 10.1097/inf.0000000000000024.Peer-Reviewed Original ResearchConceptsLate-onset sepsisLow birth weight infantsBirth weight infantsIndependent risk factorLaboratory factorsWeight infantsVLBW infantsRisk factorsCases of LOSEpisodes of LOSRisk of LOSFungal LOSNeonatal intensive care unitMultivariate logistic regression analysisSepsis-related deathsIntensive care unitOnset of illnessSepsis-associated mortalityGram-positive infectionsLogistic regression analysisOnset of diseasePresentation of illnessComposite risk profileLaboratory signsNecrotizing enterocolitis
2011
Granulicatella adiacens and Early-Onset Sepsis in Neonate - Volume 17, Number 10—October 2011 - Emerging Infectious Diseases journal - CDC
Bizzarro MJ, Callan DA, Farrel PA, Dembry LM, Gallagher PG. Granulicatella adiacens and Early-Onset Sepsis in Neonate - Volume 17, Number 10—October 2011 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2011, 17: 1971-1973. PMID: 22000391, PMCID: PMC3310662, DOI: 10.3201/eid1710.101967.Peer-Reviewed Original Research
2005
Seventy-Five Years of Neonatal Sepsis at Yale: 1928–2003
Bizzarro MJ, Raskind C, Baltimore RS, Gallagher PG. Seventy-Five Years of Neonatal Sepsis at Yale: 1928–2003. Pediatrics 2005, 116: 595-602. PMID: 16140698, DOI: 10.1542/peds.2005-0552.Peer-Reviewed Original ResearchConceptsYale-New Haven HospitalEpisodes of sepsisLate-onset sepsisRecords of infantsPositive blood culturesNeonatal sepsisPreterm infantsBlood culturesSepsis-related mortality rateEarly-onset sepsisProlonged mechanical ventilationCentral vascular catheterNeonatal sepsis casesPopulation of infantsGroup B streptococciPercentage of casesDays of ageParenteral nutritionSepsis casesMechanical ventilationVascular cathetersIntensive careS pyogenesB streptococciSepsis