A phase Ib dose escalation study of combined inhibition of IDO1 (GDC-0919) and PD-L1 (atezolizumab) in patients (pts) with locally advanced or metastatic solid tumors.
Burris H, Gordon M, Hellmann M, LoRusso P, Emens L, Hodi F, Lieu C, Infante J, Tsai F, Eder J, Cleary J, Jelovac D, Tsuhako A, Mueller L, Lin R, Morrissey K, Mahrus S, Morley R, Pirzkall A, Davis S. A phase Ib dose escalation study of combined inhibition of IDO1 (GDC-0919) and PD-L1 (atezolizumab) in patients (pts) with locally advanced or metastatic solid tumors. Journal Of Clinical Oncology 2017, 35: 105-105. DOI: 10.1200/jco.2017.35.15_suppl.105.Peer-Reviewed Original ResearchMetastatic solid tumorsPD-L1Phase Ib dose-escalation studySolid tumorsEffector T cell activityPrior systemic therapyDose-escalation studyT cell activityPreliminary efficacy dataHeterogeneous patient populationDose-dependent decreaseAnti-tumor activityCombination of GDCSelect tumor typesImmunogenic stateStable diseaseTumor pharmacodynamicsBID dosingExpansion cohortSepsis syndromeTreatment discontinuationEscalation studyPartial responsePlasma kynureninePrior immunotherapy