The Histone Methyltransferase Setd8 Is Essential for Mammalian Erythropoiesis
Malik J, Getman M, Lillis J, Gallagher P, Steiner L. The Histone Methyltransferase Setd8 Is Essential for Mammalian Erythropoiesis. Blood 2015, 126: 3577. DOI: 10.1182/blood.v126.23.3577.3577.Peer-Reviewed Original ResearchCell cycle progressionNuclear condensationTranscriptional regulationMammalian erythropoiesisErythroid maturationGATA2 expressionErythroid cellsCycle progressionHistone H4 lysine 20Sole histone methyltransferaseGFP fusion proteinH4 lysine 20Histone methyltransferase Setd8Erythroid transcription factorsErythroid-specific genesEarly embryonic lethalityGlobal transcriptome analysisDNA damage responseMajority of transcriptsRNA-seq analysisCell cycle checkpointsKey regulatory regionsCommitted erythroid progenitorsErythro-myeloid progenitorsPrimary human erythroblasts