USF1 and hSET1A Mediated Epigenetic Modifications Regulate Lineage Differentiation and HoxB4 Transcription
Deng C, Li Y, Liang S, Cui K, Salz T, Yang H, Tang Z, Gallagher PG, Qiu Y, Roeder R, Zhao K, Bungert J, Huang S. USF1 and hSET1A Mediated Epigenetic Modifications Regulate Lineage Differentiation and HoxB4 Transcription. PLOS Genetics 2013, 9: e1003524. PMID: 23754954, PMCID: PMC3675019, DOI: 10.1371/journal.pgen.1003524.Peer-Reviewed Original ResearchMeSH KeywordsBasic Helix-Loop-Helix Transcription FactorsCell DifferentiationCell LineageEmbryonic Stem CellsEpigenesis, GeneticGene Expression RegulationHistone-Lysine N-MethyltransferaseHomeodomain ProteinsHumansK562 CellsMesodermMethyltransferasesProto-Oncogene ProteinsT-Cell Acute Lymphocytic Leukemia Protein 1Transcription FactorsTranscriptional ActivationUpstream Stimulatory FactorsConceptsEmbryonic stem cellsLineage differentiationTrithorax complexesHoxb4 genesMethyltransferase complexTranscription preinitiation complex assemblyHistone H3K4 methyltransferase complexRNA interference-mediated knockdownBivalent chromatin domainsH3K4 methyltransferase complexUndifferentiated embryonic stem cellsPreinitiation complex assemblyHistone methyltransferase complexTranscription factor USF1H3K4 methyltransferase activityHematopoietic stem/progenitor cellsHematopoietic cell populationsStem/progenitor cellsDPY-30HOXB4 promoterMesoderm specificationChromatin domainsMesoderm differentiationH3K4me3 modificationHematopoietic transition