The Role of Bisphosphonates in the Treatment of Skeletal Complications of Breast Cancer
El-Rayes B, LoRusso P. The Role of Bisphosphonates in the Treatment of Skeletal Complications of Breast Cancer. American Journal Of Cancer 2004, 3: 369-375. DOI: 10.2165/00024669-200403060-00004.Peer-Reviewed Original ResearchBreast cancerZoledronic acidPamidronic acidIbandronic acidPlacebo-controlled trialSerum creatinine levelsSpinal cord compressionLarge randomized studiesMetastatic breast cancerRole of bisphosphonatesBreast cancer patientsClodronic acidClass of agentsCord compressionGastrointestinal symptomsRenal impairmentSkeletal complicationsSkeletal eventsCreatinine levelsMajor toxicityBone destructionBone metastasesRadiographic evidenceRandomized studySignificant morbidity