2024
Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders
Datta D, Yang S, Joyce M, Woo E, McCarroll S, Gonzalez-Burgos G, Perone I, Uchendu S, Ling E, Goldman M, Berretta S, Murray J, Morozov Y, Arellano J, Duque A, Rakic P, O’Dell R, van Dyck C, Lewis D, Wang M, Krienen F, Arnsten A. Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders. JAMA Psychiatry 2024, 81: 870-881. PMID: 38776078, PMCID: PMC11112502, DOI: 10.1001/jamapsychiatry.2024.1112.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexLayer III pyramidal cellsWorking memoryCognitive disordersNeuronal firingPrimate dorsolateral prefrontal cortexPyramidal cellsSpatial working memoryWorking memory performanceRisk of mental disordersCalcium-related proteinsReduced neuronal firingL-type calcium channel Cav1.2GluN2B-NMDA receptorsL-type calcium channel activityPrefrontal neuronsL-type calcium channel blockerMemory performanceL-type calcium channelsMental disordersRisk of cognitive disordersCognitive behaviorProtein expressionAssociated with increased riskLateral expansion of the mammalian cerebral cortex is related to anchorage of centrosomes in apical neural progenitors
Morozov Y, Rakic P. Lateral expansion of the mammalian cerebral cortex is related to anchorage of centrosomes in apical neural progenitors. Cerebral Cortex 2024, 34: bhae293. PMID: 39024157, DOI: 10.1093/cercor/bhae293.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsProgenitor cellsVentricular zoneCerebral cortexBasolateral cell membraneApical anchorageProlonged neurogenesisMammalian cerebral cortexPrimary ciliaApical neural progenitorsCell membraneFraction of cellsNeural progenitorsStem cellsCerebral neurogenesisApical segmentsDevelopment of ciliaNuclear translocationMicrotubule organizing centerNeurogenesisCellsMacaque monkeysSpecies-specific differencesCortexBasal bodiesCorrelation between the number of interstitial neurons of the white matter and number of neurons within cortical layers: Histological analyses in postnatal macaque
Ahmed B, Duque A, Rakic P, Molnár Z. Correlation between the number of interstitial neurons of the white matter and number of neurons within cortical layers: Histological analyses in postnatal macaque. The Journal Of Comparative Neurology 2024, 532: e25626. PMID: 39031698, PMCID: PMC11262481, DOI: 10.1002/cne.25626.Peer-Reviewed Original ResearchWhite matter interstitial cellsInterstitial neuronsLayer 5Macaque cortexCortical neuronsGyral crownsInterstitial cellsStandardized cell numbersCell numberSulcal regionsDensity of neuronsLinear regionCortical layer thicknessLayer thicknessOverlying cortexCoronal sectionsHistological analysisDensityWhite matterNeuronsLayerCortical layersClinical perspectiveThicknessCortical thicknessModelling adult neurogenesis in the aging rodent hippocampus: a midlife crisis
Arellano J, Rakic P. Modelling adult neurogenesis in the aging rodent hippocampus: a midlife crisis. Frontiers In Neuroscience 2024, 18: 1416460. PMID: 38887368, PMCID: PMC11181911, DOI: 10.3389/fnins.2024.1416460.Peer-Reviewed Original ResearchAdult neurogenesisHippocampal functionAdult hippocampal neurogenesisAged animalsMiddle aged animalsHippocampal neurogenesisGranule cellsDentate gyrusMature granule cellsRodent hippocampusMidlife crisisNeurogenesisFunctional relevanceRodentsDramatically with ageNeuronsYoung animalsOlder animalsGyrusHippocampusRatsRobust neurogenesisHippocampalMeta-analysisDentateA coming-of-age story: adult neurogenesis or adolescent neurogenesis in rodents?
