2011
Primitive Erythroid Progenitors Are Regulated by Hypoxia and Display An Aerobic Glycolytic Metabolic Profile,
Baron M, Isern J, Fraser S, He Z, Ma'ayan A, Schulz V, Tuck D, Gallagher P. Primitive Erythroid Progenitors Are Regulated by Hypoxia and Display An Aerobic Glycolytic Metabolic Profile,. Blood 2011, 118: 3159. DOI: 10.1182/blood.v118.21.3159.3159.Peer-Reviewed Original ResearchErythroid developmentGenome-wide expression profilingErythroid cell fateCandidate transcriptional regulatorsCell typesHIF-1Transcription factor HIF-1Early mouse embryosMouse yolk sacNumber of genesHIF-1 target genesMost mammalian cellsAnalysis of promotersYolk sacDominant negative regulatorGlycolytic metabolic profileStem/progenitorsPrimitive erythropoiesisPrimitive erythroid progenitorsMesodermal progenitorsCell fateTranscriptional regulatorsTranscription profilingMammalian embryosKinase network
2007
Novel role for EKLF in megakaryocyte lineage commitment
Frontelo P, Manwani D, Galdass M, Karsunky H, Lohmann F, Gallagher PG, Bieker JJ. Novel role for EKLF in megakaryocyte lineage commitment. Blood 2007, 110: 3871-3880. PMID: 17715392, PMCID: PMC2190608, DOI: 10.1182/blood-2007-03-082065.Peer-Reviewed Original ResearchConceptsErythroid gene regulationKrüppel-like factorMegakaryocyte-erythroid progenitorsFormation of megakaryocytesGene regulationTranscriptional regulatorsLineage commitmentTranscription factorsHematopoietic differentiationErythroid differentiationCommon progenitorExpression profilingErythroid cellsEKLFMegakaryocyte lineageNovel roleMolecular analysisLineagesMessage levelsFunction studiesMegakaryocytesProgenitorsDifferentiationRepressionGenes
2006
Novel Role for EKLF in Megakaryocyte-Erythroid Differential Lineage Commitment.
Frontelo M, Manwani D, Galdass M, Karsunky H, Gallagher P, Bieker J. Novel Role for EKLF in Megakaryocyte-Erythroid Differential Lineage Commitment. Blood 2006, 108: 4205. DOI: 10.1182/blood.v108.11.4205.4205.Peer-Reviewed Original ResearchEKLF expressionLineage decisionsLineage commitmentErythroid gene regulationMolecular analysisFormation of megakaryocytesGene regulationTranscriptional regulatorsUnexpected functionTranscription factorsErythroid differentiationCommon progenitorExpression profilingErythroid cellsEKLFNovel rolePrecursor cellsCell compartmentMessage levelsFunction studiesMegakaryocytesRed cell compartmentCrucial roleExpressionCells