2024
Correlation between the number of interstitial neurons of the white matter and number of neurons within cortical layers: Histological analyses in postnatal macaque
Ahmed B, Duque A, Rakic P, Molnár Z. Correlation between the number of interstitial neurons of the white matter and number of neurons within cortical layers: Histological analyses in postnatal macaque. The Journal Of Comparative Neurology 2024, 532: e25626. PMID: 39031698, PMCID: PMC11262481, DOI: 10.1002/cne.25626.Peer-Reviewed Original ResearchWhite matter interstitial cellsInterstitial neuronsLayer 5Macaque cortexCortical neuronsGyral crownsInterstitial cellsStandardized cell numbersCell numberSulcal regionsDensity of neuronsLinear regionCortical layer thicknessLayer thicknessOverlying cortexCoronal sectionsHistological analysisDensityWhite matterNeuronsLayerCortical layersClinical perspectiveThicknessCortical thicknessModelling adult neurogenesis in the aging rodent hippocampus: a midlife crisis
Arellano J, Rakic P. Modelling adult neurogenesis in the aging rodent hippocampus: a midlife crisis. Frontiers In Neuroscience 2024, 18: 1416460. PMID: 38887368, PMCID: PMC11181911, DOI: 10.3389/fnins.2024.1416460.Peer-Reviewed Original ResearchAdult neurogenesisHippocampal functionAdult hippocampal neurogenesisAged animalsMiddle aged animalsHippocampal neurogenesisGranule cellsDentate gyrusMature granule cellsRodent hippocampusMidlife crisisNeurogenesisFunctional relevanceRodentsDramatically with ageNeuronsYoung animalsOlder animalsGyrusHippocampusRatsRobust neurogenesisHippocampalMeta-analysisDentate
2023
Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease
Datta D, Perone I, Morozov Y, Arellano J, Duque A, Rakic P, van Dyck C, Arnsten A. Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease. Cerebral Cortex 2023, 33: 11501-11516. PMID: 37874022, PMCID: PMC10724870, DOI: 10.1093/cercor/bhad382.Peer-Reviewed Original ResearchConceptsHCN1 channelsTau pathologyGlutamate synapsesEntorhinal cortexCalcium actionInternal calcium releaseEntorhinal cortex stellate cellsDorsolateral prefrontal cortexSusceptible neuronsInitial pathologySelective vulnerabilityEtiological factorsTau phosphorylationStellate cellsAlzheimer's diseaseSpecific neuronsCalcium releasePrefrontal cortexCortexSynapse strengthPathologyCalcium signalingCalbindinDiseaseNeurons
2009
Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling
Torii M, Hashimoto-Torii K, Levitt P, Rakic P. Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling. Nature 2009, 461: 524-528. PMID: 19759535, PMCID: PMC2874978, DOI: 10.1038/nature08362.Peer-Reviewed Original ResearchConceptsNeocortical excitatory neuronsRadial glial fibersColumnar organizationEphA/ephrinCerebral cortexFunctional impairmentNeuronal clonesExcitatory neuronsGlial fibersTangential migrationCortical columnsNeural progenitorsCircuit developmentEphrinProliferative unitsPopulationClonal populationsCortexNeuronsSelective reduction of neuron number and volume of the mediodorsal nucleus of the thalamus in macaques following irradiation at early gestational ages
Selemon LD, Begović A, Rakic P. Selective reduction of neuron number and volume of the mediodorsal nucleus of the thalamus in macaques following irradiation at early gestational ages. The Journal Of Comparative Neurology 2009, 515: 454-464. PMID: 19459221, PMCID: PMC2716797, DOI: 10.1002/cne.22078.Peer-Reviewed Original ResearchDecision by division: making cortical maps
Rakic P, Ayoub AE, Breunig JJ, Dominguez MH. Decision by division: making cortical maps. Trends In Neurosciences 2009, 32: 291-301. PMID: 19380167, PMCID: PMC3601545, DOI: 10.1016/j.tins.2009.01.007.Peer-Reviewed Original ResearchConceptsNeuronal fate determinationFate determinationFinal mitotic divisionEvolutionary expansionCell determinationMitotic divisionProtomap hypothesisEarly specificationLatest compendiumBiological basisProliferative zoneNeuronal classesNewborn neuronsBroad spectrumDivisionGenesHuman neocortexCortical malformationsNeuronsRadial unitsCompendiumMigrationCerebral wall
2005
Intrinsic and Extrinsic Determinants of Neocortical Parcellation: A Radial Unit Model
Rakic P. Intrinsic and Extrinsic Determinants of Neocortical Parcellation: A Radial Unit Model. 2005, 83-100. DOI: 10.1002/9780470753507.ch6.Peer-Reviewed Original Research
2002
Pre- and post-developmental neurogenesis in primates
