2012
MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation
Smith EC, Thon JN, Devine MT, Lin S, Schulz VP, Guo Y, Massaro SA, Halene S, Gallagher P, Italiano JE, Krause DS. MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation. Blood 2012, 120: 2317-2329. PMID: 22806889, PMCID: PMC3447785, DOI: 10.1182/blood-2012-04-420828.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine DiphosphateAnimalsBleeding TimeBlood PlateletsBone Marrow CellsCells, CulturedCrosses, GeneticCytoplasmCytoskeletonGene Expression ProfilingHematopoiesisMegakaryocytesMiceMice, Inbred C57BLMice, KnockoutOligonucleotide Array Sequence AnalysisPlatelet ActivationThrombocytopeniaTrans-ActivatorsTranscription FactorsConceptsMegakaryocyte maturationPlatelet formationSerum response factorSerum response factor expressionMembrane organizationGene expressionMKL1MKL2Response factorDKO miceKO backgroundMegakaryocyte compartmentMegakaryocytesCritical roleMegakaryocyte ploidyExpressionMaturationKnockout miceFactor expressionCrucial roleHomologuesGenesMiceProlonged bleeding timeRole
2007
A Decline in the Frequency of Neonatal Exchange Transfusions and Its Effect on Exchange-Related Morbidity and Mortality
Steiner LA, Bizzarro MJ, Ehrenkranz RA, Gallagher PG. A Decline in the Frequency of Neonatal Exchange Transfusions and Its Effect on Exchange-Related Morbidity and Mortality. Pediatrics 2007, 120: 27-32. PMID: 17606558, DOI: 10.1542/peds.2006-2910.Peer-Reviewed Original ResearchMeSH KeywordsExchange Transfusion, Whole BloodFemaleHumansHyperbilirubinemia, NeonatalHypocalcemiaInfant, NewbornMaleThrombocytopeniaConceptsExchange transfusionNeonatal exchange transfusionPatient demographicsDouble volume exchange transfusionSpecial care unit admissionsCare unit admissionRetrospective chart reviewSerious underlying conditionsUnit admissionIntravenous immunoglobulinAdverse eventsChart reviewCalcium replacementHigher proportionPlatelet transfusionsPostnatal careSingle institutionUnderlying conditionTransfusionPatientsClinical practiceAmerican AcademyUniform protocolSame time periodManagement guidelines