2024
Modelling adult neurogenesis in the aging rodent hippocampus: a midlife crisis
Arellano J, Rakic P. Modelling adult neurogenesis in the aging rodent hippocampus: a midlife crisis. Frontiers In Neuroscience 2024, 18: 1416460. PMID: 38887368, PMCID: PMC11181911, DOI: 10.3389/fnins.2024.1416460.Peer-Reviewed Original ResearchAdult neurogenesisHippocampal functionAdult hippocampal neurogenesisAged animalsMiddle aged animalsHippocampal neurogenesisGranule cellsDentate gyrusMature granule cellsRodent hippocampusMidlife crisisNeurogenesisFunctional relevanceRodentsDramatically with ageNeuronsYoung animalsOlder animalsGyrusHippocampusRatsRobust neurogenesisHippocampalMeta-analysisDentate
1998
Orchestration of neuronal migration by activity of ion channels, neurotransmitter receptors, and intracellular Ca2+ fluctuations
Komuro H, Rakic P. Orchestration of neuronal migration by activity of ion channels, neurotransmitter receptors, and intracellular Ca2+ fluctuations. Developmental Neurobiology 1998, 37: 110-130. PMID: 9777736, DOI: 10.1002/(sici)1097-4695(199810)37:1<110::aid-neu9>3.0.co;2-c.Peer-Reviewed Original ResearchConceptsGranule cellsNeurotransmitter receptorsGranule cell movementN-methyl-D-aspartate (NMDA) subtypeN-type Ca2Different cortical layersIon channelsAcute cerebellar slicesFrequency of Ca2Local cellular milieuPhase of Ca2Position-specific changesVoltage-gated ion channelsGlutamate receptorsSpecific ion channelsCerebellar slicesIntracellular Ca2Transient Ca2Cortical layersReceptor activityNeuronal migrationReceptorsPlasmalemmal surfaceLocal environmental cuesCell migrationDistinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex
Komuro H, Rakic P. Distinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex. Journal Of Neuroscience 1998, 18: 1478-1490. PMID: 9454856, PMCID: PMC6792738, DOI: 10.1523/jneurosci.18-04-01478.1998.Peer-Reviewed Original ResearchConceptsGranule cellsInternal granular layerBergmann glial fibersGlial fibersMost granule cellsMossy fiber terminalsLocal environmental cuesPurkinje cell layerGranular layerAcute cerebellar slice preparationCerebellar slice preparationSynaptic contactsGranule cell movementSlice preparationFiber terminalsBergmann gliaCerebellar cortexPostmitotic neuronsNeuronal migrationNeuronsSomaCell layerCerebellar neurogenesisPresent studyDifferent cellular microenvironments
1995
Dynamics of granule cell migration: a confocal microscopic study in acute cerebellar slice preparations
Komuro H, Rakic P. Dynamics of granule cell migration: a confocal microscopic study in acute cerebellar slice preparations. Journal Of Neuroscience 1995, 15: 1110-1120. PMID: 7869087, PMCID: PMC6577849, DOI: 10.1523/jneurosci.15-02-01110.1995.Peer-Reviewed Original ResearchConceptsCell movementCell migrationPlasma membraneShort stationary phaseCerebellar slice preparationGranule cell migrationMolecular mechanismsMembrane flowConfocal microscopic studiesIndividual cellsNeuronal migrationConfocal microscopyCytological aspectsDil crystalsCellsMembraneBergmann glial fibersGranule cellsMigrationMicrons/hrOld micePostnatal lifeConsiderable variationAcute cerebellar slice preparationStationary phase
1993
Modulation of Neuronal Migration by NMDA Receptors
Komuro H, Rakic P. Modulation of Neuronal Migration by NMDA Receptors. Science 1993, 260: 95-97. PMID: 8096653, DOI: 10.1126/science.8096653.Peer-Reviewed Original ResearchConceptsNMDA receptorsN-methyl-D-aspartate (NMDA) subtypeEndogenous extracellular glutamateCell migrationNMDA receptor activityElimination of synapsesApplication of glycineSynaptic contactsSlice preparationExtracellular glutamateGlutamate receptorsSpecific antagonistGranule cellsReceptor activityNeuronal migrationNeuronal differentiationReceptorsMouse cerebellumEarly roleBlockadeAntagonistCerebellumSubtypesNeuronsBrain
1992
Selective Role of N-Type Calcium Channels in Neuronal Migration
Komuro H, Rakic P. Selective Role of N-Type Calcium Channels in Neuronal Migration. Science 1992, 257: 806-809. PMID: 1323145, DOI: 10.1126/science.1323145.Peer-Reviewed Original ResearchConceptsN-type calcium channelsCalcium channelsNeuronal migrationT-type calcium channelsCerebellar slice preparationGranule cell migrationImmature neuronsSelective blockadeSlice preparationPostmitotic granule cellsAdult brainGranule cellsSynaptic circuitsNeurotransmitter releasePotassium channelsPlasmalemmal surfaceIncubation mediumCell migrationSelective roleLaser scanning confocal microscopeScanning confocal microscopeBlockadeSpecific developmental roleNeuronsBrain
1990
Developmental expression of GABA and subunits of the GABAA receptor complex in an inhibitory synaptic circuit in the rat cerebellum