Rakic P. Pre- and post-developmental neurogenesis in primates. Clinical Neuroscience Research 2002, 2: 29-39. DOI: 10.1016/s1566-2772(02)00005-1.Peer-Reviewed Original ResearchPrimate brainMonkey central nervous systemAdult primate brainClasses of neuronsCentral nervous systemForm of therapyCerebral cortexMost neuronsDentate gyrusCompetent neuronsOlfactory bulbNervous systemBromodeoxyuridine methodNeuronal classesDevelopmental periodSpecific developmental periodsNeuronsCell classesNeurogenesisBrainLower ratesEntire life spanLife spanRegional differencesTherapy
2001
Cell Proliferation Without Neurogenesis in Adult Primate Neocortex
Kornack D, Rakic P. Cell Proliferation Without Neurogenesis in Adult Primate Neocortex. Science 2001, 294: 2127-2130. PMID: 11739948, DOI: 10.1126/science.1065467.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBrainBromodeoxyuridineCell DeathCell DivisionCell MovementEndothelium, VascularFemaleFluorescent Antibody TechniqueGlial Fibrillary Acidic ProteinImmunoenzyme TechniquesMacaca fascicularisMacaca mulattaMaleMicroscopy, ConfocalMicroscopy, FluorescenceNeocortexNeuronsNuclear ProteinsTubulinConceptsPrimate neocortexGlial cell markersAdult macaque monkeysNew neuronsNumerous BrdUOlfactory bulbCerebral wallAdult macaquesMacaque monkeysNonneuronal cellsHigher cognitive functionsCell markersCognitive functionNeocortexNeurogenesisTriple labelingCellular mechanismsCell proliferationNeuronsCellsHippocampusTelencephalic origin of human thalamic GABAergic neurons
Letinic K, Rakic P. Telencephalic origin of human thalamic GABAergic neurons. Nature Neuroscience 2001, 4: 931-936. PMID: 11528425, DOI: 10.1038/nn0901-931.Peer-Reviewed Original ResearchConceptsNon-primate mammalian speciesHomeodomain-containing proteinMigratory pathwaysThalamic association nucleiVital dye labelingEvolutionary expansionMammalian speciesAssociation nucleiTelencephalic cellsRodent embryosGuidance cuesChemorepulsive cuesMigration assaysOrganotypic slice culturesDye labelingProliferative zoneNon-human primatesGABAergic neuronsDiencephalic neuronsPathwayDorsal thalamusTelencephalic originGanglionic eminenceSlice culturesNeuronsDevelopment of Layer I Neurons in the Primate Cerebral Cortex
Zecevic N, Rakic P. Development of Layer I Neurons in the Primate Cerebral Cortex. Journal Of Neuroscience 2001, 21: 5607-5619. PMID: 11466432, PMCID: PMC6762645, DOI: 10.1523/jneurosci.21-15-05607.2001.Peer-Reviewed Original ResearchConceptsCerebral cortexLayer ILayer I cellsLayer I neuronsPrimate cerebral cortexCajal-Retzius cellsSubpial granular layerGABAergic neuronsGABAergic interneuronsCortical plateI neuronsGanglionic eminenceMacaque monkeysPial surfaceOlfactory primordiumI cellsNeuronsMonth periodLong gestationGranular layerCortexUltrastructural analysisCorticogenesisCellsPrimatesThe generation, migration, and differentiation of olfactory neurons in the adult primate brain
Kornack D, Rakic P. The generation, migration, and differentiation of olfactory neurons in the adult primate brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 4752-4757. PMID: 11296302, PMCID: PMC31906, DOI: 10.1073/pnas.081074998.Peer-Reviewed Original ResearchConceptsRostral migratory streamOlfactory bulbAdult primate brainAdult macaque monkeysNeural progenitor cellsSmaller olfactory bulbsAdult rodentsSubependymal zoneImmunohistochemical detectionPrimate brainMacaque monkeysOlfactory neuronsMigratory streamNonhuman primatesProgenitor cellsRegenerative mechanismsInterneuronsHuman brainBrainNeuroblastsCellsNeuronsNormal Programmed Cell Death of Developing Avian and Mammalian Neurons Following Inhibition or Genetic Deletion of Caspases
Oppenheim R, Kuan C, Prevette D, Rakic P, Yaginuma H. Normal Programmed Cell Death of Developing Avian and Mammalian Neurons Following Inhibition or Genetic Deletion of Caspases. Research And Perspectives In Neurosciences 2001, 61-74. DOI: 10.1007/978-3-662-04333-2_6.Peer-Reviewed Original ResearchCell deathAbsence of caspasesProgrammed Cell DeathCaspase family membersPost-mitotic neuronsGenetic deletionCaspase inhibitorsCaspase activityNeuronal PCDMammalian neuronsPCDCaspasesChick embryosDeletionFamily membersMorphological degenerationEmbryosUpstreamNeuronsNormal occurrenceInhibitorsOvoInhibitionMembersDeath
1999
Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling
