2023
Old Models Know Wrinkles Best
Arellano J, Rakic P. Old Models Know Wrinkles Best. 2023, 499-525. DOI: 10.1002/9781119860914.ch23.Peer-Reviewed Original Research
2009
Selective reduction of neuron number and volume of the mediodorsal nucleus of the thalamus in macaques following irradiation at early gestational ages
Selemon LD, Begović A, Rakic P. Selective reduction of neuron number and volume of the mediodorsal nucleus of the thalamus in macaques following irradiation at early gestational ages. The Journal Of Comparative Neurology 2009, 515: 454-464. PMID: 19459221, PMCID: PMC2716797, DOI: 10.1002/cne.22078.Peer-Reviewed Original Research
2002
Pre- and post-developmental neurogenesis in primates
Rakic P. Pre- and post-developmental neurogenesis in primates. Clinical Neuroscience Research 2002, 2: 29-39. DOI: 10.1016/s1566-2772(02)00005-1.Peer-Reviewed Original ResearchPrimate brainMonkey central nervous systemAdult primate brainClasses of neuronsCentral nervous systemForm of therapyCerebral cortexMost neuronsDentate gyrusCompetent neuronsOlfactory bulbNervous systemBromodeoxyuridine methodNeuronal classesDevelopmental periodSpecific developmental periodsNeuronsCell classesNeurogenesisBrainLower ratesEntire life spanLife spanRegional differencesTherapy
2001
The generation, migration, and differentiation of olfactory neurons in the adult primate brain
Kornack D, Rakic P. The generation, migration, and differentiation of olfactory neurons in the adult primate brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 4752-4757. PMID: 11296302, PMCID: PMC31906, DOI: 10.1073/pnas.081074998.Peer-Reviewed Original ResearchConceptsRostral migratory streamOlfactory bulbAdult primate brainAdult macaque monkeysNeural progenitor cellsSmaller olfactory bulbsAdult rodentsSubependymal zoneImmunohistochemical detectionPrimate brainMacaque monkeysOlfactory neuronsMigratory streamNonhuman primatesProgenitor cellsRegenerative mechanismsInterneuronsHuman brainBrainNeuroblastsCellsNeurons
2000
Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain
Laywell E, Rakic P, Kukekov V, Holland E, Steindler D. Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 13883-13888. PMID: 11095732, PMCID: PMC17670, DOI: 10.1073/pnas.250471697.Peer-Reviewed Original ResearchConceptsCentral nervous systemNeural stem cellsAstrocyte monolayersMultipotent astrocytic stem cellsAstrocytic stem cellsPostnatal central nervous systemAdult mouse brainStem cellsCerebral cortexPostnatal wkSpinal cordAdult brainSubependymal zoneNervous systemEpendymal cellsMouse brainMammalian brainSpherical clonesCNS developmentBrainVivo identificationAstrocytesMature forebrainCritical periodCE cells
1999
Discriminating migrations
Rakic P. Discriminating migrations. Nature 1999, 400: 315-316. PMID: 10432106, DOI: 10.1038/22427.Peer-Reviewed Original Research
1998
Young neurons for old brains?
Rakic P. Young neurons for old brains? Nature Neuroscience 1998, 1: 645-647. PMID: 10196576, DOI: 10.1038/3643.Peer-Reviewed Original Research
1997
Restrictive clonal allocation in the chimeric mouse brain
Kuan C, Elliott E, Flavell R, Rakic P. Restrictive clonal allocation in the chimeric mouse brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 3374-3379. PMID: 9096401, PMCID: PMC20377, DOI: 10.1073/pnas.94.7.3374.Peer-Reviewed Original ResearchConceptsBrain regionsChimeric mouse brainsMammalian cerebral cortexDifferent brain regionsCerebral cortexCerebral neocortexChimeric miceMouse brainChimeric brainsMammalian brainProgenitor cellsBrainClones of cellsNeocortexStem cellsBlastocyst embryosCellsDifferent subsetsVast majorityCell descendantsPrevious studiesCortexMice
1993
Modulation of Neuronal Migration by NMDA Receptors
Komuro H, Rakic P. Modulation of Neuronal Migration by NMDA Receptors. Science 1993, 260: 95-97. PMID: 8096653, DOI: 10.1126/science.8096653.Peer-Reviewed Original ResearchConceptsNMDA receptorsN-methyl-D-aspartate (NMDA) subtypeEndogenous extracellular glutamateCell migrationNMDA receptor activityElimination of synapsesApplication of glycineSynaptic contactsSlice preparationExtracellular glutamateGlutamate receptorsSpecific antagonistGranule cellsReceptor activityNeuronal migrationNeuronal differentiationReceptorsMouse cerebellumEarly roleBlockadeAntagonistCerebellumSubtypesNeuronsBrain
1992
Selective Role of N-Type Calcium Channels in Neuronal Migration
