2011
Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo
Isern J, He Z, Fraser ST, Nowotschin S, Ferrer-Vaquer A, Moore R, Hadjantonakis AK, Schulz V, Tuck D, Gallagher PG, Baron MH. Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo. Blood 2011, 117: 4924-4934. PMID: 21263157, PMCID: PMC3100699, DOI: 10.1182/blood-2010-10-313676.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCell LineageCytokinesDNA PrimersEpsilon-GlobinsErythroid Precursor CellsErythropoiesisFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalGene Regulatory NetworksGlycolysisGreen Fluorescent ProteinsGrowth SubstancesMaleMiceMice, Inbred ICRMice, TransgenicOxygenPregnancyRecombinant Fusion ProteinsRNA, MessengerSignal TransductionConceptsPrimitive erythroid progenitorsMouse embryosErythroid progenitorsGlobal expression profilesEmbryonic day 7.5Critical regulatory factorKey regulatory pathwaysOnset of circulationFirst transcriptomeRemarkable proliferative capacityTranscript diversityTransgenic reporterTranscriptome analysisFirst cell typeRegulatory pathwaysHematopoietic lineagesExpression profilesRegulatory factorsCell typesDay 7.5EmbryosProgenitorsYolk sacBlood progenitorsGlycolytic profile
2010
Determinants of erythrocyte hydration
Rinehart J, Gulcicek EE, Joiner CH, Lifton RP, Gallagher PG. Determinants of erythrocyte hydration. Current Opinion In Hematology 2010, 17: 191-197. PMID: 20182354, PMCID: PMC4155397, DOI: 10.1097/moh.0b013e32833800d0.Peer-Reviewed Original ResearchMeSH KeywordsAnemia, Sickle CellAnimalsBody WaterErythrocytesHomeostasisHumansSignal TransductionWater-Electrolyte BalanceConceptsSickle cell diseaseErythrocyte hydrationCell diseaseNew therapeutic targetsGardos channel activationClinical complicationsPrimary disorderSecondary disordersTherapeutic targetErythrocyte dehydrationDisease preventionRelated disordersSolute homeostasisBiologic studiesDisordersChannel activationKCl cotransportDiseaseErythrocyte waterHomeostasisErythrocytesAnion transportersPremature destructionRecent studiesComplications