2023
Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon
Micali N, Ma S, Li M, Kim S, Mato-Blanco X, Sindhu S, Arellano J, Gao T, Shibata M, Gobeske K, Duque A, Santpere G, Sestan N, Rakic P. Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon. Science 2023, 382: eadf3786. PMID: 37824652, PMCID: PMC10705812, DOI: 10.1126/science.adf3786.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain NeoplasmsFemaleGalanin-Like PeptideGene Expression Regulation, DevelopmentalMacacaMental DisordersNervous System DiseasesNeural Stem CellsNeurogenesisNeuronsPregnancyTelencephalon
2009
Evolution of the neocortex: a perspective from developmental biology
Rakic P. Evolution of the neocortex: a perspective from developmental biology. Nature Reviews Neuroscience 2009, 10: 724-735. PMID: 19763105, PMCID: PMC2913577, DOI: 10.1038/nrn2719.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsBiological EvolutionDevelopmental BiologyGene Expression Regulation, DevelopmentalHumansModels, BiologicalNeocortexNeuronsSpecies SpecificityConceptsEvo-devo approachSpecies-specific adaptationsExtinct common ancestorsNew cell typesSpecies-specific differencesMutations of genesProliferative ventricular zoneMammalian evolutionDistinct migratory pathwaysCommon ancestorDevelopmental biologyCell divisionNew traitsNew cell subtypesNeural stem cellsProtomap hypothesisMouse embryosNew cytoarchitectonic areasTranscriptional factorsUnique cognitive abilitiesGene expressionDifferential enlargementDistinct traitsMigratory pathwaysCortical evolutionDecision by division: making cortical maps
Rakic P, Ayoub AE, Breunig JJ, Dominguez MH. Decision by division: making cortical maps. Trends In Neurosciences 2009, 32: 291-301. PMID: 19380167, PMCID: PMC3601545, DOI: 10.1016/j.tins.2009.01.007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody PatterningBrain MappingCell MovementCerebral CortexGene Expression Regulation, DevelopmentalHumansModels, NeurologicalNeural PathwaysNeurogenesisNeuronal PlasticityNeuronsConceptsNeuronal fate determinationFate determinationFinal mitotic divisionEvolutionary expansionCell determinationMitotic divisionProtomap hypothesisEarly specificationLatest compendiumBiological basisProliferative zoneNeuronal classesNewborn neuronsBroad spectrumDivisionGenesHuman neocortexCortical malformationsNeuronsRadial unitsCompendiumMigrationCerebral wall
2001
Independent parcellation of the embryonic visual cortex and thalamus revealed by combinatorial Eph/ephrin gene expression
Šestan N, Rakic P, Donoghue M. Independent parcellation of the embryonic visual cortex and thalamus revealed by combinatorial Eph/ephrin gene expression. Current Biology 2001, 11: 39-43. PMID: 11166178, DOI: 10.1016/s0960-9822(00)00043-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGene Expression Regulation, DevelopmentalMacacaNerve Tissue ProteinsReceptor Protein-Tyrosine KinasesThalamusVisual CortexConceptsVisual cortical areasVisual cortexCortical plateCortical areasReciprocal connectionsDistinct visual cortical areasLateral geniculate nucleusEphA family membersPulvinar projectionsHigher association areasCytoarchitectonic differentiationThalamic nucleiGeniculate nucleusThalamusAssociation areasThalamocortical systemRhesus monkeysExtrastriate cortexCortexReceptor tyrosine kinasesEph receptor tyrosine kinasesMolecular patternsFamily membersTyrosine kinaseStriate
1999
Genetic Control of Cortical Development
Rubenstein J, Rakic P. Genetic Control of Cortical Development. Cerebral Cortex 1999, 9: 521-523. PMID: 10498269, DOI: 10.1093/cercor/9.6.521.Peer-Reviewed Original ResearchMolecular Gradients and Compartments in the Embryonic Primate Cerebral Cortex
Donoghue M, Rakic P. Molecular Gradients and Compartments in the Embryonic Primate Cerebral Cortex. Cerebral Cortex 1999, 9: 586-600. PMID: 10498277, DOI: 10.1093/cercor/9.6.586.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntisense Elements (Genetics)Brain ChemistryCloning, MolecularDNA-Binding ProteinsEphrin-A1FemaleGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicHomeodomain ProteinsIn Situ HybridizationMacaca mulattaNeocortexNeuronsPregnancyProsencephalonProteinsReceptor Protein-Tyrosine KinasesTranscription FactorsConceptsCerebral cortexPrimate cerebral cortexEmbryonic cerebral cortexMature cerebral cortexEphA receptor tyrosine kinasesArrival of afferentsPrimate forebrainCortical plateMature cortexEfferent connectionsCortical developmentCortical areasAnteroposterior extentSpecific afferentsMacaque monkeysReceptor tyrosine kinasesPeripheral influencesCortexGene expressionPrimate corticogenesisAfferentsNeocortexIntrinsic programCorticogenesisTyrosine kinaseMolecular Evidence for the Early Specification of Presumptive Functional Domains in the Embryonic Primate Cerebral Cortex
