2014
Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia
Brennand K, Savas J, Kim Y, Tran N, Simone A, Hashimoto-Torii K, Beaumont K, Kim H, Topol A, Ladran I, Abdelrahim M, Matikainen-Ankney B, Chao S, Mrksich M, Rakic P, Fang G, Zhang B, Yates J, Gage F. Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. Molecular Psychiatry 2014, 20: 361-368. PMID: 24686136, PMCID: PMC4182344, DOI: 10.1038/mp.2014.22.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntipsychotic AgentsCell DifferentiationCell MovementCells, CulturedFemaleGene ExpressionHumansMaleMiceMice, Inbred C57BLMice, TransgenicMitochondriaNeural Cell Adhesion MoleculesNeural Stem CellsOxidative StressPhenotypePluripotent Stem CellsProsencephalonProteomicsReactive Oxygen SpeciesSchizophreniaYoung AdultConceptsHiPSC neural progenitor cellsNeural progenitor cellsHuman-induced pluripotent stem cellsHiPSC-derived neuronsGene expressionGene expression comparisonsStable isotope labelingProteomic mass spectrometry analysisAbnormal gene expressionPluripotent stem cellsOxidative stressCytoskeletal remodelingMass spectrometry analysisCellular phenotypesExpression comparisonsDevelopmental mechanismsIsotope labelingPhenotypic differencesBrainSpan AtlasDisease predispositionAmino acidsScalable assayNPC phenotypeStem cellsProgenitor cells
2009
Selective reduction of neuron number and volume of the mediodorsal nucleus of the thalamus in macaques following irradiation at early gestational ages
Selemon LD, Begović A, Rakic P. Selective reduction of neuron number and volume of the mediodorsal nucleus of the thalamus in macaques following irradiation at early gestational ages. The Journal Of Comparative Neurology 2009, 515: 454-464. PMID: 19459221, PMCID: PMC2716797, DOI: 10.1002/cne.22078.Peer-Reviewed Original Research
2001
Cell Proliferation Without Neurogenesis in Adult Primate Neocortex
Kornack D, Rakic P. Cell Proliferation Without Neurogenesis in Adult Primate Neocortex. Science 2001, 294: 2127-2130. PMID: 11739948, DOI: 10.1126/science.1065467.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBrainBromodeoxyuridineCell DeathCell DivisionCell MovementEndothelium, VascularFemaleFluorescent Antibody TechniqueGlial Fibrillary Acidic ProteinImmunoenzyme TechniquesMacaca fascicularisMacaca mulattaMaleMicroscopy, ConfocalMicroscopy, FluorescenceNeocortexNeuronsNuclear ProteinsTubulinConceptsPrimate neocortexGlial cell markersAdult macaque monkeysNew neuronsNumerous BrdUOlfactory bulbCerebral wallAdult macaquesMacaque monkeysNonneuronal cellsHigher cognitive functionsCell markersCognitive functionNeocortexNeurogenesisTriple labelingCellular mechanismsCell proliferationNeuronsCellsHippocampus
2000
Amyloid Beta-Induced Neuronal Death is Bax-Dependent but Caspase-Independent
Selznick L, Zheng T, Flavell R, Rakic P, Roth K. Amyloid Beta-Induced Neuronal Death is Bax-Dependent but Caspase-Independent. Journal Of Neuropathology & Experimental Neurology 2000, 59: 271-279. PMID: 10759182, DOI: 10.1093/jnen/59.4.271.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid Chloromethyl KetonesAmyloid beta-PeptidesAnimalsApoptosisBcl-2-Associated X ProteinCaspase 3Caspase InhibitorsCaspasesCell DeathCells, CulturedCysteine Proteinase InhibitorsDose-Response Relationship, DrugFemaleGlycoproteinsIn Situ Nick-End LabelingMaleMiceMice, KnockoutMicrotubule-Associated ProteinsMicrotubulesNeuronsPaclitaxelProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2TelencephalonConceptsNeuronal deathNeuronal apoptosisCaspase-3 activationTelencephalic neuronsFibrillar amyloid-beta (Abeta) peptidesAbeta-induced neuronal apoptosisAD treatment strategiesAbeta-induced neuronal deathPathogenesis of ADAlzheimer's disease brainEffects of AbetaAmyloid-beta peptideApoptotic nuclear featuresUnderlying pathophysiologyTreatment strategiesDisease brainSenile plaquesNeurotoxic effectsAmyloid betaCalpain inhibitionPharmacological inhibitionBeta peptideNuclear featuresAbetaCaspase-3
1999
Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian
Qi H, Rand M, Wu X, Sestan N, Wang W, Rakic P, Xu T, Artavanis-Tsakonas S. Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian. Science 1999, 283: 91-94. PMID: 9872749, DOI: 10.1126/science.283.5398.91.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell LineCells, CulturedDisintegrinsDrosophilaDrosophila ProteinsFemaleIntracellular Signaling Peptides and ProteinsLigandsMaleMembrane ProteinsMetalloendopeptidasesMolecular Sequence DataMutationNeuronsProtein Processing, Post-TranslationalReceptors, NotchSignal TransductionTransfectionConceptsLigand DeltaMetalloprotease KuzbanianCell fate determinationNotch ligand DeltaFate determinationNotch proteinsTransmembrane ligandsNotch activityProcessing eventsExtracellular fragmentGenetic analysisNotch ligandsSurface receptorsKuzbanianAdjacent cellsSoluble formBroad spectrumNotchSignalingProteinLigandsCellsFragmentsVivoReceptors
