1997
Early divergence of magnocellular and parvocellular functional subsystems in the embryonic primate visual system
Meissirel C, Wikler K, Chalupa L, Rakic P. Early divergence of magnocellular and parvocellular functional subsystems in the embryonic primate visual system. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 5900-5905. PMID: 9159172, PMCID: PMC20878, DOI: 10.1073/pnas.94.11.5900.Peer-Reviewed Original ResearchRadiation‐induced, lamina‐specific deletion of neurons in the primate visual cortex
Algan O, Rakic P. Radiation‐induced, lamina‐specific deletion of neurons in the primate visual cortex. The Journal Of Comparative Neurology 1997, 381: 335-352. PMID: 9133572, DOI: 10.1002/(sici)1096-9861(19970512)381:3<335::aid-cne6>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusArea 17Primate visual cortexVisual cortexLow dosesCortical layersArea 17/18 borderEmbryonic day 80Period of corticogenesisSuperficial cortical layersOnset of corticogenesisComputer-aided morphometryMacaque monkey brainSpecific cell classesMultiple dosesCortical cytoarchitectureGeniculate nucleusCortical developmentLaminar positionSpecific neuronal classesCortical thicknessPrimate brainMonkey brainCytoarchitectonic featuresHigh doses
1996
Numerical relationship between neurons in the lateral geniculate nucleus and primary visual cortex in macaque monkeys
Suner I, Rakic P. Numerical relationship between neurons in the lateral geniculate nucleus and primary visual cortex in macaque monkeys. Visual Neuroscience 1996, 13: 585-590. PMID: 8782386, DOI: 10.1017/s0952523800008269.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CountDominance, CerebralGeniculate BodiesIn Vitro TechniquesMacaca mulattaMaleNeuronsVisual CortexConceptsLateral geniculate nucleusArea 17Primary visual cortexGeniculate nucleusVisual cortexThree-dimensional counting methodTotal neuron numberNormal rhesus monkeysVisual centersCerebral hemispheresMacaque monkeysRhesus monkeysNeuron numberNeuronsNumber of neuronsRight sideCortexTotal populationMonkeysMultiple factorsSame sideSynaptogenesis in the Occipital Cortex of Macaque Monkey Devoid of Retinal Input From Early Embryonic Stages
Bourgeois J, Rakic P. Synaptogenesis in the Occipital Cortex of Macaque Monkey Devoid of Retinal Input From Early Embryonic Stages. European Journal Of Neuroscience 1996, 8: 942-950. PMID: 8743742, DOI: 10.1111/j.1460-9568.1996.tb01581.x.Peer-Reviewed Original ResearchConceptsAge-matched controlsStriate cortexDendritic spinesSynaptic contactsRetinal inputInfragranular cortical layersRatio of synapsesLateral geniculate nucleusPrimate striate cortexVolume of neuropilGroups of animalsEarly embryonic stagesAsymmetrical synapsesInfragranular layersSynaptic organizationGeniculate nucleusOccipital cortexNormal rangeOperated animalsSynaptic circuitsMacaque monkeysCortical layersEnucleated animalsSynaptic developmentDay 67
1988
Elimination of neurons from the rhesus monkey's lateral geniculate nucleus during development
Williams R, Rakic P. Elimination of neurons from the rhesus monkey's lateral geniculate nucleus during development. The Journal Of Comparative Neurology 1988, 272: 424-436. PMID: 3417894, DOI: 10.1002/cne.902720310.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CountEmbryonic and Fetal DevelopmentGeniculate BodiesImmunochemistryMacacaMacaca mulattaNerve DegenerationNeuronsConceptsLateral geniculate nucleusGeniculate nucleusDorsal lateral geniculate nucleusDepletion of neuronsElimination of neuronsDays of gestationOcular dominance columnsMonkey lateral geniculate nucleusEmbryonic day 60Geniculocortical connectionsGeniculate neuronsDegenerating neuronsVideo-enhanced differential interference contrast opticsMagnocellular partNeuron eliminationRetinal axonsParvicellular partRetinal cellsRhesus monkeysDay 60Left sideNeuronsNumber of neuronsMiddle thirdDegenerating cells
1983
Geniculo-Cortical Connections in Primates: Normal and Experimentally Altered Development