Komuro H, Rakic P. Selective Role of N-Type Calcium Channels in Neuronal Migration. Science 1992, 257: 806-809. PMID: 1323145, DOI: 10.1126/science.1323145.Peer-Reviewed Original ResearchConceptsN-type calcium channelsCalcium channelsNeuronal migrationT-type calcium channelsCerebellar slice preparationGranule cell migrationImmature neuronsSelective blockadeSlice preparationPostmitotic granule cellsAdult brainGranule cellsSynaptic circuitsNeurotransmitter releasePotassium channelsPlasmalemmal surfaceIncubation mediumCell migrationSelective roleLaser scanning confocal microscopeScanning confocal microscopeBlockadeSpecific developmental roleNeuronsBrain
1990
Principles of neural cell migration
Rakic P. Principles of neural cell migration. Cellular And Molecular Life Sciences 1990, 46: 882-891. PMID: 2209797, DOI: 10.1007/bf01939380.Peer-Reviewed Original ResearchConceptsNervous systemMammalian central nervous systemClasses of neuronsCentral nervous systemNeural cell migrationAdult nervous systemCell migrationNeuronal cell migrationImmature neuronsBrain abnormalitiesSynaptic connectivityFinal mitotic divisionMolecular cuesNeuronsDistant structuresProliferative centersNeuron positionCell-cell interactionsCell morphologyCongenitalAbnormalitiesBrain
1988
Defects of neuronal migration and the pathogenesis of cortical malformations
Rakic P, Swaab D. Defects of neuronal migration and the pathogenesis of cortical malformations. Progress In Brain Research 1988, 73: 15-37. PMID: 3047794, DOI: 10.1016/s0079-6123(08)60494-x.Peer-Reviewed Original Research
1986
Mechanism of ocular dominance segregation in the lateral geniculate nucleus: competitive elimination hypothesis
Rakic P. Mechanism of ocular dominance segregation in the lateral geniculate nucleus: competitive elimination hypothesis. Trends In Neurosciences 1986, 9: 11-15. DOI: 10.1016/0166-2236(86)90005-6.Peer-Reviewed Original Research
1985
Limits of Neurogenesis in Primates
Rakic P. Limits of Neurogenesis in Primates. Science 1985, 227: 1054-1056. PMID: 3975601, DOI: 10.1126/science.3975601.Peer-Reviewed Original Research
1984
Emergence of Neuronal and Glial Cell Lineages in Primate Brain
Rakic P. Emergence of Neuronal and Glial Cell Lineages in Primate Brain. 1984, 29-50. DOI: 10.1007/978-1-4613-2717-2_2.Peer-Reviewed Original ResearchMammalian brainGlial cellsGlial cell lineagesCell lineagesNeural tubeGlial lineagesNeuronal cellsCellular mechanismsMajority of cellsNeuronal-glial interactionsCell linesLineagesPrimitive neural tubeCellsYoung neuronsFunctional abnormalitiesPrimate brainImportant roleBrainCompartmentalizationNeuronsDivergenceRegulationNeuroepitheliumNeuronal
1982
Ontogeny State of the Art Report
Strichartz G, Aguayo A, Cowan W, Distel H, Lim L, McKhann G, Mugnaini E, Rakic P, Rickmann M, Spitzer N, Webster H. Ontogeny State of the Art Report. Dahlem Workshop Report 1982, 93-114. DOI: 10.1007/978-3-642-68466-1_9.Peer-Reviewed Original Research
1981
Development of Visual Centers in the Primate Brain Depends on Binocular Competition Before Birth
Rakic P. Development of Visual Centers in the Primate Brain Depends on Binocular Competition Before Birth. Science 1981, 214: 928-931. PMID: 7302569, DOI: 10.1126/science.7302569.Peer-Reviewed Original ResearchConceptsVisual centersPrimate brainAberrant synaptic connectionsLateral geniculate nucleusOcular dominance columnsGeniculate neuronsGeniculate nucleusSynaptic connectivityIntact eyeVisual cortexSynaptic connectionsBinocular competitionCellular layersBrainBirthNotable alterationsEyesNormal inputFiber bandsCortexNeuronsNeuronal-glial interaction during brain development
Rakic P. Neuronal-glial interaction during brain development. Trends In Neurosciences 1981, 4: 184-187. DOI: 10.1016/0166-2236(81)90060-6.Peer-Reviewed Original ResearchRadial glial cellsGlial cellsNeuronal-glial interactionsGlial cell classesPositioning of neuronsPeak of neurogenesisRecent immunocytochemical studiesImmature neuronsCerebellar cortexPrimate brainImmunocytochemical studyBrain developmentCell precursorsCell classesSpecific markersNeuronsNeuron tissueElectron microscopic analysisCellsNeurogenesisCortexBrain
1968
Subcommissural organ and adjacent ependyma: Autoradiographic study of their origin in the mouse brain
Rakic P, Sidman R. Subcommissural organ and adjacent ependyma: Autoradiographic study of their origin in the mouse brain. Developmental Dynamics 1968, 122: 317-335. PMID: 5659133, DOI: 10.1002/aja.1001220210.Peer-Reviewed Original Research