2010
Low urinary citrate: an overview.
Zacchia M, Preisig P. Low urinary citrate: an overview. Journal Of Nephrology 2010, 23 Suppl 16: s49-56. PMID: 21170889.Peer-Reviewed Original ResearchConceptsUrinary citrate excretionCitrate excretionStone formationCalcium stone formationProximal tubule cellsAcid-base statusKidney stone formationRisk factorsFiltered loadImportant physiological determinantGlomerular filtrateTubule cellsAcid loadExcretionAlkaline loadCitrate levelsHypocitraturiaMetabolic processesMitochondrial metabolic processesPhysiological determinantsMetabolismMitochondrial metabolismCitrate metabolismNaDC1
2007
The acid-activated signaling pathway: Starting with Pyk2 and ending with increased NHE3 activity
Preisig PA. The acid-activated signaling pathway: Starting with Pyk2 and ending with increased NHE3 activity. Kidney International 2007, 72: 1324-1329. PMID: 17882150, DOI: 10.1038/sj.ki.5002543.Peer-Reviewed Original ResearchConceptsTypical Western dietSystemic acid-base balanceMultiple nephron segmentsProximal tubule cellsAcid-base balanceNa/H antiporterWestern dietBicarbonate reclamationProximal tubulesTubule cellsNephron segmentsAcid loadAmmonium secretionLuminal protonsNHE3 activityH antiporterSecretionNHE3Titratable acid
2006
Dual role of citrate in mammalian urine
Moe OW, Preisig PA. Dual role of citrate in mammalian urine. Current Opinion In Nephrology & Hypertension 2006, 15: 419-424. PMID: 16775456, DOI: 10.1097/01.mnh.0000232882.35469.72.Peer-Reviewed Original Research
2005
Hypothesizing on the evolutionary origins of salt-induced hypercalciuria
Moe OW, Preisig PA. Hypothesizing on the evolutionary origins of salt-induced hypercalciuria. Current Opinion In Nephrology & Hypertension 2005, 14: 368-372. PMID: 15931006, DOI: 10.1097/01.mnh.0000172724.29628.73.Peer-Reviewed Original Research
2004
A consensus sequence in the endothelin-B receptor second intracellular loop is required for NHE3 activation by endothelin-1
Laghmani K, Sakamoto A, Yanagisawa M, Preisig PA, Alpern RJ. A consensus sequence in the endothelin-B receptor second intracellular loop is required for NHE3 activation by endothelin-1. American Journal Of Physiology. Renal Physiology 2004, 288: f732-f739. PMID: 15598844, DOI: 10.1152/ajprenal.00300.2004.Peer-Reviewed Original ResearchConceptsEndothelin-1Second intracellular loopET-1 stimulationNHE3 activityIntracellular loopEndothelin-A receptorAdenylyl cyclase inhibitionET-1 regulationProximal tubule apical membraneET receptorsCyclase inhibitionOKP cellsNHE3 activationOpossum kidneyExchanger 3ReceptorsStimulationProtein tyrosine phosphorylationReceptor chimerasPresent studyCellsAdditional mechanismTyrosine phosphorylationApical membraneSimilar pattern
2000
A better understanding of the kidney in health and disease: what will it take?
