Unfolded Protein Response Regulation in Keloid Cells
Butler PD, Wang Z, Ly DP, Longaker MT, Koong AC, Yang GP. Unfolded Protein Response Regulation in Keloid Cells. Journal Of Surgical Research 2009, 167: 151-157. PMID: 19631342, PMCID: PMC2888625, DOI: 10.1016/j.jss.2009.04.036.Peer-Reviewed Original ResearchConceptsUnfolded protein responsePancreatic ER kinaseXBP-1 proteinNuclear localizationXBP-1Keloid fibroblastsNormal fibroblastsExtracellular matrixXBP-1 splicingUPR transducersSpecific molecular defectsPathologic wound healingUPR responseUPR activationProtein responseER kinaseCellular responsesMolecular defectsATF-6Keloid cellsResponse regulationProteinWound healing therapyWound microenvironmentActivation