Meinecke D, Rakic P. Developmental expression of GABA and subunits of the GABAA receptor complex in an inhibitory synaptic circuit in the rat cerebellum. Brain Research 1990, 55: 73-86. PMID: 2170058, DOI: 10.1016/0165-3806(90)90107-a.Peer-Reviewed Original ResearchConceptsGABAA receptor subunitsGranule cellsSynaptic circuitsGABAA receptorsPresynaptic elementsReceptor labelingReceptor subunitsGABAA/benzodiazepine receptor complexGolgi II neuronsInhibitory synaptic circuitsSpecific synaptic circuitsGranular layerInhibitory transmitter GABAFifth postnatal dayGABAA receptor complexCentral nervous systemCerebellum of ratsBenzodiazepine receptor complexMature granule cellsReceptor complexPresence of GABAInternal granular layerAlpha 1 subunitGABA transmittersGABAergic afferents
1989
GABAA/benzodiazepine receptor-like immunoreactivity in rat and monkey cerebellum
Meinecke D, Tallman J, Rakic P. GABAA/benzodiazepine receptor-like immunoreactivity in rat and monkey cerebellum. Brain Research 1989, 493: 303-319. PMID: 2548668, DOI: 10.1016/0006-8993(89)91165-7.Peer-Reviewed Original ResearchConceptsReceptor-like immunoreactivityGABAA/benzodiazepine receptorGolgi type II cellsType II cellsAxon terminalsBasket cellsBenzodiazepine receptorsCerebellar cortexCortical layersII cellsMonkey cerebellumUnlabeled axon terminalsCytoplasm of neuronsMossy fiber terminalsDeep cerebellar nucleiImmunoreactive dendritesSymmetric synapsesImmunostained neuronsInhibitory circuitsLabel neuronsGlial cellsNeuronal typesFiber terminalsGranule cellsStellate cellsMultiple types of neuropeptide Y‐containing neurons in primate neocortex
Kuljis R, Rakic P. Multiple types of neuropeptide Y‐containing neurons in primate neocortex. The Journal Of Comparative Neurology 1989, 280: 393-409. PMID: 2918101, DOI: 10.1002/cne.902800306.Peer-Reviewed Original ResearchConceptsAspiny stellate cellsStellate cellsNeuropeptide YSmall local circuit neuronsNPY-containing neuronsAvidin-biotin-peroxidase methodLocal circuit neuronsSpiny stellate cellsAdult macaque monkeysLocal neuronal circuitsCircuit neuronsLayer IVAElectron microscopic levelMartinotti cellsSupragranular layersLayer VIMultipolar neuronsLayer IVNonneuronal elementsCortical greyLaminar locationSpinous dendritesNeuronal typesPattern of ramificationGranule cells
1983
Differentiation of granule cell dendrites in the dentate gyrus of the rhesus monkey: A quantitative golgi study
Duffy C, Rakic P. Differentiation of granule cell dendrites in the dentate gyrus of the rhesus monkey: A quantitative golgi study. The Journal Of Comparative Neurology 1983, 214: 224-237. PMID: 6841685, DOI: 10.1002/cne.902140210.Peer-Reviewed Original ResearchConceptsGranule cell dendritesDentate gyrusCell dendritesDendritic spinesGranule cellsRhesus monkeysPostnatal rhesus monkeysQuantitative Golgi studyHippocampal granule cellsPostnatal day 3Time of birthRapid Golgi methodLength of dendritesDendritic lengthDendritic shaftsNeonatal levelsGolgi studyDistal thirdHippocampal regionDendritic branchingAdult monkeysDay 3Postnatal developmentGolgi methodLevel of maturation
1981
The time of origin of neurons in the hippocampal region of the rhesus monkey
Rakic P, Nowakowski R. The time of origin of neurons in the hippocampal region of the rhesus monkey. The Journal Of Comparative Neurology 1981, 196: 99-128. PMID: 7204668, DOI: 10.1002/cne.901960109.Peer-Reviewed Original ResearchConceptsHippocampal regionArea CA2Entorhinal areaArea CA1Fascia dentataGranule cellsRhesus monkeysFirst postnatal monthProduction of neuronsEmbryonic day 33Parasubicular neuronsHippocampal neurogenesisDentate gyrusArea CA4Stratum pyramidalePyramidal cellsPostnatal monthArea CA3Last neuronsHippocampal subdivisionsCell originParahippocampal formationHistological dataDay 33Neurons
1973
Organization of cerebellar cortex secondary to deficit of granule cells in weaver mutant mice
Rakic P, Sidman R. Organization of cerebellar cortex secondary to deficit of granule cells in weaver mutant mice. The Journal Of Comparative Neurology 1973, 152: 133-161. PMID: 4761656, DOI: 10.1002/cne.901520203.Peer-Reviewed Original ResearchConceptsGranule cellsExternal granular layerGolgi type II neuronsPurkinje cellsHeterozygous weaver miceType II neuronsMossy fiber terminalsWeaver mutant micePurkinje cell dendritesGranular layerExternal granule cellsIntrinsic axonsLocal cellular milieuSynaptic contactsForm synapsesEarly recognitionAxonal contactCell dendritesPostsynaptic elementsBergmann glial fibersMembrane thickeningMossy fibersDendritic spinesFiber terminalsMolecular layerSequence of developmental abnormalities leading to granule cell deficit in cerebellar cortex of weaver mutant mice
Rakic P, Sidman R. Sequence of developmental abnormalities leading to granule cell deficit in cerebellar cortex of weaver mutant mice. The Journal Of Comparative Neurology 1973, 152: 103-132. PMID: 4128371, DOI: 10.1002/cne.901520202.Peer-Reviewed Original Research