Arellano J, Duque A, Rakic P. A coming-of-age story: adult neurogenesis or adolescent neurogenesis in rodents? Frontiers In Neuroscience 2024, 18: 1383728. PMID: 38505771, PMCID: PMC10948509, DOI: 10.3389/fnins.2024.1383728.Peer-Reviewed Original ResearchAdult hippocampal neurogenesisHippocampal neurogenesisInter-strain differencesOnset of adulthoodAdult neurogenesisAdolescent periodJackson LabsPostnatal dayNeurogenesisAdulthoodDevelopment of miceMonths of ageAdolescentsPostnatal development of miceRatsRodentsPostnatal developmentAdultsOlder animalsComing-of-age storyMiceYounger agePerceived importanceInter-individualFunctional studiesThe analysis of H.M.'s brain: A brief review of status and plans for future studies and tissue archive
Amaral D, Augustinack J, Barbas H, Frosch M, Gabrieli J, Luebke J, Rakic P, Rosene D, Rushmore R. The analysis of H.M.'s brain: A brief review of status and plans for future studies and tissue archive. Hippocampus 2024, 34: 52-57. PMID: 38189522, DOI: 10.1002/hipo.23597.Peer-Reviewed Original Research
2023
Alternative splicing events as peripheral biomarkers for motor learning deficit caused by adverse prenatal environments
Dutta D, Sasaki J, Bansal A, Sugai K, Yamashita S, Li G, Lazarski C, Wang L, Sasaki T, Yamashita C, Carryl H, Suzuki R, Odawara M, Kawasawa Y, Rakic P, Torii M, Hashimoto-Torii K. Alternative splicing events as peripheral biomarkers for motor learning deficit caused by adverse prenatal environments. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2304074120. PMID: 38051767, PMCID: PMC10723155, DOI: 10.1073/pnas.2304074120.Peer-Reviewed Original ResearchLocalization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease
Datta D, Perone I, Morozov Y, Arellano J, Duque A, Rakic P, van Dyck C, Arnsten A. Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease. Cerebral Cortex 2023, 33: 11501-11516. PMID: 37874022, PMCID: PMC10724870, DOI: 10.1093/cercor/bhad382.Peer-Reviewed Original ResearchConceptsHCN1 channelsTau pathologyGlutamate synapsesEntorhinal cortexCalcium actionInternal calcium releaseEntorhinal cortex stellate cellsDorsolateral prefrontal cortexSusceptible neuronsInitial pathologySelective vulnerabilityEtiological factorsTau phosphorylationStellate cellsAlzheimer's diseaseSpecific neuronsCalcium releasePrefrontal cortexCortexSynapse strengthPathologyCalcium signalingCalbindinDiseaseNeuronsMolecular programs of regional specification and neural stem cell fate progression in macaque telencephalon
Micali N, Ma S, Li M, Kim S, Mato-Blanco X, Sindhu S, Arellano J, Gao T, Shibata M, Gobeske K, Duque A, Santpere G, Sestan N, Rakic P. Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon. Science 2023, 382: eadf3786. PMID: 37824652, PMCID: PMC10705812, DOI: 10.1126/science.adf3786.Peer-Reviewed Original ResearchOld Models Know Wrinkles Best
Arellano J, Rakic P. Old Models Know Wrinkles Best. 2023, 499-525. DOI: 10.1002/9781119860914.ch23.Peer-Reviewed Original ResearchOrigin and development of the claustrum in rhesus macaque
Li H, Duque A, Rakic P. Origin and development of the claustrum in rhesus macaque. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2220918120. PMID: 37406098, PMCID: PMC10334778, DOI: 10.1073/pnas.2220918120.Peer-Reviewed Original ResearchDisorder of Golgi Apparatus Precedes Anoxia-Induced Pathology of Mitochondria
