2024
Lateral expansion of the mammalian cerebral cortex is related to anchorage of centrosomes in apical neural progenitors
Morozov Y, Rakic P. Lateral expansion of the mammalian cerebral cortex is related to anchorage of centrosomes in apical neural progenitors. Cerebral Cortex 2024, 34: bhae293. PMID: 39024157, DOI: 10.1093/cercor/bhae293.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsProgenitor cellsVentricular zoneCerebral cortexBasolateral cell membraneApical anchorageProlonged neurogenesisMammalian cerebral cortexPrimary ciliaApical neural progenitorsCell membraneFraction of cellsNeural progenitorsStem cellsCerebral neurogenesisApical segmentsDevelopment of ciliaNuclear translocationMicrotubule organizing centerNeurogenesisCellsMacaque monkeysSpecies-specific differencesCortexBasal bodies
2022
Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex
Rash B, Arellano J, Duque A, Rakic P. Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 120: e2210967120. PMID: 36574666, PMCID: PMC9910595, DOI: 10.1073/pnas.2210967120.Peer-Reviewed Original ResearchConceptsOuter subventricular zoneSubcortical white matterCerebral cortexWhite matterFormation of gyriPrimate cerebral cortexMammalian cerebral cortexMarkers of proliferationCortical malformationsCortical plateGlial cellsGyral developmentSubventricular zoneCortical neurogenesisFetal developmentVentricular zoneCortical foldingNeuronal progenitorsGyrificationNeuronal growthNeuropil growthPrimary gyriCortexNeurodevelopmental disordersGyrus
2019
Introduction
Singer W, Sejnowski T, Rakic P. Introduction. 2019, 13-20. DOI: 10.7551/mitpress/12593.003.0003.Peer-Reviewed Original ResearchEvolution and Ontogenetic Development of Cortical Structures
Silver D, Rakic P, Grove E, Haydar T, Hensch T, Huttner W, Molnár Z, Rubenstein J, Sestan N, Stryker M, Sur M, Tosches M, Walsh C. Evolution and Ontogenetic Development of Cortical Structures. 2019, 73-106. DOI: 10.7551/mitpress/12593.003.0008.Peer-Reviewed Original Research
2009
Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling
Torii M, Hashimoto-Torii K, Levitt P, Rakic P. Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling. Nature 2009, 461: 524-528. PMID: 19759535, PMCID: PMC2874978, DOI: 10.1038/nature08362.Peer-Reviewed Original ResearchConceptsNeocortical excitatory neuronsRadial glial fibersColumnar organizationEphA/ephrinCerebral cortexFunctional impairmentNeuronal clonesExcitatory neuronsGlial fibersTangential migrationCortical columnsNeural progenitorsCircuit developmentEphrinProliferative unitsPopulationClonal populationsCortexNeurons
2007
4.14 The Development and Evolutionary Expansion of the Cerebral Cortex in Primates
Rakic P, Kornack D. 4.14 The Development and Evolutionary Expansion of the Cerebral Cortex in Primates. 2007, 243-259. DOI: 10.1016/b0-12-370878-8/00004-5.Peer-Reviewed Original ResearchEvolutionary expansionSpecies-specific sizeSmall genetic differencesCerebral cortexEvolutionary mechanismsMammalian speciesBrain evolutionCell cycleCellular eventsSpontaneous mutationsGenetic differencesRadial unit hypothesisRodent embryosBasic organizationModern neurobiologyEmbryosNew insightsNon-human primatesCorticogenesisHuman uniquenessBiological substratesCortexNeuronal interactionsEmbryogenesisHuman cerebrum
2002
Pre- and post-developmental neurogenesis in primates
Rakic P. Pre- and post-developmental neurogenesis in primates. Clinical Neuroscience Research 2002, 2: 29-39. DOI: 10.1016/s1566-2772(02)00005-1.Peer-Reviewed Original ResearchPrimate brainMonkey central nervous systemAdult primate brainClasses of neuronsCentral nervous systemForm of therapyCerebral cortexMost neuronsDentate gyrusCompetent neuronsOlfactory bulbNervous systemBromodeoxyuridine methodNeuronal classesDevelopmental periodSpecific developmental periodsNeuronsCell classesNeurogenesisBrainLower ratesEntire life spanLife spanRegional differencesTherapy
