1198P FPA150 (B7-H4 antibody) phase I update in advanced solid tumours: Monotherapy and in combination with pembrolizumab
Wainberg Z, Sachdev J, Bauer T, Pant S, Chawla S, Marina N, Xiang H, Deng W, Schmidt M, Patnaik A, LoRusso P. 1198P FPA150 (B7-H4 antibody) phase I update in advanced solid tumours: Monotherapy and in combination with pembrolizumab. Annals Of Oncology 2019, 30: v489. DOI: 10.1093/annonc/mdz253.024.Peer-Reviewed Original ResearchTreatment-related adverse eventsAdvanced solid tumorsB7-H4Prime TherapeuticsSolid tumorsAdverse eventsEli LillyTreatment-related serious adverse eventsAntibody-dependent cell-mediated cytotoxicityAnti-PD1 agentsB7-H4 antibodyDose-proportional exposureSerious adverse eventsDose-limiting toxicityCell-mediated cytotoxicityCommon being diarrheaGlaxo Smith KlineBristol-Myers SquibbDrug discontinuationGuardant HealthKaryopharm TherapeuticsSarcoma AllianceDose expansionDose escalationOngoing trials