Donoghue M, Rakic P. Molecular Evidence for the Early Specification of Presumptive Functional Domains in the Embryonic Primate Cerebral Cortex. Journal Of Neuroscience 1999, 19: 5967-5979. PMID: 10407035, PMCID: PMC6783094, DOI: 10.1523/jneurosci.19-14-05967.1999.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral CortexEmbryonic and Fetal DevelopmentGene Expression Regulation, DevelopmentalGestational AgeHumansIn Situ HybridizationMacaca mulattaNerve Tissue ProteinsOrgan SpecificityReceptor Protein-Tyrosine KinasesConceptsCortical platePresumptive visual cortexPrimate cerebral cortexLigand ephrin-A5Appropriate synaptic connectionsCortical cellsThalamocortical connectionsCerebral cortexMonkey neocortexCortical developmentPrimate neocortexVisual cortexSynaptic connectionsEphrin-A3Ephrin-A2Extrastriate cortexEarly gene expressionEmbryonic neocortexEphrin-A5Molecular patternsNeocortexCortexEphA6Primate corticogenesisPosterior regionThe Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development
Kuan C, Yang D, Roy D, Davis R, Rakic P, Flavell R. The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development. Neuron 1999, 22: 667-676. PMID: 10230788, DOI: 10.1016/s0896-6273(00)80727-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBrainCalcium-Calmodulin-Dependent Protein KinasesCaspasesEmbryonic and Fetal DevelopmentEnzyme ActivationGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicJNK Mitogen-Activated Protein KinasesMiceMice, KnockoutMitogen-Activated Protein Kinase 9Mitogen-Activated Protein KinasesNervous SystemProtein KinasesRhombencephalonConceptsNeural tube closureBrain developmentEmbryonic lethalDouble mutantKinase familyCompound mutantsProtein kinaseCaspase activationPrecocious degenerationJNK2 geneTube closureEarly brain developmentCell deathJNK1Different membersSpecific apoptosisApoptosisMutantsMutant miceJNK2JNK3Mutant forebrainSevere dysregulationFamilyKinaseIllusive transience of parvalbumin expression duringembryonic development of the primate spinal cord
Knyihár‐csillik E, Rakic P, Csillik B. Illusive transience of parvalbumin expression duringembryonic development of the primate spinal cord. International Journal Of Developmental Neuroscience 1999, 17: 79-97. PMID: 10221668, DOI: 10.1016/s0736-5748(98)00090-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonal TransportCalcium SignalingFetal ProteinsGanglia, SpinalGene Expression Regulation, DevelopmentalGestational AgeMacaca fascicularisMicroscopy, ElectronNerve EndingsNerve Tissue ProteinsNeurons, AfferentParvalbuminsSpinal CordConceptsNerve cellsSpinal cordLarge dorsal root ganglion cellsDorsal root ganglion cellsYoung adult macaque monkeysPrimate spinal cordUpper dorsal hornDorsal root axonsPrimary sensory neuronsSpinal reflex pathwaysElectron microscopic immunohistochemical techniquesAdult macaque monkeysParvalbumin-positive terminalsLong axonal processesDorsal hornMonkey fetusesDorsal columnsReflex pathwaysGanglion cellsClarke's nucleusAxon terminalsIntercellular networkMotoneuron poolSensory neuronsSynaptic terminals
1998
Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9
Kuida K, Haydar T, Kuan C, Gu Y, Taya C, Karasuyama H, Su M, Rakic P, Flavell R. Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9. Cell 1998, 94: 325-337. PMID: 9708735, DOI: 10.1016/s0092-8674(00)81476-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBrainCaspase 3Caspase 9CaspasesCysteine EndopeptidasesCytochrome c GroupEnzyme ActivationGene Expression Regulation, DevelopmentalHumansHydrolysisMiceMice, KnockoutSequence DeletionThymus GlandT-LymphocytesConceptsCritical upstream activatorUpstream activatorCaspase-9Cell death machineryCytochrome cDeath machineryApoptotic stimuliCaspase activationCaspase cascadeDNA fragmentationPrevents activationCytosolic extractsEmbryonic brainCaspasesReduced apoptosisCASP9ApoptosisActivatorCASP3Brain developmentKnockout miceEssential componentCleavageActivationVivo
1995
Distribution and density of monoamine receptors in the primate visual cortex devoid of retinal input from early embryonic stages
Rakic P, Lidow. Distribution and density of monoamine receptors in the primate visual cortex devoid of retinal input from early embryonic stages. Journal Of Neuroscience 1995, 15: 2561-2574. PMID: 7891189, PMCID: PMC6578103, DOI: 10.1523/jneurosci.15-03-02561.1995.Peer-Reviewed Original ResearchConceptsMonoamine receptorsVisual cortexLaminar distributionSpecific laminar patternMonths of agePrimate visual cortexGroups of animalsBinocular enucleationCortical consequencesPrestriate areasCerebral cortexMonoaminergic receptorsSupragranular layersCortical plateLayer IVCongenital anophthalmiaGeniculocortical fibersOccipital lobeCortical bindingLaminar patternRetinal inputNeurotransmitter receptorsMonkey striateCoronal planeDistinct laminar