2023
Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease
Datta D, Perone I, Morozov Y, Arellano J, Duque A, Rakic P, van Dyck C, Arnsten A. Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease. Cerebral Cortex 2023, 33: 11501-11516. PMID: 37874022, PMCID: PMC10724870, DOI: 10.1093/cercor/bhad382.Peer-Reviewed Original ResearchConceptsHCN1 channelsTau pathologyGlutamate synapsesEntorhinal cortexCalcium actionInternal calcium releaseEntorhinal cortex stellate cellsDorsolateral prefrontal cortexSusceptible neuronsInitial pathologySelective vulnerabilityEtiological factorsTau phosphorylationStellate cellsAlzheimer's diseaseSpecific neuronsCalcium releasePrefrontal cortexCortexSynapse strengthPathologyCalcium signalingCalbindinDiseaseNeurons
2010
Gap Junctions/Hemichannels Modulate Interkinetic Nuclear Migration in the Forebrain Precursors
Liu X, Hashimoto-Torii K, Torii M, Ding C, Rakic P. Gap Junctions/Hemichannels Modulate Interkinetic Nuclear Migration in the Forebrain Precursors. Journal Of Neuroscience 2010, 30: 4197-4209. PMID: 20335455, PMCID: PMC2861434, DOI: 10.1523/jneurosci.4187-09.2010.Peer-Reviewed Original Research4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAdenosine TriphosphateAnimalsBoron CompoundsBromodeoxyuridineCalciumCalcium SignalingCarbenoxoloneCell Line, TumorCell MovementCell NucleusCerebral VentriclesChelating AgentsConnexin 43Cyclooxygenase InhibitorsEgtazic AcidEmbryo, MammalianFemaleGap JunctionsGreen Fluorescent ProteinsKi-67 AntigenMeclofenamic AcidMiceNeuroblastomaNeuronsOrgan Culture TechniquesPatch-Clamp TechniquesPlatelet Aggregation InhibitorsPregnancyProsencephalonPyridoxal PhosphateStem Cells
1996
Intracellular Ca2+ Fluctuations Modulate the Rate of Neuronal Migration
Komuro H, Rakic P. Intracellular Ca2+ Fluctuations Modulate the Rate of Neuronal Migration. Neuron 1996, 17: 275-285. PMID: 8780651, DOI: 10.1016/s0896-6273(00)80159-2.Peer-Reviewed Original Research
1995
The role of receptor/channel activity in neuronal cell migration
Rakic P, Komuro H. The role of receptor/channel activity in neuronal cell migration. Developmental Neurobiology 1995, 26: 299-315. PMID: 7775964, DOI: 10.1002/neu.480260303.Peer-Reviewed Original ResearchConceptsNeuronal cell migrationCell migrationIon channelsLocal cellular milieuSpecific ion channelsCell motilityCytoskeletal proteinsConfocal laser microscopyCellular milieuPostmitotic neuronsSecond messengerCellular mechanismsChannel activityLaser microscopyMotilitySynaptic connectionsExplant culturesEarly interactionsCellsFluorescent indicatorProteinMessengerMigrationPrior formationCarbocyanine dye
1993
Modulation of Neuronal Migration by NMDA Receptors
Komuro H, Rakic P. Modulation of Neuronal Migration by NMDA Receptors. Science 1993, 260: 95-97. PMID: 8096653, DOI: 10.1126/science.8096653.Peer-Reviewed Original ResearchConceptsNMDA receptorsN-methyl-D-aspartate (NMDA) subtypeEndogenous extracellular glutamateCell migrationNMDA receptor activityElimination of synapsesApplication of glycineSynaptic contactsSlice preparationExtracellular glutamateGlutamate receptorsSpecific antagonistGranule cellsReceptor activityNeuronal migrationNeuronal differentiationReceptorsMouse cerebellumEarly roleBlockadeAntagonistCerebellumSubtypesNeuronsBrain
1992
Selective Role of N-Type Calcium Channels in Neuronal Migration
Komuro H, Rakic P. Selective Role of N-Type Calcium Channels in Neuronal Migration. Science 1992, 257: 806-809. PMID: 1323145, DOI: 10.1126/science.1323145.Peer-Reviewed Original ResearchConceptsN-type calcium channelsCalcium channelsNeuronal migrationT-type calcium channelsCerebellar slice preparationGranule cell migrationImmature neuronsSelective blockadeSlice preparationPostmitotic granule cellsAdult brainGranule cellsSynaptic circuitsNeurotransmitter releasePotassium channelsPlasmalemmal surfaceIncubation mediumCell migrationSelective roleLaser scanning confocal microscopeScanning confocal microscopeBlockadeSpecific developmental roleNeuronsBrain
1989
Dopamine D2 receptors in the cerebral cortex: distribution and pharmacological characterization with [3H]raclopride.
Lidow M, Goldman-Rakic P, Rakic P, Innis R. Dopamine D2 receptors in the cerebral cortex: distribution and pharmacological characterization with [3H]raclopride. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 6412-6416. PMID: 2548214, PMCID: PMC297850, DOI: 10.1073/pnas.86.16.6412.Peer-Reviewed Original ResearchConceptsDopamine D2 receptorsD2 receptorsD2 sitesDopamine D1 receptorsNeostriatum of ratsD2-selective antagonistRostral-caudal gradientCerebral cortexDopaminergic innervationD1 receptorsDopamine levelsDopamine receptorsPharmacological characterizationRat cortexSelective antagonistOccipital cortexPharmacological profileCognitive functionCortexReceptorsNeostriatumApparent involvementPresent studySaturable mannerMonkeys