2014
Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia
Brennand K, Savas J, Kim Y, Tran N, Simone A, Hashimoto-Torii K, Beaumont K, Kim H, Topol A, Ladran I, Abdelrahim M, Matikainen-Ankney B, Chao S, Mrksich M, Rakic P, Fang G, Zhang B, Yates J, Gage F. Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. Molecular Psychiatry 2014, 20: 361-368. PMID: 24686136, PMCID: PMC4182344, DOI: 10.1038/mp.2014.22.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntipsychotic AgentsCell DifferentiationCell MovementCells, CulturedFemaleGene ExpressionHumansMaleMiceMice, Inbred C57BLMice, TransgenicMitochondriaNeural Cell Adhesion MoleculesNeural Stem CellsOxidative StressPhenotypePluripotent Stem CellsProsencephalonProteomicsReactive Oxygen SpeciesSchizophreniaYoung AdultConceptsHiPSC neural progenitor cellsNeural progenitor cellsHuman-induced pluripotent stem cellsHiPSC-derived neuronsGene expressionGene expression comparisonsStable isotope labelingProteomic mass spectrometry analysisAbnormal gene expressionPluripotent stem cellsOxidative stressCytoskeletal remodelingMass spectrometry analysisCellular phenotypesExpression comparisonsDevelopmental mechanismsIsotope labelingPhenotypic differencesBrainSpan AtlasDisease predispositionAmino acidsScalable assayNPC phenotypeStem cellsProgenitor cells
2001
The generation, migration, and differentiation of olfactory neurons in the adult primate brain
Kornack D, Rakic P. The generation, migration, and differentiation of olfactory neurons in the adult primate brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 4752-4757. PMID: 11296302, PMCID: PMC31906, DOI: 10.1073/pnas.081074998.Peer-Reviewed Original ResearchConceptsRostral migratory streamOlfactory bulbAdult primate brainAdult macaque monkeysNeural progenitor cellsSmaller olfactory bulbsAdult rodentsSubependymal zoneImmunohistochemical detectionPrimate brainMacaque monkeysOlfactory neuronsMigratory streamNonhuman primatesProgenitor cellsRegenerative mechanismsInterneuronsHuman brainBrainNeuroblastsCellsNeurons