1994
Antitumour activity of N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxo-9H-thioxanthen-4-yl]methyl]methanesulfonamide (WIN33377) and analogues
Corbett T, Lowichik N, Pugh S, Polin L, Panchapor C, White K, Knight J, Demchik L, Jones J, Jones L, Biernat L, Lorusso P, Foster B, Heilbrun L, Rake J, Mattes K, Perni R, Powles R, Hlavac A, Wentland M, Coughlin S, Baker L, Valeriote F. Antitumour activity of N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxo-9H-thioxanthen-4-yl]methyl]methanesulfonamide (WIN33377) and analogues. Expert Opinion On Investigational Drugs 1994, 3: 1281-1292. DOI: 10.1517/13543784.3.12.1281.Peer-Reviewed Original ResearchLiver toxicityAntitumour activityClinical trialsPhase I clinical trialSevere liver toxicityEfficacious dose levelsPreclinical modelsDose levelsBetter efficacyWeekly scheduleAntischistosomal agentsDay scheduleHycanthoneM2 levelToxicityTrialsMost analoguesAgentsRecovery timeVariety of analoguesGroupActivityMiceDose
1992
Discovery of Solid Tumor Active Agents Using a Soft-Agar-Colony-Formation Disk-Diffusion-Assay
Corbett T, Valeriote F, Polin L, Panchapor C, Pugh S, White K, Lowichik N, Knight J, Bissery M, Wozniak A, LoRusso P, Biernat L, Polin D, Knight L, Biggar S, Looney D, Demchik L, Jones J, Jones L, Blair S, Palmer K, Essenmacher S, Lisow L, Mattes K, Cavanaugh P, Rake J, Baker L. Discovery of Solid Tumor Active Agents Using a Soft-Agar-Colony-Formation Disk-Diffusion-Assay. Developments In Oncology 1992, 35-87. DOI: 10.1007/978-1-4615-3492-1_3.Peer-Reviewed Original ResearchSolid tumorsAvailable antitumor agentsTransplantable solid tumorsSolid tumor activityLymphocytic leukemiaTumor activityClinical developmentProstate tumorsLack of responsivenessTumorsHuman lungTumor systemsHuman tumorsLeukemiaMiceAntitumor drug discoveryAntitumor agentsAgar coloniesResponsivenessAgentsActive agentsDrug discoveryLungClinicColon