1998
Changes in cell-cycle kinetics during the development and evolution of primate neocortex
Kornack D, Rakic P. Changes in cell-cycle kinetics during the development and evolution of primate neocortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 1242-1246. PMID: 9448316, PMCID: PMC18732, DOI: 10.1073/pnas.95.3.1242.Peer-Reviewed Original ResearchConceptsCell divisionCell division cycleCell cycle kineticsProgenitor cell divisionCell cycle lengthCell cycle durationEvolutionary modificationsEvolutionary expansionCerebral ventricular zoneDevelopmental basisCell productionPrimate neocortexS-phase labelingAnthropoid primatesProgenitor cellsFetal rhesus monkeysNeurogenetic periodVentricular zoneNeocortical sizeCortical cellsNeurogenesisCortical developmentMonkey cortexTotal roundsCortical layersPeptidergic innervation and the nicotinic acetylcholine receptor in the primate basal nucleus
Csillik B, Rakic P, Knyihár‐Csillik E. Peptidergic innervation and the nicotinic acetylcholine receptor in the primate basal nucleus. European Journal Of Neuroscience 1998, 10: 573-585. PMID: 9749720, DOI: 10.1046/j.1460-9568.1998.00066.x.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptidePrincipal nerve cellsNeuropeptide YNicotinic acetylcholine receptorsSubstance PBasal nucleusAcetylcholine receptorsPeptidergic innervationBasal forebrainPrincipal cellsElectron microscopic pre-embedding immunocytochemistryAlpha-BTXNerve cellsNeuronal nicotinic acetylcholine receptorsMeynert's basal nucleusCholine acetyltransferase immunoreactivityGene-related peptideImmunohistochemical double stainingPre-embedding immunocytochemistryImmunopositive axonsPresynaptic nAChRsCGRP immunoreactivityAcetylcholine releaseNeuronal nAChRsGlomerular arrangement
1997
Dorsal root origin of axonal growth cones: regenerative synapto-neogenesis in the upper spinal dorsal horn of primates.
Knyihár-Csillik E, Seres L, Rakic P, Csillik B. Dorsal root origin of axonal growth cones: regenerative synapto-neogenesis in the upper spinal dorsal horn of primates. Ideggyógyászati Szemle 1997, 5: 481-8. PMID: 9591285.Peer-Reviewed Original Research
1996
Numerical relationship between neurons in the lateral geniculate nucleus and primary visual cortex in macaque monkeys
Suner I, Rakic P. Numerical relationship between neurons in the lateral geniculate nucleus and primary visual cortex in macaque monkeys. Visual Neuroscience 1996, 13: 585-590. PMID: 8782386, DOI: 10.1017/s0952523800008269.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusArea 17Primary visual cortexGeniculate nucleusVisual cortexThree-dimensional counting methodTotal neuron numberNormal rhesus monkeysVisual centersCerebral hemispheresMacaque monkeysRhesus monkeysNeuron numberNeuronsNumber of neuronsRight sideCortexTotal populationMonkeysMultiple factorsSame side
1994
Unique profiles of the alpha 1-, alpha 2-, and beta-adrenergic receptors in the developing cortical plate and transient embryonic zones of the rhesus monkey
Lidow, Rakic P. Unique profiles of the alpha 1-, alpha 2-, and beta-adrenergic receptors in the developing cortical plate and transient embryonic zones of the rhesus monkey. Journal Of Neuroscience 1994, 14: 4064-4078. PMID: 8027763, PMCID: PMC6577033, DOI: 10.1523/jneurosci.14-07-04064.1994.Peer-Reviewed Original ResearchConceptsTransient embryonic zonesBeta-adrenergic receptorsCortical plateAdrenergic receptor subtypesSubplate zoneReceptor subtypesCerebral wallRhesus monkeysAlpha 1Alpha 1 sitesAlpha 2Alpha 2 receptorsAlpha 1 receptorsEmbryonic zonesIntensive proliferative activityReceptor autoradiographyCortical neuronsSubventricular zoneCortical developmentOccipital lobeBeta receptorsAdrenergic receptorsAdrenergic sitesVisual cortexGerminal zoneSynaptogenesis in the Prefrontal Cortex of Rhesus Monkeys
Bourgeois J, Goldman-Rakic P, Rakic P. Synaptogenesis in the Prefrontal Cortex of Rhesus Monkeys. Cerebral Cortex 1994, 4: 78-96. PMID: 8180493, DOI: 10.1093/cercor/4.1.78.Peer-Reviewed Original ResearchConceptsYears of ageSynaptic densityPrefrontal cortexCortical plateMotor areaRhesus monkeysDensity of synapsesQuantitative electron microscopic analysisCourse of synaptogenesisHigh synaptic densityWhole cortical thicknessPrefrontal association areasMacaque prefrontal cortexCerebral cortexDendritic shaftsSupragranular layersCortical circuitryCortical thicknessCortical mantleAssociation areasSynapse formationDay 47Selective increaseCortexSynapses
1993
Distribution of calcitonin gene-related peptide in vertebrate neuromuscular junctions: relationship to the acetylcholine receptor.
