2024
Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders
Datta D, Yang S, Joyce M, Woo E, McCarroll S, Gonzalez-Burgos G, Perone I, Uchendu S, Ling E, Goldman M, Berretta S, Murray J, Morozov Y, Arellano J, Duque A, Rakic P, O’Dell R, van Dyck C, Lewis D, Wang M, Krienen F, Arnsten A. Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders. JAMA Psychiatry 2024, 81: 870-881. PMID: 38776078, PMCID: PMC11112502, DOI: 10.1001/jamapsychiatry.2024.1112.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexLayer III pyramidal cellsWorking memoryCognitive disordersNeuronal firingPrimate dorsolateral prefrontal cortexPyramidal cellsSpatial working memoryWorking memory performanceRisk of mental disordersCalcium-related proteinsReduced neuronal firingL-type calcium channel Cav1.2GluN2B-NMDA receptorsL-type calcium channel activityPrefrontal neuronsL-type calcium channel blockerMemory performanceL-type calcium channelsMental disordersRisk of cognitive disordersCognitive behaviorProtein expressionAssociated with increased risk
1988
CCK-immunoreactive terminals form different types of synapses in the rat and monkey hippocampus
Leranth C, Frotscher M, Rakic P. CCK-immunoreactive terminals form different types of synapses in the rat and monkey hippocampus. Histochemistry And Cell Biology 1988, 88: 343-352. PMID: 3366638, DOI: 10.1007/bf00570293.Peer-Reviewed Original ResearchConceptsSynaptic contactsMonkey hippocampusSymmetric synaptic contactsAsymmetric synaptic contactsDistribution of CCKExcitatory transmissionSymmetric synapsesDendritic shaftsPyramidal cellsRat hippocampusCA3 regionDendritic spinesPrimate hippocampusHippocampusCell bodiesRodent hippocampusSame neuropeptidesImmunocytochemical analysisPresent findingsRatsSynapsesImportant differencesAsymmetric contactsCholecystokininCA1
1981
The genesis of efferent connections from the visual cortex of the fetal rhesus monkey
Shatz C, Rakic P. The genesis of efferent connections from the visual cortex of the fetal rhesus monkey. The Journal Of Comparative Neurology 1981, 196: 287-307. PMID: 7217358, DOI: 10.1002/cne.901960208.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusInfragranular cortical layersFetal rhesus monkeysSuperior colliculusRhesus monkeysCortical projectionsPyramidal neuronsVisual cortexCortical layersSubcortical structuresDorsal lateral geniculate nucleusTopographic orderCell-poor zoneCorticogeniculate projectionsSuperficial grayAfferent pathwaysCortical efferentsCortical injectionsEfferent pathwaysCortical plateDendritic arborizationArea 17Pyramidal cellsEfferent connectionsGeniculate nucleusThe time of origin of neurons in the hippocampal region of the rhesus monkey
Rakic P, Nowakowski R. The time of origin of neurons in the hippocampal region of the rhesus monkey. The Journal Of Comparative Neurology 1981, 196: 99-128. PMID: 7204668, DOI: 10.1002/cne.901960109.Peer-Reviewed Original ResearchConceptsHippocampal regionArea CA2Entorhinal areaArea CA1Fascia dentataGranule cellsRhesus monkeysFirst postnatal monthProduction of neuronsEmbryonic day 33Parasubicular neuronsHippocampal neurogenesisDentate gyrusArea CA4Stratum pyramidalePyramidal cellsPostnatal monthArea CA3Last neuronsHippocampal subdivisionsCell originParahippocampal formationHistological dataDay 33Neurons