Morozov Y, Rakic P. Disorder of Golgi Apparatus Precedes Anoxia-Induced Pathology of Mitochondria. International Journal Of Molecular Sciences 2023, 24: 4432. PMID: 36901863, PMCID: PMC10003327, DOI: 10.3390/ijms24054432.Peer-Reviewed Original ResearchConceptsGolgi apparatusH anoxiaPost-translational protein modificationStomatin-like protein 2Role of mitochondriaEmbryonic mouse brainEmbryonic mouse brain cellsGolgi architectureSecretory traffickingMitochondrial matrixProtein modificationMouse brain cellsMitochondrial malfunctionTrans cisternaeBrain cellsMitochondriaOrganellesProtein 2Mitochondrial disordersLateral ganglionic eminenceEarly eventsComplex pathological changesMouse brainNormal ultrastructureGanglionic eminenceLaminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization
Junaković A, Kopić J, Duque A, Rakic P, Krsnik Ž, Kostović I. Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization. Brain Structure And Function 2023, 228: 613-633. PMID: 36592215, PMCID: PMC9944618, DOI: 10.1007/s00429-022-02606-7.Peer-Reviewed Original Research
2022
Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex
Rash B, Arellano J, Duque A, Rakic P. Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 120: e2210967120. PMID: 36574666, PMCID: PMC9910595, DOI: 10.1073/pnas.2210967120.Peer-Reviewed Original ResearchConceptsOuter subventricular zoneSubcortical white matterCerebral cortexWhite matterFormation of gyriPrimate cerebral cortexMammalian cerebral cortexMarkers of proliferationCortical malformationsCortical plateGlial cellsGyral developmentSubventricular zoneCortical neurogenesisFetal developmentVentricular zoneCortical foldingNeuronal progenitorsGyrificationNeuronal growthNeuropil growthPrimary gyriCortexNeurodevelopmental disordersGyrusNeural Stem Cells in Adult Mammals are not Astrocytes
Velloso F, Shankar S, Parpura V, Rakic P, Levison S. Neural Stem Cells in Adult Mammals are not Astrocytes. ASN Neuro 2022, 14: 17590914221134739. PMID: 36330653, PMCID: PMC9638700, DOI: 10.1177/17590914221134739.Peer-Reviewed Original ResearchConceptsAdult mammalian subventricular zoneNeural stem cellsMammalian subventricular zoneMammalian neural stem cellsComparative transcriptomic analysisDistinct gene expression profilesStem cellsAdult mammalian neural stem cellsGene expression profilesSingle-cell RNAseqFunction of NSCsMurine neural stem cellsSubventricular zoneTranscriptomic analysisExpression profilesAdult murine neural stem cellsCell sortingAdult mammalsFunction of astrocytesCellsNew neuronsSubtypes of astrocytesMammalsRNAseqNiche
2020
Cerebral Cortex Communications Inaugural Editorial
Rakic P. Cerebral Cortex Communications Inaugural Editorial. Cerebral Cortex Communications 2020, 1: tgaa001. PMID: 34296083, PMCID: PMC8151796, DOI: 10.1093/texcom/tgaa001.Commentaries, Editorials and Letters
2019
Introduction
Singer W, Sejnowski T, Rakic P. Introduction. 2019, 13-20. DOI: 10.7551/mitpress/12593.003.0003.Peer-Reviewed Original ResearchEvolution and Ontogenetic Development of Cortical Structures
Silver D, Rakic P, Grove E, Haydar T, Hensch T, Huttner W, Molnár Z, Rubenstein J, Sestan N, Stryker M, Sur M, Tosches M, Walsh C. Evolution and Ontogenetic Development of Cortical Structures. 2019, 73-106. DOI: 10.7551/mitpress/12593.003.0008.Peer-Reviewed Original Research
2018
Understanding Effects of Experience on Neurocognitive Development through the Lens of Early Adolescence
Bedny M, Paus T, Doesburg S, Giedd J, Hashemiyoon R, Kolb B, Purdon P, Rakic P, Sisk C. Understanding Effects of Experience on Neurocognitive Development through the Lens of Early Adolescence. 2018, 179-196. DOI: 10.7551/mitpress/11957.003.0013.Peer-Reviewed Original Research
2015
Identification of Proliferating and Migrating Cells by BrdU and Other Thymidine Analogs: Benefits and Limitations
Duque A, Rakic P. Identification of Proliferating and Migrating Cells by BrdU and Other Thymidine Analogs: Benefits and Limitations. Neuromethods 2015, 101: 123-139. DOI: 10.1007/978-1-4939-2313-7_7.Publications for non-academic audiences