Csillik B, Tajti L, Kovács T, Kukla E, Rakic P, Knyihár-Csillik E. Distribution of calcitonin gene-related peptide in vertebrate neuromuscular junctions: relationship to the acetylcholine receptor. Journal Of Histochemistry & Cytochemistry 1993, 41: 1547-1555. PMID: 8245413, DOI: 10.1177/41.10.8245413.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptideGene-related peptideCGRP immunoreactivityMotor endplatesMotor axonsNeuromuscular junctionAcetylcholine receptorsWallerian degenerationAccumulation of CGRPTonic musclesPresence of CGRPNeuromuscular transmission resultsRat muscleMotor nerve endingsChloral hydrate anesthesiaPresynaptic axon terminalsMotor nervesBupivacaine injectionNerve endingsSupramaximal stimulationAxon terminalsAxon regenerationVertebrate neuromuscular junctionTetanic muscleBuccinator muscleChanges of synaptic density in the primary visual cortex of the macaque monkey from fetal to adult stage
Bourgeois J, Rakic P. Changes of synaptic density in the primary visual cortex of the macaque monkey from fetal to adult stage. Journal Of Neuroscience 1993, 13: 2801-2820. PMID: 8331373, PMCID: PMC6576672, DOI: 10.1523/jneurosci.13-07-02801.1993.Peer-Reviewed Original ResearchConceptsPrimary visual cortexSynaptic contactsVisual cortexCortical plateSynaptic densityDendritic spinesPostnatal yearDensity of synapsesThird postnatal monthFirst postnatal yearTime of pubertyMicrons 3Asymmetric synapsesDendritic shaftsLayer VICalcarine fissureCortical neuronsLayer IVPostnatal monthLaminar positionMacaque monkeysFunctional maturationRhesus monkeysAdult levelsNeuropil
1992
Immunocytochemical localization of DARPP‐32, a dopamine and cyclic‐ AMP‐regulated phosphoprotein, in the primate brain
Ouimet C, Lamantia A, Goldman‐Rakic P, Rakic P, Greengard P. Immunocytochemical localization of DARPP‐32, a dopamine and cyclic‐ AMP‐regulated phosphoprotein, in the primate brain. The Journal Of Comparative Neurology 1992, 323: 209-218. PMID: 1328330, DOI: 10.1002/cne.903230206.Peer-Reviewed Original ResearchConceptsDARPP-32Axon terminalsCaudate nucleusDARPP-32-positive neuronsSubstantia nigra pars reticulataAnterior olfactory areaMajority of somataSubcortical white matterUnlabeled axon terminalsAction of dopamineVentral tegmental areaDARPP-32 immunoreactivityCerebral cortexPars reticulataDopaminergic neuronsImmunoreactive somataSubstantia nigraArcuate nucleusGlobus pallidusTegmental areaMedial habenulaDopamine receptorsOlfactory areasVentral pallidumBed nucleusScheduling of Monoaminergic Neurotransmitter Receptor Expression in the Primate Neocortex during Postnatal Development
Lidow M, Rakic P. Scheduling of Monoaminergic Neurotransmitter Receptor Expression in the Primate Neocortex during Postnatal Development. Cerebral Cortex 1992, 2: 401-416. PMID: 1330122, DOI: 10.1093/cercor/2.5.401.Peer-Reviewed Original ResearchConceptsMonoaminergic receptorsCortical layersReceptor densityCytoarchitectonic areasPostnatal developmentNeurotransmitter receptor expressionSuperficial cortical layersMonths of ageTime of pubertyCerebral cortexCortical maturationPostnatal monthReceptor expressionPrimary motorPrimate neocortexVisual cortexRhesus monkeysFourth monthReceptorsMonthsReceptor sitesCortexDevelopmental changesDevelopmental courseTransient overproduction
1990
Photoreceptor mosaic: Number and distribution of rods and cones in the rhesus monkey retina