Rakic P. Geniculo-Cortical Connections in Primates: Normal and Experimentally Altered Development. Progress In Brain Research 1983, 58: 393-404. PMID: 6195694, DOI: 10.1016/s0079-6123(08)60042-4.Peer-Reviewed Original ResearchConceptsVisual cortexDorsal lateral geniculate nucleusFetal rhesus monkeysLateral geniculate nucleusCentral visual pathwaysPrimary visual cortexPrimate visual cortexSynaptic reorganizationCerebral cortexPrenatal mechanismsGeniculate nucleusAfferent connectionsAdult monkeysVisual pathwayRhesus monkeysAnatomical organizationExperimental modelCortexCongenital disorderNormal patternPathological developmentMonkeysColor visionSeries of studiesPrimates
1981
Development of Visual Centers in the Primate Brain Depends on Binocular Competition Before Birth
Rakic P. Development of Visual Centers in the Primate Brain Depends on Binocular Competition Before Birth. Science 1981, 214: 928-931. PMID: 7302569, DOI: 10.1126/science.7302569.Peer-Reviewed Original ResearchConceptsVisual centersPrimate brainAberrant synaptic connectionsLateral geniculate nucleusOcular dominance columnsGeniculate neuronsGeniculate nucleusSynaptic connectivityIntact eyeVisual cortexSynaptic connectionsBinocular competitionCellular layersBrainBirthNotable alterationsEyesNormal inputFiber bandsCortexNeuronsThe genesis of efferent connections from the visual cortex of the fetal rhesus monkey
Shatz C, Rakic P. The genesis of efferent connections from the visual cortex of the fetal rhesus monkey. The Journal Of Comparative Neurology 1981, 196: 287-307. PMID: 7217358, DOI: 10.1002/cne.901960208.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusInfragranular cortical layersFetal rhesus monkeysSuperior colliculusRhesus monkeysCortical projectionsPyramidal neuronsVisual cortexCortical layersSubcortical structuresDorsal lateral geniculate nucleusTopographic orderCell-poor zoneCorticogeniculate projectionsSuperficial grayAfferent pathwaysCortical efferentsCortical injectionsEfferent pathwaysCortical plateDendritic arborizationArea 17Pyramidal cellsEfferent connectionsGeniculate nucleus
1977
Genesis of the dorsal lateral geniculate nucleus in the rhesus monkey: Site and time of origin, kinetics of proliferation, routes of migration and pattern of distribution of neurons
Rakic P. Genesis of the dorsal lateral geniculate nucleus in the rhesus monkey: Site and time of origin, kinetics of proliferation, routes of migration and pattern of distribution of neurons. The Journal Of Comparative Neurology 1977, 176: 23-52. PMID: 409739, DOI: 10.1002/cne.901760103.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyCell MovementGeniculate BodiesHaplorhiniHumansMacaca mulattaMitosisRetinaSpecies SpecificityConceptsLateral geniculate bodyH3-TdRAnalysis of embryosExamination of embryosLast cell divisionGeneration of neuronsCell divisionCellular fasciclesPostmitotic cellsThird ventricleTime of originRoute of migrationPattern of distributionRhesus monkeysDorsal lateral geniculate bodyPrecursor neuronsDorsal lateral geniculate nucleusKinetics of proliferationEarly postnatal daysLateral geniculate nucleusVentricular zoneGerminal zoneProliferative unitsMonths of gestationEmbryosPrenatal development of the visual system in rhesus monkey
Rakic P, Barlow H, Gaze R. Prenatal development of the visual system in rhesus monkey. Philosophical Transactions Of The Royal Society B Biological Sciences 1977, 278: 245-260. PMID: 19781, DOI: 10.1098/rstb.1977.0040.Peer-Reviewed Original ResearchConceptsLateral geniculate bodyRetinal ganglion cellsSuperior colliculusOcular dominance columnsLayer IVFirst retinal ganglion cellsRhesus monkeysDorsal lateral geniculate bodySegregation of afferentsPrenatal developmentAnterograde axoplasmic transportEarly postnatal daysProduction of neuronsPrimary visual cortexJuvenile rhesus monkeysSC projectionsEye injectionTransneuronal transportGeniculate bodyCortical plateGanglion cellsGeniculocortical axonsOptic radiationPostnatal dayOcular dominance
1976
Prenatal genesis of connections subserving ocular dominance in the rhesus monkey
Rakic P. Prenatal genesis of connections subserving ocular dominance in the rhesus monkey. Nature 1976, 261: 467-471. PMID: 819835, DOI: 10.1038/261467a0.Peer-Reviewed Original Research