Moe O, Preisig P. A better understanding of the kidney in health and disease: what will it take? Current Opinion In Nephrology & Hypertension 2000, 9: 381-384. PMID: 10926174, DOI: 10.1097/00041552-200007000-00009.Peer-Reviewed Original Research
1999
A cell cycle-dependent mechanism of renal tubule epithelial cell hypertrophy
Preisig P. A cell cycle-dependent mechanism of renal tubule epithelial cell hypertrophy. Kidney International 1999, 56: 1193-1198. PMID: 10610409, DOI: 10.1046/j.1523-1755.1999.00708.x.Peer-Reviewed Original ResearchWhat Makes Cells Grow Larger and How Do They Do It? Renal Hypertrophy Revisited
Preisig P. What Makes Cells Grow Larger and How Do They Do It? Renal Hypertrophy Revisited. Nephron 1999, 7: 273-283. PMID: 10450014, DOI: 10.1159/000020614.Peer-Reviewed Original ResearchConceptsCell cycle-dependent mechanismCell cycle-independent mechanismsCell cycle processRegulation of processesRenal hypertrophyProtein degradationChronic potassium deficiencyCompensatory renal growthChronic metabolic acidosisDevelopment of hypertrophyCompensatory renal hypertrophyPotassium deficiencyDiabetes mellitusMetabolic acidosisLysosomal enzymesRenal growthCell sizeHypertrophyCell numberInitial eventProtein feedingRegulationVivo studiesCell culture studiesCycle process
1998
Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemia
Melnick J, Preisig P, Haynes S, Pak C, Sakhaee K, Alpern R. Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemia. Kidney International 1998, 54: 1670-1674. PMID: 9844143, DOI: 10.1046/j.1523-1755.1998.00150.x.Peer-Reviewed Original ResearchConceptsUrinary citrate excretionCitrate excretionUrinary citrateMetabolic acidosisATP-citrate lyaseEffects of enalaprilRenal citrate metabolismUrine citrate concentrationRenal cortical tissueChronic metabolic acidosisProximal tubular cellsPlasma pHNa/H antiporterAngiotensin IIIntracellular acidosisEnalaprilTubular cellsCitrate lyaseHypokalemiaEnzyme inhibitorsATP citrate lyase activityAcidosisCortical tissueRatsCitrate metabolismDevelopment of a Patient Classification System for Chronic Hemodialysis Patients
Freund L, Burrows-Hudson S, Preisig P. Development of a Patient Classification System for Chronic Hemodialysis Patients. American Journal Of Kidney Diseases 1998, 31: 818-829. PMID: 9590192, DOI: 10.1016/s0272-6386(98)70051-4.Commentaries, Editorials and LettersConceptsAmerican Nephrology Nurses' AssociationChronic hemodialysis patientsPatient classification systemHemodialysis patientsCaregiver timeIndependent factorsTreatment sessionsAcuity toolDialysis treatment sessionsLevel I patientsPatient acuity toolI patientsPatient acuityPatientsTreatment dataNurses AssociationClassification systemOverall average timeExpert panelDifferent centersIndividual treatmentTreatment effectsAverage timeStrongest predictorAcuity
1996
NH4Cl-induced hypertrophy is mediated by weak base effects and is independent of cell cycle processes
Franch H, Preisig P. NH4Cl-induced hypertrophy is mediated by weak base effects and is independent of cell cycle processes. American Journal Of Physiology 1996, 270: c932-c938. PMID: 8638677, DOI: 10.1152/ajpcell.1996.270.3.c932.Peer-Reviewed Original ResearchConceptsC-fos mRNA abundanceHuman papilloma virus 16NRK-52E cellsWeak base propertiesCell cycle processRenal hypertrophyClinical conditionsVirus 16Renal epithelial cellsCultured renal epithelial cellsCell cycleHypertrophyE7 genesAdditional studiesEpithelial cellsVesicular alkalinizationMRNA abundancePresent studyInactivation of pRbCellsProtein synthesisVacuolar proton pumpProtein abundanceVesicular compartments
1995
Chronic regulation of the proximal tubular Na/H antiporter: From HCO3 to SRC
Alpern R, Moe O, Preisig P. Chronic regulation of the proximal tubular Na/H antiporter: From HCO3 to SRC. Kidney International 1995, 48: 1386-1396. PMID: 8544394, DOI: 10.1038/ki.1995.427.Peer-Reviewed Original ResearchConceptsNa/H antiporterChronic regulationH secretionProximal tubulesH antiporterNaCl absorptionProximal tubular acidificationMajor siteNa/K pumpCitrate reabsorptionBasolateral membraneTubular acidificationAcute regulationLuminal membraneK pumpExcretionReabsorptionSecretionPivotal roleVacuolar H-ATPaseH-ATPaseTubulesInvolvement of pRB family in TGF beta-dependent epithelial cell hypertrophy.