Šestan N, Artavanis-Tsakonas S, Rakic P. Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling. Science 1999, 286: 741-746. PMID: 10531053, DOI: 10.1126/science.286.5440.741.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CommunicationCell CountCell DifferentiationCell MovementCell NucleusCell SizeCells, CulturedCerebral CortexContact InhibitionHumansLigandsMembrane ProteinsMiceMitosisNeuritesNeuronsProtein Structure, TertiaryReceptor, Notch1Receptor, Notch2Receptors, Cell SurfaceSignal TransductionTranscription FactorsTranscriptional ActivationUp-RegulationConceptsNeurite growthMouse cerebral cortexCapacity of neuronsCortical neurite growthStudy of neuronsInhibition of NotchCerebral cortexNotch signalingCortical neuronsNotch activityMature neuronsInterneuronal contactsRetraction of neuritesHigh Notch activityNeuronsNeuronal growthNeuritesContact-dependent inhibitionExuberant growthNeurite extensionNotch receptorsInhibitionLow Notch activitySignalingActivityDiscriminating migrations
Rakic P. Discriminating migrations. Nature 1999, 400: 315-316. PMID: 10432106, DOI: 10.1038/22427.Peer-Reviewed Original ResearchDistinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex
Anton E, Kreidberg J, Rakic P. Distinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex. Neuron 1999, 22: 277-289. PMID: 10069334, DOI: 10.1016/s0896-6273(00)81089-2.Peer-Reviewed Original ResearchConceptsCerebral cortexNeuronal migrationNeuron-glial interactionsΑv integrin receptorsRadial glial cellsRadial glial fibersCortical neuronsGlial cellsAbnormal layeringLaminar organizationGlial fibersCortexNeuronsSpecific cell-cell recognitionAlpha3beta1 integrinIntegrin receptorsIntegrin geneIntegrinsTargeted mutationsIntegrin functionCorticogenesisReceptors
1998
Young neurons for old brains?
Rakic P. Young neurons for old brains? Nature Neuroscience 1998, 1: 645-647. PMID: 10196576, DOI: 10.1038/3643.Peer-Reviewed Original ResearchDistinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex
Komuro H, Rakic P. Distinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex. Journal Of Neuroscience 1998, 18: 1478-1490. PMID: 9454856, PMCID: PMC6792738, DOI: 10.1523/jneurosci.18-04-01478.1998.Peer-Reviewed Original ResearchConceptsGranule cellsInternal granular layerBergmann glial fibersGlial fibersMost granule cellsMossy fiber terminalsLocal environmental cuesPurkinje cell layerGranular layerAcute cerebellar slice preparationCerebellar slice preparationSynaptic contactsGranule cell movementSlice preparationFiber terminalsBergmann gliaCerebellar cortexPostmitotic neuronsNeuronal migrationNeuronsSomaCell layerCerebellar neurogenesisPresent studyDifferent cellular microenvironments
1997
Developmental expression, pattern of distribution, and effect on cell aggregation implicate a neuron‐glial junctional domain protein in neuronal migration
Cameron R, Ruffin J, Cho N, Cameron P, Rakic P. Developmental expression, pattern of distribution, and effect on cell aggregation implicate a neuron‐glial junctional domain protein in neuronal migration. The Journal Of Comparative Neurology 1997, 387: 467-488. PMID: 9373008, DOI: 10.1002/(sici)1096-9861(19971103)387:4<467::aid-cne1>3.0.co;2-0.Peer-Reviewed Original ResearchConceptsRadial glial cellsGlial cellsRadial glial cell processesGlial cell processesMultiple brain regionsNeuronal cell migrationAstrocyte-astrocyteSubventricular zoneImmunofluorescent localization studiesAstroglial cellsNeuron-neuronCerebellar astrocytesBrain regionsMorphologic featuresNeuronal migrationMonoclonal antibodiesImmunoreactivityAntibodiesNeuronsAstrocytesCell migrationPresent studyDevelopmental expressionPattern of distributionCell migration processesRole of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex.
Anton E, Marchionni M, Lee K, Rakic P. Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex. Development 1997, 124: 3501-10. PMID: 9342043, DOI: 10.1242/dev.124.18.3501.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCell CommunicationCell MovementCerebral CortexCulture TechniquesFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsGlycoproteinsNerve Growth FactorsNerve Tissue ProteinsNeuregulinsNeurogliaNeuronsRatsRats, Sprague-DawleyReceptor, ErbB-2Receptors, Nerve Growth FactorSignal TransductionConceptsRadial glial developmentRadial glial cellsBrain lipid-binding proteinCerebral cortexGlial cellsNeuronal migrationGlial developmentRadial glial cell functionGlial growth factorGlial cell functionRadial glial fibersRadial glial fiber systemNeuronal cell migrationCortical neuronsGlial interactionsRadial gliaGlial fibersGlial moleculesCortexNeuronsGrowth factorErbB2 receptorCell functionDependent mannerCell migration