2002
Notch Signaling in the Brain: More than Just a Developmental Story
Šestan N, Rakic P. Notch Signaling in the Brain: More than Just a Developmental Story. Research And Perspectives In Alzheimer's Disease 2002, 19-40. DOI: 10.1007/978-3-642-55996-9_2.Peer-Reviewed Original ResearchNotch signalingNeural developmentCell-cell interaction mechanismCell fate acquisitionCell fate decisionsEarly neural developmentDifferent signaling mechanismsVariety of speciesFate acquisitionNotch signalsCellular phenotypesNotch pathwayMolecular mechanismsSignaling mechanismApoptotic cuesNeuronal differentiationMolecular processesNervous systemAlzheimer's diseaseAdult-onset neurological disordersNeural cellsImportant playersSignalingNeurodegenerative disordersLife span
1999
Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling
Šestan N, Artavanis-Tsakonas S, Rakic P. Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling. Science 1999, 286: 741-746. PMID: 10531053, DOI: 10.1126/science.286.5440.741.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CommunicationCell CountCell DifferentiationCell MovementCell NucleusCell SizeCells, CulturedCerebral CortexContact InhibitionHumansLigandsMembrane ProteinsMiceMitosisNeuritesNeuronsProtein Structure, TertiaryReceptor, Notch1Receptor, Notch2Receptors, Cell SurfaceSignal TransductionTranscription FactorsTranscriptional ActivationUp-RegulationConceptsNeurite growthMouse cerebral cortexCapacity of neuronsCortical neurite growthStudy of neuronsInhibition of NotchCerebral cortexNotch signalingCortical neuronsNotch activityMature neuronsInterneuronal contactsRetraction of neuritesHigh Notch activityNeuronsNeuronal growthNeuritesContact-dependent inhibitionExuberant growthNeurite extensionNotch receptorsInhibitionLow Notch activitySignalingActivityProcessing of the Notch Ligand Delta by the Metalloprotease Kuzbanian
Qi H, Rand M, Wu X, Sestan N, Wang W, Rakic P, Xu T, Artavanis-Tsakonas S. Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian. Science 1999, 283: 91-94. PMID: 9872749, DOI: 10.1126/science.283.5398.91.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell LineCells, CulturedDisintegrinsDrosophilaDrosophila ProteinsFemaleIntracellular Signaling Peptides and ProteinsLigandsMaleMembrane ProteinsMetalloendopeptidasesMolecular Sequence DataMutationNeuronsProtein Processing, Post-TranslationalReceptors, NotchSignal TransductionTransfectionConceptsLigand DeltaMetalloprotease KuzbanianCell fate determinationNotch ligand DeltaFate determinationNotch proteinsTransmembrane ligandsNotch activityProcessing eventsExtracellular fragmentGenetic analysisNotch ligandsSurface receptorsKuzbanianAdjacent cellsSoluble formBroad spectrumNotchSignalingProteinLigandsCellsFragmentsVivoReceptors
1994
Recognition, adhesion, transmembrane signaling and cell motility in guided neuronal migration
Rakic P, Cameron R, Komuro H. Recognition, adhesion, transmembrane signaling and cell motility in guided neuronal migration. Current Opinion In Neurobiology 1994, 4: 63-69. PMID: 8173327, DOI: 10.1016/0959-4388(94)90033-7.Peer-Reviewed Original ResearchConceptsCell motilityDiverse cellular mechanismsMultiple molecular eventsSpecific ion channelsTransmembrane signalingExtracellular substratesMigration of neuronsMolecular eventsSecond messengerMolecular componentsIndividual molecular componentsIon channelsCellular mechanismsNeuronal migrationRecognition receptorsAdhesive interactionsAdhesion moleculesMultiple adhesion moleculesFinal destinationRecent studiesMotilityReceptorsSignalingMessengerMigration