2000
Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones
Haydar T, Wang F, Schwartz M, Rakic P. Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones. Journal Of Neuroscience 2000, 20: 5764-5774. PMID: 10908617, PMCID: PMC3823557, DOI: 10.1523/jneurosci.20-15-05764.2000.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsAntimetabolitesBromodeoxyuridineCell DifferentiationCell DivisionCell MovementCerebral VentriclesClone CellsExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsFetusGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGlutamic AcidKainic AcidMiceMice, Inbred ICRMuscimolNeocortexNeuronsOrgan Culture TechniquesStem CellsConceptsVentricular zoneNeural progenitor populationsNeural progenitor proliferationSubventricular zoneProgenitor populationsCell cycleProgenitor cloneProgenitor proliferationEmbryonic cerebrumNeocortical growthProliferationDifferential responsivenessRecent studiesBromodeoxyuridine uptakeDifferential modulationOrganotypic slice culturesClassical neurotransmitters GABAOpposite effectNeurotransmitter GABARelative contributionClonesDisparate effectsRegulationSlice culturesSpecific GABA
1997
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
Yang D, Kuan C, Whitmarsh A, Rinócn M, Zheng T, Davis R, Rakic P, Flavell R. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 1997, 389: 865-870. PMID: 9349820, DOI: 10.1038/39899.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisDrug ResistanceExcitatory Amino Acid AgonistsGene ExpressionGene TargetingGlutamic AcidHippocampusKainic AcidMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 10Mitogen-Activated Protein KinasesNeuronsPhosphorylationProtein KinasesProtein Serine-Threonine KinasesProtein-Tyrosine KinasesProto-Oncogene Proteins c-fosProto-Oncogene Proteins c-junSeizuresSignal TransductionTranscription Factor AP-1ConceptsKainic acidGlutamate receptor agonist kainic acidAgonist kainic acidExcitotoxicity-induced apoptosisExcitatory amino acidsHippocampal neuron apoptosisHippocampus of miceStress-induced neuronal apoptosisObserved neuroprotectionGlutamate neurotoxicitySeizure activityNeuron apoptosisGlutamate toxicityNeuronal apoptosisAP-1 transcription factor complexJNK3 geneMutant miceMiceMembrane depolarizationNoxious stressTranscription factor complexApoptosisC-JunRecent studiesTranscriptional activity
1993
Modulation of Neuronal Migration by NMDA Receptors
Komuro H, Rakic P. Modulation of Neuronal Migration by NMDA Receptors. Science 1993, 260: 95-97. PMID: 8096653, DOI: 10.1126/science.8096653.Peer-Reviewed Original ResearchConceptsNMDA receptorsN-methyl-D-aspartate (NMDA) subtypeEndogenous extracellular glutamateCell migrationNMDA receptor activityElimination of synapsesApplication of glycineSynaptic contactsSlice preparationExtracellular glutamateGlutamate receptorsSpecific antagonistGranule cellsReceptor activityNeuronal migrationNeuronal differentiationReceptorsMouse cerebellumEarly roleBlockadeAntagonistCerebellumSubtypesNeuronsBrain