2001
Development of Layer I Neurons in the Primate Cerebral Cortex
Zecevic N, Rakic P. Development of Layer I Neurons in the Primate Cerebral Cortex. Journal Of Neuroscience 2001, 21: 5607-5619. PMID: 11466432, PMCID: PMC6762645, DOI: 10.1523/jneurosci.21-15-05607.2001.Peer-Reviewed Original ResearchConceptsCerebral cortexLayer ILayer I cellsLayer I neuronsPrimate cerebral cortexCajal-Retzius cellsSubpial granular layerGABAergic neuronsGABAergic interneuronsCortical plateI neuronsGanglionic eminenceMacaque monkeysPial surfaceOlfactory primordiumI cellsNeuronsMonth periodLong gestationGranular layerCortexUltrastructural analysisCorticogenesisCellsPrimates
2000
Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain
Laywell E, Rakic P, Kukekov V, Holland E, Steindler D. Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 13883-13888. PMID: 11095732, PMCID: PMC17670, DOI: 10.1073/pnas.250471697.Peer-Reviewed Original ResearchConceptsCentral nervous systemNeural stem cellsAstrocyte monolayersMultipotent astrocytic stem cellsAstrocytic stem cellsPostnatal central nervous systemAdult mouse brainStem cellsCerebral cortexPostnatal wkSpinal cordAdult brainSubependymal zoneNervous systemEpendymal cellsMouse brainMammalian brainSpherical clonesCNS developmentBrainVivo identificationAstrocytesMature forebrainCritical periodCE cellsRadial Unit Hypothesis of Neocortical Expansion
Rakic P. Radial Unit Hypothesis of Neocortical Expansion. Novartis Foundation Symposia 2000, 228: 30-45. PMID: 10929315, DOI: 10.1002/0470846631.ch3.Peer-Reviewed Original ResearchConceptsRadial unit hypothesisSpecies-specific sizeFamily of genesMutations of genesVentricular zoneMammalian evolutionFounder cellsNatural selectionRegulatory genesCell divisionMorphoregulatory moleculesPostmitotic cellsTransgenic animalsCortical plateCell deathNeocortical expansionGenesBasic organizationGlial scaffoldingColumnar unitsCortical cellsCerebral cortexCellsCortical developmentSynaptic connections
1999
Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling
Šestan N, Artavanis-Tsakonas S, Rakic P. Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling. Science 1999, 286: 741-746. PMID: 10531053, DOI: 10.1126/science.286.5440.741.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CommunicationCell CountCell DifferentiationCell MovementCell NucleusCell SizeCells, CulturedCerebral CortexContact InhibitionHumansLigandsMembrane ProteinsMiceMitosisNeuritesNeuronsProtein Structure, TertiaryReceptor, Notch1Receptor, Notch2Receptors, Cell SurfaceSignal TransductionTranscription FactorsTranscriptional ActivationUp-RegulationConceptsNeurite growthMouse cerebral cortexCapacity of neuronsCortical neurite growthStudy of neuronsInhibition of NotchCerebral cortexNotch signalingCortical neuronsNotch activityMature neuronsInterneuronal contactsRetraction of neuritesHigh Notch activityNeuronsNeuronal growthNeuritesContact-dependent inhibitionExuberant growthNeurite extensionNotch receptorsInhibitionLow Notch activitySignalingActivityMolecular Gradients and Compartments in the Embryonic Primate Cerebral Cortex