Wikler K, Williams R, Rakic P. Photoreceptor mosaic: Number and distribution of rods and cones in the rhesus monkey retina. The Journal Of Comparative Neurology 1990, 297: 499-508. PMID: 2384610, DOI: 10.1002/cne.902970404.Peer-Reviewed Original ResearchConceptsCone densityEntire retinal surfaceRods/mm2Rhesus monkey retinaCones/mm2Adult rhesus monkeysRetinal surface areaDensity of rodsDistribution of photoreceptorsNasal retinaRod densityMonkey retinaVideo-enhanced differential interference contrast opticsDistribution of rodsReceptor densityExtrafoveal retinaRetinal surfaceProportion of rodsRhesus monkeysScotopic conditionsRetinaArea 4Absolute numberRetinal developmentPhotopic systemCytological and quantitative characteristics of four cerebral commissures in the rhesus monkey
Lamantia A, Rakic P. Cytological and quantitative characteristics of four cerebral commissures in the rhesus monkey. The Journal Of Comparative Neurology 1990, 291: 520-537. PMID: 2329189, DOI: 10.1002/cne.902910404.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinAnterior commissureCorpus callosumHippocampal commissureTelencephalic commissuresCerebral commissureNeocortical commissuresUnmyelinated axonsRhesus monkeysNumber of axonsPrimary sensory cortexGFAP-positive cellsFibrillary acidic proteinLarge myelinated axonsQuantitative electron microscopic analysisClasses of axonsNumerous desmosomal junctionsAdult rhesus monkeysAxonal compositionOpposite cerebralNeurons projectAssociation projectionsUnmyelinated fibersAxonal fasciclesGlia cells
1989
Dopamine D2 receptors in the cerebral cortex: distribution and pharmacological characterization with [3H]raclopride.
Lidow M, Goldman-Rakic P, Rakic P, Innis R. Dopamine D2 receptors in the cerebral cortex: distribution and pharmacological characterization with [3H]raclopride. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 6412-6416. PMID: 2548214, PMCID: PMC297850, DOI: 10.1073/pnas.86.16.6412.Peer-Reviewed Original ResearchConceptsDopamine D2 receptorsD2 receptorsD2 sitesDopamine D1 receptorsNeostriatum of ratsD2-selective antagonistRostral-caudal gradientCerebral cortexDopaminergic innervationD1 receptorsDopamine levelsDopamine receptorsPharmacological characterizationRat cortexSelective antagonistOccipital cortexPharmacological profileCognitive functionCortexReceptorsNeostriatumApparent involvementPresent studySaturable mannerMonkeysQuantitative autoradiographic mapping of serotonin 5‐HT1 and 5‐HT2 receptors and uptake sites in the neocortex of the rhesus monkey
Lidow M, Goldman‐Rakic P, Gallager D, Rakic P. Quantitative autoradiographic mapping of serotonin 5‐HT1 and 5‐HT2 receptors and uptake sites in the neocortex of the rhesus monkey. The Journal Of Comparative Neurology 1989, 280: 27-42. PMID: 2918094, DOI: 10.1002/cne.902800104.Peer-Reviewed Original ResearchConceptsLayer IIIReceptor subtypesUptake sitesCortical areasVisual cortexLayer IRhesus monkeysPrimary motor cortexSerotonin uptake sitesQuantitative autoradiographic mappingMonkey cerebral cortexDistribution of serotoninPrimary visual cortexPattern of distributionIVC betaAutoradiographic mappingCerebral cortexMotor cortexLayer IVCortical functionOccipital lobePrimary motorPrestriate cortexReceptor distributionCortexDistribution of major neurotransmitter receptors in the motor and somatosensory cortex of the rhesus monkey
Lidow M, Goldman-Rakic P, Gallager D, Geschwind D, Rakic P. Distribution of major neurotransmitter receptors in the motor and somatosensory cortex of the rhesus monkey. Neuroscience 1989, 32: 609-627. PMID: 2557559, DOI: 10.1016/0306-4522(89)90283-2.Peer-Reviewed Original ResearchConceptsMotor cortexSomatosensory cortexRhesus monkeysNeurotransmitter receptorsMajor neurotransmitter receptorsQuantitative autoradiographic techniqueAdult rhesus monkeysReceptor autoradiographyLaminar distributionReceptor subtypesMotor areaBenzodiazepine receptorsLayer IIIClassical histological techniquesLayer ID2 dopaminergicCortexAutoradiographic techniquesBeta 1Same receptorAlpha 1Alpha 2Different receptorsReceptorsCoextensive distribution