Franch HA, Shay JW, Alpern RJ, Preisig PA. Involvement of pRB family in TGF beta-dependent epithelial cell hypertrophy. Journal Of Cell Biology 1995, 129: 245-254. PMID: 7698989, PMCID: PMC2120382, DOI: 10.1083/jcb.129.1.245.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, Polyomavirus TransformingBlotting, NorthernCell CycleCell DivisionCell LineCells, CulturedEpidermal Growth FactorEpithelial CellsEpitheliumGene ExpressionHumansHypertrophyKidneyKidney TubulesKineticsOncogene Proteins, ViralPapillomavirus E7 ProteinsPhosphorylationProto-Oncogene Proteins c-fosRabbitsRatsRecombinant ProteinsRepressor ProteinsRetinoblastoma ProteinRNA, MessengerTransfectionTransforming Growth Factor betaTumor Suppressor Protein p53ConceptsEpithelial cell hypertrophyNRK-52E cellsCell hypertrophyHPV16 E6TGF betaSV40 large T antigenC-fos mRNA abundanceGrowth factor beta 1SV40 large T antigen expressionLarge T antigenLarge T antigen expressionMechanisms of hypertrophyRenal cell hypertrophyRabbit proximal tubuleActive pRbT-antigen expressionRenal functionT antigenRenal hypertrophyAntigen expressionEpidermal growth factorEGF-induced increaseProximal tubulesHypertrophyHPV16 E7
1991
Basolateral membrane H/HCO3 transport in renal tubules
Preisig P, Alpern R. Basolateral membrane H/HCO3 transport in renal tubules. Kidney International 1991, 39: 1077-1086. PMID: 1895662, DOI: 10.1038/ki.1991.137.Peer-Reviewed Original ResearchConceptsCell exitRegulation of proximal reabsorption by effective arterial blood volume.
Seldin DW, Preisig PA, Alpern RJ. Regulation of proximal reabsorption by effective arterial blood volume. Seminars In Nephrology 1991, 11: 212-9. PMID: 2034926.Peer-Reviewed Original ResearchConceptsEffective arterial blood volumeEffective arterial volumeRenal nerve activityProximal tubular transportAtrial natriuretic factorArterial blood volumeLevels of hormonesRenal hemodynamicsNerve activityDietary NaClAngiotensin IIProximal reabsorptionNatriuretic factorBlood volumeTubular transportProximal tubulesChronic effectsArterial volumeOncotic pressureNorepinephrineHemodynamicsEpinephrineHormoneReabsorption
1990
Cellular model of proximal tubule NaCl and NaHCO3 absorption
Moe O, Preisig P, Alpern R. Cellular model of proximal tubule NaCl and NaHCO3 absorption. Kidney International 1990, 38: 605-611. PMID: 2172616, DOI: 10.1038/ki.1990.249.Peer-Reviewed Original ResearchBasolateral membrane H/OH/HCO3 transport mechanisms along the nephron: role in control of pHi and transepithelial bicarbonate transport.
Preisig PA, Hays SR, Alpern RJ. Basolateral membrane H/OH/HCO3 transport mechanisms along the nephron: role in control of pHi and transepithelial bicarbonate transport. Seminars In Nephrology 1990, 10: 104-14. PMID: 2156327.Peer-Reviewed Original Research
1987
Carbonic Anhydrase Inhibitors
Preisig PA, Toto RD, Alpern RJ. Carbonic Anhydrase Inhibitors. Renal Physiology 1987, 10: 136-159. PMID: 3133728, DOI: 10.1159/000173126.Peer-Reviewed Original Research