Donoghue M, Rakic P. Molecular Gradients and Compartments in the Embryonic Primate Cerebral Cortex. Cerebral Cortex 1999, 9: 586-600. PMID: 10498277, DOI: 10.1093/cercor/9.6.586.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntisense Elements (Genetics)Brain ChemistryCloning, MolecularDNA-Binding ProteinsEphrin-A1FemaleGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicHomeodomain ProteinsIn Situ HybridizationMacaca mulattaNeocortexNeuronsPregnancyProsencephalonProteinsReceptor Protein-Tyrosine KinasesTranscription FactorsConceptsCerebral cortexPrimate cerebral cortexEmbryonic cerebral cortexMature cerebral cortexEphA receptor tyrosine kinasesArrival of afferentsPrimate forebrainCortical plateMature cortexEfferent connectionsCortical developmentCortical areasAnteroposterior extentSpecific afferentsMacaque monkeysReceptor tyrosine kinasesPeripheral influencesCortexGene expressionPrimate corticogenesisAfferentsNeocortexIntrinsic programCorticogenesisTyrosine kinaseMolecular Evidence for the Early Specification of Presumptive Functional Domains in the Embryonic Primate Cerebral Cortex
Donoghue M, Rakic P. Molecular Evidence for the Early Specification of Presumptive Functional Domains in the Embryonic Primate Cerebral Cortex. Journal Of Neuroscience 1999, 19: 5967-5979. PMID: 10407035, PMCID: PMC6783094, DOI: 10.1523/jneurosci.19-14-05967.1999.Peer-Reviewed Original ResearchConceptsCortical platePresumptive visual cortexPrimate cerebral cortexLigand ephrin-A5Appropriate synaptic connectionsCortical cellsThalamocortical connectionsCerebral cortexMonkey neocortexCortical developmentPrimate neocortexVisual cortexSynaptic connectionsEphrin-A3Ephrin-A2Extrastriate cortexEarly gene expressionEmbryonic neocortexEphrin-A5Molecular patternsNeocortexCortexEphA6Primate corticogenesisPosterior regionDistinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex
Anton E, Kreidberg J, Rakic P. Distinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex. Neuron 1999, 22: 277-289. PMID: 10069334, DOI: 10.1016/s0896-6273(00)81089-2.Peer-Reviewed Original ResearchConceptsCerebral cortexNeuronal migrationNeuron-glial interactionsΑv integrin receptorsRadial glial cellsRadial glial fibersCortical neuronsGlial cellsAbnormal layeringLaminar organizationGlial fibersCortexNeuronsSpecific cell-cell recognitionAlpha3beta1 integrinIntegrin receptorsIntegrin geneIntegrinsTargeted mutationsIntegrin functionCorticogenesisReceptors
1997
Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex.
Anton E, Marchionni M, Lee K, Rakic P. Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex. Development 1997, 124: 3501-10. PMID: 9342043, DOI: 10.1242/dev.124.18.3501.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCell CommunicationCell MovementCerebral CortexCulture TechniquesFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsGlycoproteinsNerve Growth FactorsNerve Tissue ProteinsNeuregulinsNeurogliaNeuronsRatsRats, Sprague-DawleyReceptor, ErbB-2Receptors, Nerve Growth FactorSignal TransductionConceptsRadial glial developmentRadial glial cellsBrain lipid-binding proteinCerebral cortexGlial cellsNeuronal migrationGlial developmentRadial glial cell functionGlial growth factorGlial cell functionRadial glial fibersRadial glial fiber systemNeuronal cell migrationCortical neuronsGlial interactionsRadial gliaGlial fibersGlial moleculesCortexNeuronsGrowth factorErbB2 receptorCell functionDependent mannerCell migrationRestrictive clonal allocation in the chimeric mouse brain
Kuan C, Elliott E, Flavell R, Rakic P. Restrictive clonal allocation in the chimeric mouse brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 3374-3379. PMID: 9096401, PMCID: PMC20377, DOI: 10.1073/pnas.94.7.3374.Peer-Reviewed Original ResearchConceptsBrain regionsChimeric mouse brainsMammalian cerebral cortexDifferent brain regionsCerebral cortexCerebral neocortexChimeric miceMouse brainChimeric brainsMammalian brainProgenitor cellsBrainClones of cellsNeocortexStem cellsBlastocyst embryosCellsDifferent subsetsVast majorityCell descendantsPrevious studiesCortexMice
1996
Selective expression of m2 muscarinic receptor in the parvocellular channel of the primate visual cortex.
Mrzljak L, Levey A, Rakic P. Selective expression of m2 muscarinic receptor in the parvocellular channel of the primate visual cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 7337-7340. PMID: 8692994, PMCID: PMC38985, DOI: 10.1073/pnas.93.14.7337.Peer-Reviewed Original ResearchConceptsDorsal lateral geniculate nucleusLateral geniculate nucleusGeniculate nucleusVisual cortexMacaque monkey visual cortexM2 muscarinic acetylcholine receptorM2 muscarinic receptorsM2 receptor proteinMuscarinic acetylcholine receptorsMonkey visual cortexPrimate visual cortexM2 receptorsCerebral cortexMuscarinic receptorsExcitatory neurotransmissionParvocellular layersLayers IIAcetylcholine receptorsSynaptic circuitsNeuronal channelsParvocellular channelsParvocellular pathwayCortexSelective expressionReceptorsRole of neuron-glial junctional domain proteins in the maintenance and termination of neuronal migration across the embryonic cerebral wall
Anton E, Cameron R, Rakic P. Role of neuron-glial junctional domain proteins in the maintenance and termination of neuronal migration across the embryonic cerebral wall. Journal Of Neuroscience 1996, 16: 2283-2293. PMID: 8601808, PMCID: PMC6578523, DOI: 10.1523/jneurosci.16-07-02283.1996.Peer-Reviewed Original ResearchConceptsEmbryonic cerebral wallCerebral wallNeuronal migrationCerebral cortexNeuronal migratory pathwayRadial glial cell processesRadial glial fibersGlial cell processesNormal neuronal migrationCortical plateSlice preparationAntibody exposureGlial fibersMarginal zone regionsMonoclonal antibodiesAntibodiesNeuronsCortexCell substratesMarginal zonePolyclonal antiserumMicrotubular organizationCell processesMigratory pathwaysCell detachment
1995
Distribution and density of monoamine receptors in the primate visual cortex devoid of retinal input from early embryonic stages
Rakic P, Lidow. Distribution and density of monoamine receptors in the primate visual cortex devoid of retinal input from early embryonic stages. Journal Of Neuroscience 1995, 15: 2561-2574. PMID: 7891189, PMCID: PMC6578103, DOI: 10.1523/jneurosci.15-03-02561.1995.Peer-Reviewed Original ResearchConceptsMonoamine receptorsVisual cortexLaminar distributionSpecific laminar patternMonths of agePrimate visual cortexGroups of animalsBinocular enucleationCortical consequencesPrestriate areasCerebral cortexMonoaminergic receptorsSupragranular layersCortical plateLayer IVCongenital anophthalmiaGeniculocortical fibersOccipital lobeCortical bindingLaminar patternRetinal inputNeurotransmitter receptorsMonkey striateCoronal planeDistinct laminar
1994
Synaptogenesis in the Prefrontal Cortex of Rhesus Monkeys
Bourgeois J, Goldman-Rakic P, Rakic P. Synaptogenesis in the Prefrontal Cortex of Rhesus Monkeys. Cerebral Cortex 1994, 4: 78-96. PMID: 8180493, DOI: 10.1093/cercor/4.1.78.Peer-Reviewed Original ResearchConceptsYears of ageSynaptic densityPrefrontal cortexCortical plateMotor areaRhesus monkeysDensity of synapsesQuantitative electron microscopic analysisCourse of synaptogenesisHigh synaptic densityWhole cortical thicknessPrefrontal association areasMacaque prefrontal cortexCerebral cortexDendritic shaftsSupragranular layersCortical circuitryCortical thicknessCortical mantleAssociation areasSynapse formationDay 47Selective increaseCortexSynapses